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The Regulatory-T-Cell Memory Phenotype: What We Know
In immunology, the discovery of regulatory T (Treg) cells was a major breakthrough. Treg cells play a key role in pregnancy maintenance, in the prevention of autoimmune responses, and in the control of all immune responses, including responses to self cells, cancer, infection, and a transplant. It i...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139615/ https://www.ncbi.nlm.nih.gov/pubmed/35626725 http://dx.doi.org/10.3390/cells11101687 |
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author | Khantakova, Julia N. Bulygin, Aleksey S. Sennikov, Sergey V. |
author_facet | Khantakova, Julia N. Bulygin, Aleksey S. Sennikov, Sergey V. |
author_sort | Khantakova, Julia N. |
collection | PubMed |
description | In immunology, the discovery of regulatory T (Treg) cells was a major breakthrough. Treg cells play a key role in pregnancy maintenance, in the prevention of autoimmune responses, and in the control of all immune responses, including responses to self cells, cancer, infection, and a transplant. It is currently unclear whether Treg cells are capable of long-term memory of an encounter with an antigen. Although the term “immunological memory” usually means an enhanced ability to protect the body from reinfection, the memory of the suppressive activity of Treg cells helps to avoid the state of generalized immunosuppression that may result from the second activation of the immune system. In this review, we would like to discuss the concept of regulatory memory and in which tissues memory Treg cells can perform their functions. |
format | Online Article Text |
id | pubmed-9139615 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91396152022-05-28 The Regulatory-T-Cell Memory Phenotype: What We Know Khantakova, Julia N. Bulygin, Aleksey S. Sennikov, Sergey V. Cells Review In immunology, the discovery of regulatory T (Treg) cells was a major breakthrough. Treg cells play a key role in pregnancy maintenance, in the prevention of autoimmune responses, and in the control of all immune responses, including responses to self cells, cancer, infection, and a transplant. It is currently unclear whether Treg cells are capable of long-term memory of an encounter with an antigen. Although the term “immunological memory” usually means an enhanced ability to protect the body from reinfection, the memory of the suppressive activity of Treg cells helps to avoid the state of generalized immunosuppression that may result from the second activation of the immune system. In this review, we would like to discuss the concept of regulatory memory and in which tissues memory Treg cells can perform their functions. MDPI 2022-05-19 /pmc/articles/PMC9139615/ /pubmed/35626725 http://dx.doi.org/10.3390/cells11101687 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Khantakova, Julia N. Bulygin, Aleksey S. Sennikov, Sergey V. The Regulatory-T-Cell Memory Phenotype: What We Know |
title | The Regulatory-T-Cell Memory Phenotype: What We Know |
title_full | The Regulatory-T-Cell Memory Phenotype: What We Know |
title_fullStr | The Regulatory-T-Cell Memory Phenotype: What We Know |
title_full_unstemmed | The Regulatory-T-Cell Memory Phenotype: What We Know |
title_short | The Regulatory-T-Cell Memory Phenotype: What We Know |
title_sort | regulatory-t-cell memory phenotype: what we know |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139615/ https://www.ncbi.nlm.nih.gov/pubmed/35626725 http://dx.doi.org/10.3390/cells11101687 |
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