Induced CAR-Macrophages as a Novel Therapeutic Cell Type for Cancer Immune Cell Therapies

The Chimeric antigen receptor (CAR)-T cell therapy has made inroads in treating hematological malignancies. Nonetheless, there are still multiple hurdles in CAR-T cell therapy for solid tumors. Primary CAR-expressing macrophage cells (CAR-Ms) and induced pluripotent stem cells (iPSCs)-derived CAR-ex...

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Autores principales: Su, Siyu, Lei, Anhua, Wang, Xudong, Lu, Hengxing, Wang, Shuhang, Yang, Yuqi, Li, Ning, Zhang, Yi, Zhang, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139529/
https://www.ncbi.nlm.nih.gov/pubmed/35626689
http://dx.doi.org/10.3390/cells11101652
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author Su, Siyu
Lei, Anhua
Wang, Xudong
Lu, Hengxing
Wang, Shuhang
Yang, Yuqi
Li, Ning
Zhang, Yi
Zhang, Jin
author_facet Su, Siyu
Lei, Anhua
Wang, Xudong
Lu, Hengxing
Wang, Shuhang
Yang, Yuqi
Li, Ning
Zhang, Yi
Zhang, Jin
author_sort Su, Siyu
collection PubMed
description The Chimeric antigen receptor (CAR)-T cell therapy has made inroads in treating hematological malignancies. Nonetheless, there are still multiple hurdles in CAR-T cell therapy for solid tumors. Primary CAR-expressing macrophage cells (CAR-Ms) and induced pluripotent stem cells (iPSCs)-derived CAR-expressing macrophage cells (CAR-iMacs) have emerged as attractive alternatives in our quest for an efficient and inexpensive approach for tumor immune cell therapy. In this review, we list the current state of development of human CAR-macrophages and provide an overview of the crucial functions of human CAR-macrophages in the field of tumor immune cell therapy.
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spelling pubmed-91395292022-05-28 Induced CAR-Macrophages as a Novel Therapeutic Cell Type for Cancer Immune Cell Therapies Su, Siyu Lei, Anhua Wang, Xudong Lu, Hengxing Wang, Shuhang Yang, Yuqi Li, Ning Zhang, Yi Zhang, Jin Cells Perspective The Chimeric antigen receptor (CAR)-T cell therapy has made inroads in treating hematological malignancies. Nonetheless, there are still multiple hurdles in CAR-T cell therapy for solid tumors. Primary CAR-expressing macrophage cells (CAR-Ms) and induced pluripotent stem cells (iPSCs)-derived CAR-expressing macrophage cells (CAR-iMacs) have emerged as attractive alternatives in our quest for an efficient and inexpensive approach for tumor immune cell therapy. In this review, we list the current state of development of human CAR-macrophages and provide an overview of the crucial functions of human CAR-macrophages in the field of tumor immune cell therapy. MDPI 2022-05-16 /pmc/articles/PMC9139529/ /pubmed/35626689 http://dx.doi.org/10.3390/cells11101652 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Perspective
Su, Siyu
Lei, Anhua
Wang, Xudong
Lu, Hengxing
Wang, Shuhang
Yang, Yuqi
Li, Ning
Zhang, Yi
Zhang, Jin
Induced CAR-Macrophages as a Novel Therapeutic Cell Type for Cancer Immune Cell Therapies
title Induced CAR-Macrophages as a Novel Therapeutic Cell Type for Cancer Immune Cell Therapies
title_full Induced CAR-Macrophages as a Novel Therapeutic Cell Type for Cancer Immune Cell Therapies
title_fullStr Induced CAR-Macrophages as a Novel Therapeutic Cell Type for Cancer Immune Cell Therapies
title_full_unstemmed Induced CAR-Macrophages as a Novel Therapeutic Cell Type for Cancer Immune Cell Therapies
title_short Induced CAR-Macrophages as a Novel Therapeutic Cell Type for Cancer Immune Cell Therapies
title_sort induced car-macrophages as a novel therapeutic cell type for cancer immune cell therapies
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139529/
https://www.ncbi.nlm.nih.gov/pubmed/35626689
http://dx.doi.org/10.3390/cells11101652
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