Cargando…

COVID-19 Vaccine—A Potential Trigger for MOGAD Transverse Myelitis in a Teenager—A Case Report and a Review of the Literature

MOGAD-transverse myelitis is a rare disorder in children and adults, but with a higher incidence in pediatric patients. We report a case of MOGAD-transverse myelitis in a boy who was admitted to hospital with bilateral motor deficit of the lower limbs associated with the impossibility of defecating...

Descripción completa

Detalles Bibliográficos
Autores principales: Mărginean, Cristina Oana, Meliț, Lorena Elena, Cucuiet, Maria Teodora, Cucuiet, Monica, Rațiu, Mihaela, Săsăran, Maria Oana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139812/
https://www.ncbi.nlm.nih.gov/pubmed/35626851
http://dx.doi.org/10.3390/children9050674
_version_ 1784714947024912384
author Mărginean, Cristina Oana
Meliț, Lorena Elena
Cucuiet, Maria Teodora
Cucuiet, Monica
Rațiu, Mihaela
Săsăran, Maria Oana
author_facet Mărginean, Cristina Oana
Meliț, Lorena Elena
Cucuiet, Maria Teodora
Cucuiet, Monica
Rațiu, Mihaela
Săsăran, Maria Oana
author_sort Mărginean, Cristina Oana
collection PubMed
description MOGAD-transverse myelitis is a rare disorder in children and adults, but with a higher incidence in pediatric patients. We report a case of MOGAD-transverse myelitis in a boy who was admitted to hospital with bilateral motor deficit of the lower limbs associated with the impossibility of defecating and urinating. The symptoms progressively developed with severe fatigue within the week prior to admission, with the impossibility to stand occurring 36 h before admission. The anamnesis found that he was vaccinated for COVID-19 approximately 6 weeks before admission to our clinic. The laboratory tests revealed a normal complete cellular blood count, without any signs of inflammation or infection, except for both cryoglobulins and IgG anti-MOG antibodies. MRI showed a T2 hypersignal on vertebral segments C2-C5, Th2-Th5 and Th7-Th11, confirming the diagnosis of longitudinally extensive transverse myelitis. The patient received intravenous high-dose methylprednisolone (1 g) for 5 days, associated with prophylactic antibiotic treatment, subcutaneous low-molecular-weight heparin and other supportive treatment. The patient was discharged on the 12th day of admission, able to walk without support and with no bladder or bowel dysfunction. We can conclude that an early diagnosis was essential for improving the patient’s long-term outcome.
format Online
Article
Text
id pubmed-9139812
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-91398122022-05-28 COVID-19 Vaccine—A Potential Trigger for MOGAD Transverse Myelitis in a Teenager—A Case Report and a Review of the Literature Mărginean, Cristina Oana Meliț, Lorena Elena Cucuiet, Maria Teodora Cucuiet, Monica Rațiu, Mihaela Săsăran, Maria Oana Children (Basel) Case Report MOGAD-transverse myelitis is a rare disorder in children and adults, but with a higher incidence in pediatric patients. We report a case of MOGAD-transverse myelitis in a boy who was admitted to hospital with bilateral motor deficit of the lower limbs associated with the impossibility of defecating and urinating. The symptoms progressively developed with severe fatigue within the week prior to admission, with the impossibility to stand occurring 36 h before admission. The anamnesis found that he was vaccinated for COVID-19 approximately 6 weeks before admission to our clinic. The laboratory tests revealed a normal complete cellular blood count, without any signs of inflammation or infection, except for both cryoglobulins and IgG anti-MOG antibodies. MRI showed a T2 hypersignal on vertebral segments C2-C5, Th2-Th5 and Th7-Th11, confirming the diagnosis of longitudinally extensive transverse myelitis. The patient received intravenous high-dose methylprednisolone (1 g) for 5 days, associated with prophylactic antibiotic treatment, subcutaneous low-molecular-weight heparin and other supportive treatment. The patient was discharged on the 12th day of admission, able to walk without support and with no bladder or bowel dysfunction. We can conclude that an early diagnosis was essential for improving the patient’s long-term outcome. MDPI 2022-05-06 /pmc/articles/PMC9139812/ /pubmed/35626851 http://dx.doi.org/10.3390/children9050674 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Mărginean, Cristina Oana
Meliț, Lorena Elena
Cucuiet, Maria Teodora
Cucuiet, Monica
Rațiu, Mihaela
Săsăran, Maria Oana
COVID-19 Vaccine—A Potential Trigger for MOGAD Transverse Myelitis in a Teenager—A Case Report and a Review of the Literature
title COVID-19 Vaccine—A Potential Trigger for MOGAD Transverse Myelitis in a Teenager—A Case Report and a Review of the Literature
title_full COVID-19 Vaccine—A Potential Trigger for MOGAD Transverse Myelitis in a Teenager—A Case Report and a Review of the Literature
title_fullStr COVID-19 Vaccine—A Potential Trigger for MOGAD Transverse Myelitis in a Teenager—A Case Report and a Review of the Literature
title_full_unstemmed COVID-19 Vaccine—A Potential Trigger for MOGAD Transverse Myelitis in a Teenager—A Case Report and a Review of the Literature
title_short COVID-19 Vaccine—A Potential Trigger for MOGAD Transverse Myelitis in a Teenager—A Case Report and a Review of the Literature
title_sort covid-19 vaccine—a potential trigger for mogad transverse myelitis in a teenager—a case report and a review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139812/
https://www.ncbi.nlm.nih.gov/pubmed/35626851
http://dx.doi.org/10.3390/children9050674
work_keys_str_mv AT margineancristinaoana covid19vaccineapotentialtriggerformogadtransversemyelitisinateenageracasereportandareviewoftheliterature
AT melitlorenaelena covid19vaccineapotentialtriggerformogadtransversemyelitisinateenageracasereportandareviewoftheliterature
AT cucuietmariateodora covid19vaccineapotentialtriggerformogadtransversemyelitisinateenageracasereportandareviewoftheliterature
AT cucuietmonica covid19vaccineapotentialtriggerformogadtransversemyelitisinateenageracasereportandareviewoftheliterature
AT ratiumihaela covid19vaccineapotentialtriggerformogadtransversemyelitisinateenageracasereportandareviewoftheliterature
AT sasaranmariaoana covid19vaccineapotentialtriggerformogadtransversemyelitisinateenageracasereportandareviewoftheliterature