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Cardiovascular Manifestations in Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with COVID-19 According to Age

Cardiac involvement in multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus-19 disease is often observed with a high risk of heart failure. The aim is to describe cardiovascular involvement, management and early outcome in MIS-C by comparing cardiovascular manifestations...

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Autores principales: Campanello, Claudia, Mercuri, Claudia, Derchi, Maria, Trocchio, Gianluca, Consolaro, Alessandro, Caorsi, Roberta, Ravelli, Angelo, Rimini, Alessandro, Marasini, Maurizio, Gattorno, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139768/
https://www.ncbi.nlm.nih.gov/pubmed/35626760
http://dx.doi.org/10.3390/children9050583
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author Campanello, Claudia
Mercuri, Claudia
Derchi, Maria
Trocchio, Gianluca
Consolaro, Alessandro
Caorsi, Roberta
Ravelli, Angelo
Rimini, Alessandro
Marasini, Maurizio
Gattorno, Marco
author_facet Campanello, Claudia
Mercuri, Claudia
Derchi, Maria
Trocchio, Gianluca
Consolaro, Alessandro
Caorsi, Roberta
Ravelli, Angelo
Rimini, Alessandro
Marasini, Maurizio
Gattorno, Marco
author_sort Campanello, Claudia
collection PubMed
description Cardiac involvement in multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus-19 disease is often observed with a high risk of heart failure. The aim is to describe cardiovascular involvement, management and early outcome in MIS-C by comparing cardiovascular manifestations in children younger and older than 6 years old. This retrospective observational study included 25 children with MIS-C, admitted to a single pediatric center between March 2020 and September 2021. The median age was 5 years (13 patients under 6 years and 12 over 6 years); coronary artery abnormalities were observed in 77% of preschoolers, with small and medium aneurysms in half of the cases and two cases of mild ventricular dysfunction. School-age children presented myopericardial involvement with mild to moderate ventricular dysfunction in 67% of cases, and two cases of transient coronary dilatation. There was a significant NT-pro-BNP and inflammatory markers increase in 25 of the patients, and mild elevation of troponin I in 9. All patients were treated with intravenous immunoglobulin and corticosteroids, and 8 with anakinra. None of the patients needed inotropes or intensive care unit admission. Our study shows the frequent cardiovascular involvement in MIS-C with a peculiar distribution, according to different age group: coronary artery anomalies were more frequent in the younger group, and myopericardial disease in the older one. A prompt multitarget, anti-inflammatory therapy could probably contribute to a favorable outcome.
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spelling pubmed-91397682022-05-28 Cardiovascular Manifestations in Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with COVID-19 According to Age Campanello, Claudia Mercuri, Claudia Derchi, Maria Trocchio, Gianluca Consolaro, Alessandro Caorsi, Roberta Ravelli, Angelo Rimini, Alessandro Marasini, Maurizio Gattorno, Marco Children (Basel) Article Cardiac involvement in multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus-19 disease is often observed with a high risk of heart failure. The aim is to describe cardiovascular involvement, management and early outcome in MIS-C by comparing cardiovascular manifestations in children younger and older than 6 years old. This retrospective observational study included 25 children with MIS-C, admitted to a single pediatric center between March 2020 and September 2021. The median age was 5 years (13 patients under 6 years and 12 over 6 years); coronary artery abnormalities were observed in 77% of preschoolers, with small and medium aneurysms in half of the cases and two cases of mild ventricular dysfunction. School-age children presented myopericardial involvement with mild to moderate ventricular dysfunction in 67% of cases, and two cases of transient coronary dilatation. There was a significant NT-pro-BNP and inflammatory markers increase in 25 of the patients, and mild elevation of troponin I in 9. All patients were treated with intravenous immunoglobulin and corticosteroids, and 8 with anakinra. None of the patients needed inotropes or intensive care unit admission. Our study shows the frequent cardiovascular involvement in MIS-C with a peculiar distribution, according to different age group: coronary artery anomalies were more frequent in the younger group, and myopericardial disease in the older one. A prompt multitarget, anti-inflammatory therapy could probably contribute to a favorable outcome. MDPI 2022-04-20 /pmc/articles/PMC9139768/ /pubmed/35626760 http://dx.doi.org/10.3390/children9050583 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Campanello, Claudia
Mercuri, Claudia
Derchi, Maria
Trocchio, Gianluca
Consolaro, Alessandro
Caorsi, Roberta
Ravelli, Angelo
Rimini, Alessandro
Marasini, Maurizio
Gattorno, Marco
Cardiovascular Manifestations in Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with COVID-19 According to Age
title Cardiovascular Manifestations in Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with COVID-19 According to Age
title_full Cardiovascular Manifestations in Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with COVID-19 According to Age
title_fullStr Cardiovascular Manifestations in Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with COVID-19 According to Age
title_full_unstemmed Cardiovascular Manifestations in Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with COVID-19 According to Age
title_short Cardiovascular Manifestations in Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with COVID-19 According to Age
title_sort cardiovascular manifestations in multisystem inflammatory syndrome in children (mis-c) associated with covid-19 according to age
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139768/
https://www.ncbi.nlm.nih.gov/pubmed/35626760
http://dx.doi.org/10.3390/children9050583
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