Revisiting the Old Data of Heat Shock Protein 27 Expression in Squamous Cell Carcinoma: Enigmatic HSP27, More Than Heat Shock

Initially discovered to be induced by heat shock, heat shock protein 27 (HSP27, also called HSPB1), a member of the small HSP family, can help cells better withstand or avoid heat shock damage. After years of studies, HSP27 was gradually found to be extensively engaged in various physiological or pa...

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Detalles Bibliográficos
Autores principales: Zheng, Shutao, Liang, Yan, Li, Lu, Tan, Yiyi, Liu, Qing, Liu, Tao, Lu, Xiaomei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139513/
https://www.ncbi.nlm.nih.gov/pubmed/35626702
http://dx.doi.org/10.3390/cells11101665
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author Zheng, Shutao
Liang, Yan
Li, Lu
Tan, Yiyi
Liu, Qing
Liu, Tao
Lu, Xiaomei
author_facet Zheng, Shutao
Liang, Yan
Li, Lu
Tan, Yiyi
Liu, Qing
Liu, Tao
Lu, Xiaomei
author_sort Zheng, Shutao
collection PubMed
description Initially discovered to be induced by heat shock, heat shock protein 27 (HSP27, also called HSPB1), a member of the small HSP family, can help cells better withstand or avoid heat shock damage. After years of studies, HSP27 was gradually found to be extensively engaged in various physiological or pathophysiological activities. Herein, revisiting the previously published data concerning HSP27, we conducted a critical review of the literature regarding its role in squamous cell carcinoma (SCC) from the perspective of clinicopathological and prognostic significance, excluding studies conducted on adenocarcinoma, which is very different from SCC, to understand the enigmatic role of HSP27 in the tumorigenesis of SCC, including normal mucosa, dysplasia, intraepithelial neoplasm, carcinoma in situ and invasive SCC.
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spelling pubmed-91395132022-05-28 Revisiting the Old Data of Heat Shock Protein 27 Expression in Squamous Cell Carcinoma: Enigmatic HSP27, More Than Heat Shock Zheng, Shutao Liang, Yan Li, Lu Tan, Yiyi Liu, Qing Liu, Tao Lu, Xiaomei Cells Review Initially discovered to be induced by heat shock, heat shock protein 27 (HSP27, also called HSPB1), a member of the small HSP family, can help cells better withstand or avoid heat shock damage. After years of studies, HSP27 was gradually found to be extensively engaged in various physiological or pathophysiological activities. Herein, revisiting the previously published data concerning HSP27, we conducted a critical review of the literature regarding its role in squamous cell carcinoma (SCC) from the perspective of clinicopathological and prognostic significance, excluding studies conducted on adenocarcinoma, which is very different from SCC, to understand the enigmatic role of HSP27 in the tumorigenesis of SCC, including normal mucosa, dysplasia, intraepithelial neoplasm, carcinoma in situ and invasive SCC. MDPI 2022-05-17 /pmc/articles/PMC9139513/ /pubmed/35626702 http://dx.doi.org/10.3390/cells11101665 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zheng, Shutao
Liang, Yan
Li, Lu
Tan, Yiyi
Liu, Qing
Liu, Tao
Lu, Xiaomei
Revisiting the Old Data of Heat Shock Protein 27 Expression in Squamous Cell Carcinoma: Enigmatic HSP27, More Than Heat Shock
title Revisiting the Old Data of Heat Shock Protein 27 Expression in Squamous Cell Carcinoma: Enigmatic HSP27, More Than Heat Shock
title_full Revisiting the Old Data of Heat Shock Protein 27 Expression in Squamous Cell Carcinoma: Enigmatic HSP27, More Than Heat Shock
title_fullStr Revisiting the Old Data of Heat Shock Protein 27 Expression in Squamous Cell Carcinoma: Enigmatic HSP27, More Than Heat Shock
title_full_unstemmed Revisiting the Old Data of Heat Shock Protein 27 Expression in Squamous Cell Carcinoma: Enigmatic HSP27, More Than Heat Shock
title_short Revisiting the Old Data of Heat Shock Protein 27 Expression in Squamous Cell Carcinoma: Enigmatic HSP27, More Than Heat Shock
title_sort revisiting the old data of heat shock protein 27 expression in squamous cell carcinoma: enigmatic hsp27, more than heat shock
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139513/
https://www.ncbi.nlm.nih.gov/pubmed/35626702
http://dx.doi.org/10.3390/cells11101665
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