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Bridging Liver Transplantation in the Treatment of Intestinal Failure Associated Liver Disease in Infants—A Bridge Too Far?
Infants with intestinal failure associated liver disease (IFALD) requiring liver and bowel transplant have a high mortality on the transplant waiting list due to the scarcity of the size-matched donor organs. Bridging liver transplantation has been used to allow the children to grow to a reasonable...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139533/ https://www.ncbi.nlm.nih.gov/pubmed/35626876 http://dx.doi.org/10.3390/children9050699 |
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author | Sharif, Abubakar Sharif, Khalid Mirza, Darius F. Gupte, Girish L. |
author_facet | Sharif, Abubakar Sharif, Khalid Mirza, Darius F. Gupte, Girish L. |
author_sort | Sharif, Abubakar |
collection | PubMed |
description | Infants with intestinal failure associated liver disease (IFALD) requiring liver and bowel transplant have a high mortality on the transplant waiting list due to the scarcity of the size-matched donor organs. Bridging liver transplantation has been used to allow the children to grow to a reasonable size so that a combined liver and small bowel transplant could be performed in the future. We report on two children with irreversible intestinal failure (ultra-short bowel syndrome secondary to gastroschisis and microvillous inclusion disease) with IFALD who underwent bridging liver transplantation at our institution. Both patients made a good recovery from their initial surgery. One patient died 6 months following surgery from generalized sepsis, and the other patient survived in good condition to undergo a combined liver and small bowel transplant but died a few days post-transplant. In the current era of scarcity of donor organs, this raises an ethical dilemma for the team involved regarding appropriate utilisation of a scarce resource. |
format | Online Article Text |
id | pubmed-9139533 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91395332022-05-28 Bridging Liver Transplantation in the Treatment of Intestinal Failure Associated Liver Disease in Infants—A Bridge Too Far? Sharif, Abubakar Sharif, Khalid Mirza, Darius F. Gupte, Girish L. Children (Basel) Article Infants with intestinal failure associated liver disease (IFALD) requiring liver and bowel transplant have a high mortality on the transplant waiting list due to the scarcity of the size-matched donor organs. Bridging liver transplantation has been used to allow the children to grow to a reasonable size so that a combined liver and small bowel transplant could be performed in the future. We report on two children with irreversible intestinal failure (ultra-short bowel syndrome secondary to gastroschisis and microvillous inclusion disease) with IFALD who underwent bridging liver transplantation at our institution. Both patients made a good recovery from their initial surgery. One patient died 6 months following surgery from generalized sepsis, and the other patient survived in good condition to undergo a combined liver and small bowel transplant but died a few days post-transplant. In the current era of scarcity of donor organs, this raises an ethical dilemma for the team involved regarding appropriate utilisation of a scarce resource. MDPI 2022-05-10 /pmc/articles/PMC9139533/ /pubmed/35626876 http://dx.doi.org/10.3390/children9050699 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sharif, Abubakar Sharif, Khalid Mirza, Darius F. Gupte, Girish L. Bridging Liver Transplantation in the Treatment of Intestinal Failure Associated Liver Disease in Infants—A Bridge Too Far? |
title | Bridging Liver Transplantation in the Treatment of Intestinal Failure Associated Liver Disease in Infants—A Bridge Too Far? |
title_full | Bridging Liver Transplantation in the Treatment of Intestinal Failure Associated Liver Disease in Infants—A Bridge Too Far? |
title_fullStr | Bridging Liver Transplantation in the Treatment of Intestinal Failure Associated Liver Disease in Infants—A Bridge Too Far? |
title_full_unstemmed | Bridging Liver Transplantation in the Treatment of Intestinal Failure Associated Liver Disease in Infants—A Bridge Too Far? |
title_short | Bridging Liver Transplantation in the Treatment of Intestinal Failure Associated Liver Disease in Infants—A Bridge Too Far? |
title_sort | bridging liver transplantation in the treatment of intestinal failure associated liver disease in infants—a bridge too far? |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139533/ https://www.ncbi.nlm.nih.gov/pubmed/35626876 http://dx.doi.org/10.3390/children9050699 |
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