Cargando…
Medical Resource Use and Medical Costs for Radiotherapy-Related Adverse Effects: A Systematic Review
SIMPLE SUMMARY: Cancer patients who receive radiotherapy often suffer from adverse effects that require healthcare resources to manage. This study summarized evidence of healthcare resource use and costs related to radiotherapy-induced adverse effects and provided recommendations for including this...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139402/ https://www.ncbi.nlm.nih.gov/pubmed/35626049 http://dx.doi.org/10.3390/cancers14102444 |
_version_ | 1784714851497541632 |
---|---|
author | Chen, Yi Hsuan Molenaar, Dominique Uyl-de Groot, Carin A. van Vulpen, Marco Blommestein, Hedwig M. |
author_facet | Chen, Yi Hsuan Molenaar, Dominique Uyl-de Groot, Carin A. van Vulpen, Marco Blommestein, Hedwig M. |
author_sort | Chen, Yi Hsuan |
collection | PubMed |
description | SIMPLE SUMMARY: Cancer patients who receive radiotherapy often suffer from adverse effects that require healthcare resources to manage. This study summarized evidence of healthcare resource use and costs related to radiotherapy-induced adverse effects and provided recommendations for including this evidence in economic evaluations. Our findings revealed unignorable differences for the same adverse effects, which implied that the potential for the economic burden of adverse effects was overestimated or underestimated. ABSTRACT: Background: Despite the need for a proper economic evaluation of new radiotherapies, the economic burden of radiotherapy-induced adverse effects remains unclear. A systematic review has been conducted to identify the existing evidence of healthcare resource use and costs related to radiotherapy-induced adverse effects and also to provide recommendations for including this evidence in economic evaluations. Methods: This systematic review of healthcare resource use and/or medical costs related to radiotherapy-induced adverse effects was performed up until 2020, focusing on patients with head and neck cancer, brain cancer, prostate cancer, eye cancer and breast cancer. Results: Resource use for treating the same adverse effects varied considerably across studies; for instance, the cost for mucositis ranged from USD 2949 to USD 17,244. This broad range could be related to differences in (1) severity of adverse effects in the study population, (2) study design, (3) cost estimation approach and (4) country and clinical practice. Conclusions: Our findings revealed unignorable differences for the same adverse effects, which implied that the potential for the economic burden of adverse effects was being overestimated or underestimated in economic evaluation for radiotherapy. |
format | Online Article Text |
id | pubmed-9139402 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91394022022-05-28 Medical Resource Use and Medical Costs for Radiotherapy-Related Adverse Effects: A Systematic Review Chen, Yi Hsuan Molenaar, Dominique Uyl-de Groot, Carin A. van Vulpen, Marco Blommestein, Hedwig M. Cancers (Basel) Systematic Review SIMPLE SUMMARY: Cancer patients who receive radiotherapy often suffer from adverse effects that require healthcare resources to manage. This study summarized evidence of healthcare resource use and costs related to radiotherapy-induced adverse effects and provided recommendations for including this evidence in economic evaluations. Our findings revealed unignorable differences for the same adverse effects, which implied that the potential for the economic burden of adverse effects was overestimated or underestimated. ABSTRACT: Background: Despite the need for a proper economic evaluation of new radiotherapies, the economic burden of radiotherapy-induced adverse effects remains unclear. A systematic review has been conducted to identify the existing evidence of healthcare resource use and costs related to radiotherapy-induced adverse effects and also to provide recommendations for including this evidence in economic evaluations. Methods: This systematic review of healthcare resource use and/or medical costs related to radiotherapy-induced adverse effects was performed up until 2020, focusing on patients with head and neck cancer, brain cancer, prostate cancer, eye cancer and breast cancer. Results: Resource use for treating the same adverse effects varied considerably across studies; for instance, the cost for mucositis ranged from USD 2949 to USD 17,244. This broad range could be related to differences in (1) severity of adverse effects in the study population, (2) study design, (3) cost estimation approach and (4) country and clinical practice. Conclusions: Our findings revealed unignorable differences for the same adverse effects, which implied that the potential for the economic burden of adverse effects was being overestimated or underestimated in economic evaluation for radiotherapy. MDPI 2022-05-16 /pmc/articles/PMC9139402/ /pubmed/35626049 http://dx.doi.org/10.3390/cancers14102444 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Systematic Review Chen, Yi Hsuan Molenaar, Dominique Uyl-de Groot, Carin A. van Vulpen, Marco Blommestein, Hedwig M. Medical Resource Use and Medical Costs for Radiotherapy-Related Adverse Effects: A Systematic Review |
title | Medical Resource Use and Medical Costs for Radiotherapy-Related Adverse Effects: A Systematic Review |
title_full | Medical Resource Use and Medical Costs for Radiotherapy-Related Adverse Effects: A Systematic Review |
title_fullStr | Medical Resource Use and Medical Costs for Radiotherapy-Related Adverse Effects: A Systematic Review |
title_full_unstemmed | Medical Resource Use and Medical Costs for Radiotherapy-Related Adverse Effects: A Systematic Review |
title_short | Medical Resource Use and Medical Costs for Radiotherapy-Related Adverse Effects: A Systematic Review |
title_sort | medical resource use and medical costs for radiotherapy-related adverse effects: a systematic review |
topic | Systematic Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139402/ https://www.ncbi.nlm.nih.gov/pubmed/35626049 http://dx.doi.org/10.3390/cancers14102444 |
work_keys_str_mv | AT chenyihsuan medicalresourceuseandmedicalcostsforradiotherapyrelatedadverseeffectsasystematicreview AT molenaardominique medicalresourceuseandmedicalcostsforradiotherapyrelatedadverseeffectsasystematicreview AT uyldegrootcarina medicalresourceuseandmedicalcostsforradiotherapyrelatedadverseeffectsasystematicreview AT vanvulpenmarco medicalresourceuseandmedicalcostsforradiotherapyrelatedadverseeffectsasystematicreview AT blommesteinhedwigm medicalresourceuseandmedicalcostsforradiotherapyrelatedadverseeffectsasystematicreview |