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Histopathologic Feature of Hyalinization Predicts Recurrence of Conventional/Solid Multicystic Ameloblastomas

The histologic properties of tumors seem to affect their biological behavior, and the same holds good for solid multicystic ameloblastoma (SMA), a benign, locally destructive lesion. Hyalinization is one such histological factor that has been demonstrated to correlate with the biological behavior of...

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Autores principales: Augustine, Dominic, Rao, Roopa S., Surendra, Lakshminarayana, Patil, Shankargouda, Yoithapprabhunath, Thuckanaickenpalayam Ragunathan, Albogami, Sarah, Shamsuddin, Shaheen, Basheer, Sulphi Abdul, Sainudeen, Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139534/
https://www.ncbi.nlm.nih.gov/pubmed/35626270
http://dx.doi.org/10.3390/diagnostics12051114
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author Augustine, Dominic
Rao, Roopa S.
Surendra, Lakshminarayana
Patil, Shankargouda
Yoithapprabhunath, Thuckanaickenpalayam Ragunathan
Albogami, Sarah
Shamsuddin, Shaheen
Basheer, Sulphi Abdul
Sainudeen, Shan
author_facet Augustine, Dominic
Rao, Roopa S.
Surendra, Lakshminarayana
Patil, Shankargouda
Yoithapprabhunath, Thuckanaickenpalayam Ragunathan
Albogami, Sarah
Shamsuddin, Shaheen
Basheer, Sulphi Abdul
Sainudeen, Shan
author_sort Augustine, Dominic
collection PubMed
description The histologic properties of tumors seem to affect their biological behavior, and the same holds good for solid multicystic ameloblastoma (SMA), a benign, locally destructive lesion. Hyalinization is one such histological factor that has been demonstrated to correlate with the biological behavior of neoplasms. The present study aimed to analyze the correlation between the severity of hyalinization (SOH) and the recurrence potential of SMAs. The study was performed on formalin-fixed, paraffin-embedded (FFPE) diagnosed archival cases of SMA, follicular SMA (n = 35) and plexiform SMA (n = 25). The cases were evaluated for SOH and scored from 0–3, and the correlation between SOH and recurrence was analyzed for statistical significance. The clinical parameters of the lesion were analyzed for statistical correlation with recurrence. The SOH significantly correlated with the recurrence of SMA (p = 0.001). The histologic type did not influence the biological behavior of SMA. The location of SMA in the body of the mandible (p = 0.036), multilocular radiolucency (p = 0.001) and root resorption (p = 0.002) also showed strong statistical correlation with recurrence. It is evident from the present study that hyalinization strongly correlates with the biological behavior of SMA. Future studies with advanced investigations could validate the presence of hyalinization and identify the origin of the hyalinized product in SMAs.
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spelling pubmed-91395342022-05-28 Histopathologic Feature of Hyalinization Predicts Recurrence of Conventional/Solid Multicystic Ameloblastomas Augustine, Dominic Rao, Roopa S. Surendra, Lakshminarayana Patil, Shankargouda Yoithapprabhunath, Thuckanaickenpalayam Ragunathan Albogami, Sarah Shamsuddin, Shaheen Basheer, Sulphi Abdul Sainudeen, Shan Diagnostics (Basel) Article The histologic properties of tumors seem to affect their biological behavior, and the same holds good for solid multicystic ameloblastoma (SMA), a benign, locally destructive lesion. Hyalinization is one such histological factor that has been demonstrated to correlate with the biological behavior of neoplasms. The present study aimed to analyze the correlation between the severity of hyalinization (SOH) and the recurrence potential of SMAs. The study was performed on formalin-fixed, paraffin-embedded (FFPE) diagnosed archival cases of SMA, follicular SMA (n = 35) and plexiform SMA (n = 25). The cases were evaluated for SOH and scored from 0–3, and the correlation between SOH and recurrence was analyzed for statistical significance. The clinical parameters of the lesion were analyzed for statistical correlation with recurrence. The SOH significantly correlated with the recurrence of SMA (p = 0.001). The histologic type did not influence the biological behavior of SMA. The location of SMA in the body of the mandible (p = 0.036), multilocular radiolucency (p = 0.001) and root resorption (p = 0.002) also showed strong statistical correlation with recurrence. It is evident from the present study that hyalinization strongly correlates with the biological behavior of SMA. Future studies with advanced investigations could validate the presence of hyalinization and identify the origin of the hyalinized product in SMAs. MDPI 2022-04-29 /pmc/articles/PMC9139534/ /pubmed/35626270 http://dx.doi.org/10.3390/diagnostics12051114 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Augustine, Dominic
Rao, Roopa S.
Surendra, Lakshminarayana
Patil, Shankargouda
Yoithapprabhunath, Thuckanaickenpalayam Ragunathan
Albogami, Sarah
Shamsuddin, Shaheen
Basheer, Sulphi Abdul
Sainudeen, Shan
Histopathologic Feature of Hyalinization Predicts Recurrence of Conventional/Solid Multicystic Ameloblastomas
title Histopathologic Feature of Hyalinization Predicts Recurrence of Conventional/Solid Multicystic Ameloblastomas
title_full Histopathologic Feature of Hyalinization Predicts Recurrence of Conventional/Solid Multicystic Ameloblastomas
title_fullStr Histopathologic Feature of Hyalinization Predicts Recurrence of Conventional/Solid Multicystic Ameloblastomas
title_full_unstemmed Histopathologic Feature of Hyalinization Predicts Recurrence of Conventional/Solid Multicystic Ameloblastomas
title_short Histopathologic Feature of Hyalinization Predicts Recurrence of Conventional/Solid Multicystic Ameloblastomas
title_sort histopathologic feature of hyalinization predicts recurrence of conventional/solid multicystic ameloblastomas
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139534/
https://www.ncbi.nlm.nih.gov/pubmed/35626270
http://dx.doi.org/10.3390/diagnostics12051114
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