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Evaluation of Intranasal Midazolam for Pediatric Sedation during the Suturing of Traumatic Lacerations: A Systematic Review

Objective: The objective of this study was to evaluate the efficacy and safety of intranasal midazolam as part of a paediatric sedation and analgesic procedure during the suturing of traumatic lacerations in paediatric emergency departments. Methodology: A systematic review of clinical trials was co...

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Autores principales: Gómez-Manzano, Francisco Javier, Laredo-Aguilera, José Alberto, Cobo-Cuenca, Ana Isabel, Rabanales-Sotos, Joseba, Rodríguez-Cañamero, Sergio, Martín-Espinosa, Noelia, Carmona-Torres, Juan Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139737/
https://www.ncbi.nlm.nih.gov/pubmed/35626821
http://dx.doi.org/10.3390/children9050644
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author Gómez-Manzano, Francisco Javier
Laredo-Aguilera, José Alberto
Cobo-Cuenca, Ana Isabel
Rabanales-Sotos, Joseba
Rodríguez-Cañamero, Sergio
Martín-Espinosa, Noelia
Carmona-Torres, Juan Manuel
author_facet Gómez-Manzano, Francisco Javier
Laredo-Aguilera, José Alberto
Cobo-Cuenca, Ana Isabel
Rabanales-Sotos, Joseba
Rodríguez-Cañamero, Sergio
Martín-Espinosa, Noelia
Carmona-Torres, Juan Manuel
author_sort Gómez-Manzano, Francisco Javier
collection PubMed
description Objective: The objective of this study was to evaluate the efficacy and safety of intranasal midazolam as part of a paediatric sedation and analgesic procedure during the suturing of traumatic lacerations in paediatric emergency departments. Methodology: A systematic review of clinical trials was completed in July 2021. The databases consulted were PUBMED, SCOPUS, WEB OF SCIENCE, NICE and Virtual Health Library. Eligibility criteria: randomised and nonrandomised clinical trials. Two independent, blinded reviewers performed the selection and data extraction. The participants were 746 children, of whom, 377 received intranasal midazolam. All of the children were admitted to an emergency department for traumatic lacerations that required suturing. The quality of the articles was evaluated with the Jadad scale. This systematic review was conducted according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Results: Nine studies were included in the review. The intranasal administration of midazolam in healthy children produces anxiolysis and minimal/moderate sedation without serious side effects. Although there are combinations of parenteral drugs that produce deeper sedation, they also have greater adverse effects. No significant differences in the initiation of sedation and the suture procedure were found between the intranasal route and the parenteral route. Conclusions: The use of intranasal midazolam in healthy children produces sufficiently intense and long-lasting sedation to allow for the suturing of traumatic lacerations that do not present other complications; therefore, this drug can be used effectively in paediatric emergency departments.
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spelling pubmed-91397372022-05-28 Evaluation of Intranasal Midazolam for Pediatric Sedation during the Suturing of Traumatic Lacerations: A Systematic Review Gómez-Manzano, Francisco Javier Laredo-Aguilera, José Alberto Cobo-Cuenca, Ana Isabel Rabanales-Sotos, Joseba Rodríguez-Cañamero, Sergio Martín-Espinosa, Noelia Carmona-Torres, Juan Manuel Children (Basel) Systematic Review Objective: The objective of this study was to evaluate the efficacy and safety of intranasal midazolam as part of a paediatric sedation and analgesic procedure during the suturing of traumatic lacerations in paediatric emergency departments. Methodology: A systematic review of clinical trials was completed in July 2021. The databases consulted were PUBMED, SCOPUS, WEB OF SCIENCE, NICE and Virtual Health Library. Eligibility criteria: randomised and nonrandomised clinical trials. Two independent, blinded reviewers performed the selection and data extraction. The participants were 746 children, of whom, 377 received intranasal midazolam. All of the children were admitted to an emergency department for traumatic lacerations that required suturing. The quality of the articles was evaluated with the Jadad scale. This systematic review was conducted according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Results: Nine studies were included in the review. The intranasal administration of midazolam in healthy children produces anxiolysis and minimal/moderate sedation without serious side effects. Although there are combinations of parenteral drugs that produce deeper sedation, they also have greater adverse effects. No significant differences in the initiation of sedation and the suture procedure were found between the intranasal route and the parenteral route. Conclusions: The use of intranasal midazolam in healthy children produces sufficiently intense and long-lasting sedation to allow for the suturing of traumatic lacerations that do not present other complications; therefore, this drug can be used effectively in paediatric emergency departments. MDPI 2022-04-29 /pmc/articles/PMC9139737/ /pubmed/35626821 http://dx.doi.org/10.3390/children9050644 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Gómez-Manzano, Francisco Javier
Laredo-Aguilera, José Alberto
Cobo-Cuenca, Ana Isabel
Rabanales-Sotos, Joseba
Rodríguez-Cañamero, Sergio
Martín-Espinosa, Noelia
Carmona-Torres, Juan Manuel
Evaluation of Intranasal Midazolam for Pediatric Sedation during the Suturing of Traumatic Lacerations: A Systematic Review
title Evaluation of Intranasal Midazolam for Pediatric Sedation during the Suturing of Traumatic Lacerations: A Systematic Review
title_full Evaluation of Intranasal Midazolam for Pediatric Sedation during the Suturing of Traumatic Lacerations: A Systematic Review
title_fullStr Evaluation of Intranasal Midazolam for Pediatric Sedation during the Suturing of Traumatic Lacerations: A Systematic Review
title_full_unstemmed Evaluation of Intranasal Midazolam for Pediatric Sedation during the Suturing of Traumatic Lacerations: A Systematic Review
title_short Evaluation of Intranasal Midazolam for Pediatric Sedation during the Suturing of Traumatic Lacerations: A Systematic Review
title_sort evaluation of intranasal midazolam for pediatric sedation during the suturing of traumatic lacerations: a systematic review
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139737/
https://www.ncbi.nlm.nih.gov/pubmed/35626821
http://dx.doi.org/10.3390/children9050644
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