Cargando…

The Regulatory-T-Cell Memory Phenotype: What We Know

In immunology, the discovery of regulatory T (Treg) cells was a major breakthrough. Treg cells play a key role in pregnancy maintenance, in the prevention of autoimmune responses, and in the control of all immune responses, including responses to self cells, cancer, infection, and a transplant. It i...

Descripción completa

Detalles Bibliográficos
Autores principales: Khantakova, Julia N., Bulygin, Aleksey S., Sennikov, Sergey V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139615/
https://www.ncbi.nlm.nih.gov/pubmed/35626725
http://dx.doi.org/10.3390/cells11101687
_version_ 1784714900794245120
author Khantakova, Julia N.
Bulygin, Aleksey S.
Sennikov, Sergey V.
author_facet Khantakova, Julia N.
Bulygin, Aleksey S.
Sennikov, Sergey V.
author_sort Khantakova, Julia N.
collection PubMed
description In immunology, the discovery of regulatory T (Treg) cells was a major breakthrough. Treg cells play a key role in pregnancy maintenance, in the prevention of autoimmune responses, and in the control of all immune responses, including responses to self cells, cancer, infection, and a transplant. It is currently unclear whether Treg cells are capable of long-term memory of an encounter with an antigen. Although the term “immunological memory” usually means an enhanced ability to protect the body from reinfection, the memory of the suppressive activity of Treg cells helps to avoid the state of generalized immunosuppression that may result from the second activation of the immune system. In this review, we would like to discuss the concept of regulatory memory and in which tissues memory Treg cells can perform their functions.
format Online
Article
Text
id pubmed-9139615
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-91396152022-05-28 The Regulatory-T-Cell Memory Phenotype: What We Know Khantakova, Julia N. Bulygin, Aleksey S. Sennikov, Sergey V. Cells Review In immunology, the discovery of regulatory T (Treg) cells was a major breakthrough. Treg cells play a key role in pregnancy maintenance, in the prevention of autoimmune responses, and in the control of all immune responses, including responses to self cells, cancer, infection, and a transplant. It is currently unclear whether Treg cells are capable of long-term memory of an encounter with an antigen. Although the term “immunological memory” usually means an enhanced ability to protect the body from reinfection, the memory of the suppressive activity of Treg cells helps to avoid the state of generalized immunosuppression that may result from the second activation of the immune system. In this review, we would like to discuss the concept of regulatory memory and in which tissues memory Treg cells can perform their functions. MDPI 2022-05-19 /pmc/articles/PMC9139615/ /pubmed/35626725 http://dx.doi.org/10.3390/cells11101687 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Khantakova, Julia N.
Bulygin, Aleksey S.
Sennikov, Sergey V.
The Regulatory-T-Cell Memory Phenotype: What We Know
title The Regulatory-T-Cell Memory Phenotype: What We Know
title_full The Regulatory-T-Cell Memory Phenotype: What We Know
title_fullStr The Regulatory-T-Cell Memory Phenotype: What We Know
title_full_unstemmed The Regulatory-T-Cell Memory Phenotype: What We Know
title_short The Regulatory-T-Cell Memory Phenotype: What We Know
title_sort regulatory-t-cell memory phenotype: what we know
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139615/
https://www.ncbi.nlm.nih.gov/pubmed/35626725
http://dx.doi.org/10.3390/cells11101687
work_keys_str_mv AT khantakovajulian theregulatorytcellmemoryphenotypewhatweknow
AT bulyginalekseys theregulatorytcellmemoryphenotypewhatweknow
AT sennikovsergeyv theregulatorytcellmemoryphenotypewhatweknow
AT khantakovajulian regulatorytcellmemoryphenotypewhatweknow
AT bulyginalekseys regulatorytcellmemoryphenotypewhatweknow
AT sennikovsergeyv regulatorytcellmemoryphenotypewhatweknow