Frequent 4EBP1 Amplification Induces Synthetic Dependence on FGFR Signaling in Cancer

SIMPLE SUMMARY: Our work establishes that amplification of 4EBP1, as a part of Chr. 8p11, creates a synthetic dependency on FGFR1 signaling in cancer. 4EBP1 is phosphorylated by FGFR1 and PI3K signaling, and accordingly cancer with 4EBP1-FGFR1 amplification is more sensitive to FGFR1 and PI3K inhibi...

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Detalles Bibliográficos
Autores principales: Mohan, Prathibha, Pasion, Joyce, Ciriello, Giovanni, Lailler, Nathalie, de Stanchina, Elisa, Viale, Agnes, van den Berg, Anke, Diepstra, Arjan, Wendel, Hans-Guido, Sanghvi, Viraj R., Singh, Kamini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139685/
https://www.ncbi.nlm.nih.gov/pubmed/35626002
http://dx.doi.org/10.3390/cancers14102397

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139685/
https://www.ncbi.nlm.nih.gov/pubmed/35626002
http://dx.doi.org/10.3390/cancers14102397

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