Performance Evaluation of a Rapid Antigen Test (RAT) during Omicron Pandemic Wave in Greece, Conducted by Different Personnel, and Comparison with Performance in Previous Wave (Alpha Variant) Period

Due to the prevailing ambiguity regarding the performance of rapid antigen tests (RATs) for B.1.1.529 (Omicron) variant diagnosis, a commercial RAT was evaluated in the emergency ward of a general hospital in Larissa, Central Greece. The sampling and the evaluation were repeated twice by different p...

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Autores principales: Kyritsi, Maria A., Speletas, Matthaios, Mouchtouri, Varvara, Vachtsioli, Evangelia, Babalis, Dimitrios, Kouliou, Olympia, Tsispara, Anastasia, Tseroni, Maria, Hadjichristodoulou, Christos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139779/
https://www.ncbi.nlm.nih.gov/pubmed/35626204
http://dx.doi.org/10.3390/diagnostics12051048
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author Kyritsi, Maria A.
Speletas, Matthaios
Mouchtouri, Varvara
Vachtsioli, Evangelia
Babalis, Dimitrios
Kouliou, Olympia
Tsispara, Anastasia
Tseroni, Maria
Hadjichristodoulou, Christos
author_facet Kyritsi, Maria A.
Speletas, Matthaios
Mouchtouri, Varvara
Vachtsioli, Evangelia
Babalis, Dimitrios
Kouliou, Olympia
Tsispara, Anastasia
Tseroni, Maria
Hadjichristodoulou, Christos
author_sort Kyritsi, Maria A.
collection PubMed
description Due to the prevailing ambiguity regarding the performance of rapid antigen tests (RATs) for B.1.1.529 (Omicron) variant diagnosis, a commercial RAT was evaluated in the emergency ward of a general hospital in Larissa, Central Greece. The sampling and the evaluation were repeated twice by different personnel. Discordance between the two samplings was observed regarding the sensitivity (47.5%, 95% CI: 39.0–56.1 vs. 78.6%, 95% CI: 69.1–86.2) and specificity (93.8%, 95% CI: 86.0–97.9 vs. 100.0%, 95% CI: 93.3–100.0) of the RAT. Furthermore, the test displayed slightly lower sensitivity (78.6% vs. 85.5%, 95% CI: 79.1–90.5) compared to its initial evaluation that was conducted by our team when the B.1.1.7 (Alpha) variant was dominant.
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spelling pubmed-91397792022-05-28 Performance Evaluation of a Rapid Antigen Test (RAT) during Omicron Pandemic Wave in Greece, Conducted by Different Personnel, and Comparison with Performance in Previous Wave (Alpha Variant) Period Kyritsi, Maria A. Speletas, Matthaios Mouchtouri, Varvara Vachtsioli, Evangelia Babalis, Dimitrios Kouliou, Olympia Tsispara, Anastasia Tseroni, Maria Hadjichristodoulou, Christos Diagnostics (Basel) Communication Due to the prevailing ambiguity regarding the performance of rapid antigen tests (RATs) for B.1.1.529 (Omicron) variant diagnosis, a commercial RAT was evaluated in the emergency ward of a general hospital in Larissa, Central Greece. The sampling and the evaluation were repeated twice by different personnel. Discordance between the two samplings was observed regarding the sensitivity (47.5%, 95% CI: 39.0–56.1 vs. 78.6%, 95% CI: 69.1–86.2) and specificity (93.8%, 95% CI: 86.0–97.9 vs. 100.0%, 95% CI: 93.3–100.0) of the RAT. Furthermore, the test displayed slightly lower sensitivity (78.6% vs. 85.5%, 95% CI: 79.1–90.5) compared to its initial evaluation that was conducted by our team when the B.1.1.7 (Alpha) variant was dominant. MDPI 2022-04-21 /pmc/articles/PMC9139779/ /pubmed/35626204 http://dx.doi.org/10.3390/diagnostics12051048 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Kyritsi, Maria A.
Speletas, Matthaios
Mouchtouri, Varvara
Vachtsioli, Evangelia
Babalis, Dimitrios
Kouliou, Olympia
Tsispara, Anastasia
Tseroni, Maria
Hadjichristodoulou, Christos
Performance Evaluation of a Rapid Antigen Test (RAT) during Omicron Pandemic Wave in Greece, Conducted by Different Personnel, and Comparison with Performance in Previous Wave (Alpha Variant) Period
title Performance Evaluation of a Rapid Antigen Test (RAT) during Omicron Pandemic Wave in Greece, Conducted by Different Personnel, and Comparison with Performance in Previous Wave (Alpha Variant) Period
title_full Performance Evaluation of a Rapid Antigen Test (RAT) during Omicron Pandemic Wave in Greece, Conducted by Different Personnel, and Comparison with Performance in Previous Wave (Alpha Variant) Period
title_fullStr Performance Evaluation of a Rapid Antigen Test (RAT) during Omicron Pandemic Wave in Greece, Conducted by Different Personnel, and Comparison with Performance in Previous Wave (Alpha Variant) Period
title_full_unstemmed Performance Evaluation of a Rapid Antigen Test (RAT) during Omicron Pandemic Wave in Greece, Conducted by Different Personnel, and Comparison with Performance in Previous Wave (Alpha Variant) Period
title_short Performance Evaluation of a Rapid Antigen Test (RAT) during Omicron Pandemic Wave in Greece, Conducted by Different Personnel, and Comparison with Performance in Previous Wave (Alpha Variant) Period
title_sort performance evaluation of a rapid antigen test (rat) during omicron pandemic wave in greece, conducted by different personnel, and comparison with performance in previous wave (alpha variant) period
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139779/
https://www.ncbi.nlm.nih.gov/pubmed/35626204
http://dx.doi.org/10.3390/diagnostics12051048
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