Cargando…

Disentangling ERBB Signaling in Breast Cancer Subtypes—A Model-Based Analysis

SIMPLE SUMMARY: Breast cancer subtypes are characterized by the expression and activity of estrogen-, progesterone- and HER2-receptors and differ by the treatment as well as patient prognosis. Tumors of the HER2-subtype overexpress this receptor and are successfully targeted with anti-HER2 therapies...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kemmer, Svenja, Berdiel-Acer, Mireia, Reinz, Eileen, Sonntag, Johanna, Tarade, Nooraldeen, Bernhardt, Stephan, Fehling-Kaschek, Mirjam, Hasmann, Max, Korf, Ulrike, Wiemann, Stefan, Timmer, Jens
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139462/ https://www.ncbi.nlm.nih.gov/pubmed/35625984 http://dx.doi.org/10.3390/cancers14102379

Ejemplares similares

Strong EGFR signaling in cell line models of ERBB2-amplified breast cancer attenuates response towards ERBB2-targeting drugs
por: Henjes, F, et al.
Publicado: (2012)

IFNβ1 secreted by breast cancer cells undergoing chemotherapy reprograms stromal fibroblasts to support tumour growth after treatment
por: Maia, Ana, et al.
Publicado: (2021)

Metabolic transformations in breast cancer subtypes
por: Mitra, Devina, et al.
Publicado: (2014)

Stromal NRG1 in luminal breast cancer defines pro-fibrotic and migratory cancer-associated fibroblasts
por: Berdiel-Acer, Mireia, et al.
Publicado: (2021)

BlotIt—Optimal alignment of Western blot and qPCR experiments
por: Kemmer, Svenja, et al.
Publicado: (2022)

Boolean ErbB network reconstructions and perturbation simulations reveal individual drug response in different breast cancer cell lines
por: der Heyde, Silvia Von, et al.
Publicado: (2014)

Mathematical modeling of drug-induced receptor internalization in the HER2-positive SKBR3 breast cancer cell-line
por: Fehling-Kaschek, Mirjam, et al.
Publicado: (2019)

Modeling ERBB receptor-regulated G1/S transition to find novel targets for de novo trastuzumab resistance
por: Sahin, Özgür, et al.
Publicado: (2009)

TGFβ1 regulates HGF‐induced cell migration and hepatocyte growth factor receptor MET expression via C‐ets‐1 and miR‐128‐3p in basal‐like breast cancer
por: Breunig, Christian, et al.
Publicado: (2018)

Profiling metabolic changes in breast cancer with targeted proteomics
por: Bernhardt, Stephan, et al.
Publicado: (2014)

Search for Scalar Bottom and Top Quarks with the ATLAS Detector at the LHC
por: Fehling-Kaschek, Mirjam
Publicado: (2015)

Plant-type phytoene desaturase: Functional evaluation of structural implications
por: Koschmieder, Julian, et al.
Publicado: (2017)

Pertuzumab Increases 17-AAG-Induced Degradation of ErbB2, and This Effect Is Further Increased by Combining Pertuzumab with Trastuzumab
por: Hughes, Juliana Bentes, et al.
Publicado: (2012)

Biohybrid Circuits: Biofunctionalized Materials Featuring Feedforward and Feedback Circuits Exemplified by the Detection of Botulinum Toxin A (Adv. Sci. 4/2019)
por: Wagner, Hanna J., et al.
Publicado: (2019)

Biofunctionalized Materials Featuring Feedforward and Feedback Circuits Exemplified by the Detection of Botulinum Toxin A
por: Wagner, Hanna J., et al.
Publicado: (2018)

Automated production of recombinant human proteins as resource for proteome research
por: Kohl, Thorsten, et al.
Publicado: (2008)

Liquid-phase electron microscopy of molecular drug response in breast cancer cells reveals irresponsive cell subpopulations related to lack of HER2 homodimers
por: Peckys, Diana B., et al.
Publicado: (2017)

Enzymatic study on AtCCD4 and AtCCD7 and their potential to form acyclic regulatory metabolites
por: Bruno, Mark, et al.
Publicado: (2016)

Dynamic deterministic effects propagation networks: learning signalling pathways from longitudinal protein array data
por: Bender, Christian, et al.
Publicado: (2010)

Analysis of Reverse Phase Protein Array Data: From Experimental Design towards Targeted Biomarker Discovery
por: Wachter, Astrid, et al.
Publicado: (2015)

Inferring signalling networks from longitudinal data using sampling based approaches in the R-package 'ddepn'
por: Bender, Christian, et al.
Publicado: (2011)

RNAi-based validation of antibodies for reverse phase protein arrays
por: Mannsperger, Heiko A, et al.
Publicado: (2010)

A 5-gene classifier from the carcinoma-associated fibroblast transcriptomic profile and clinical outcome in colorectal cancer
por: Berdiel-Acer, Mireia, et al.
Publicado: (2014)

Carcinoma-associated fibroblasts affect sensitivity to oxaliplatin and 5FU in colorectal cancer cells
por: Gonçalves-Ribeiro, Samuel, et al.
Publicado: (2016)

Disentangling the Complexity of HGF Signaling by Combining Qualitative and Quantitative Modeling
por: D’Alessandro, Lorenza A., et al.
Publicado: (2015)

Dissecting the midlife crisis: disentangling social, personality and demographic determinants in social brain anatomy
por: Kiesow, Hannah, et al.
Publicado: (2021)

Combinatorial targeting of FGF and ErbB receptors blocks growth and metastatic spread of breast cancer models
por: Issa, Amine, et al.
Publicado: (2013)

Disentangling the mechanisms shaping the surface ocean microbiota
por: Logares, Ramiro, et al.
Publicado: (2020)

A variational approach to parameter estimation in ordinary differential equations
por: Kaschek, Daniel, et al.
Publicado: (2012)

Disentangling the Benefits of Sex
por: Roze, Denis
Publicado: (2012)

Disentangling malaria anaemia
por: Schuldt, Kathrin, et al.
Publicado: (2014)

Disentangling molecular mechanisms regulating sensitization of interferon alpha signal transduction
por: Kok, Frédérique, et al.
Publicado: (2020)

Quantitative Phosphoproteomics Analysis of ERBB3/ERBB4 Signaling
por: Wandinger, Sebastian K., et al.
Publicado: (2016)

Dynamic modeling of Nrf2 pathway activation in liver cells after toxicant exposure
por: Hiemstra, Steven, et al.
Publicado: (2022)

Disentangling the Trichoderma viridescens complex
por: Jaklitsch, W.M., et al.
Publicado: (2013)

Disentangling entanglements in biopolymer solutions
por: Lang, Philipp, et al.
Publicado: (2018)

Disentangling the strings that organize behavior
por: Louis, Matthieu, et al.
Publicado: (2018)

Disentangling reporting and disease transmission
por: O’Dea, Eamon B., et al.
Publicado: (2018)

Disentangling Mitochondria in Alzheimer’s Disease
por: Johri, Ashu
Publicado: (2021)

Disentangling interoceptive abilities in alexithymia
por: Scarpazza, Cristina, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_6oapbsjkfvifu1tnljdoojr3uq