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SGK1 in Cancer: Biomarker and Drug Target

Serum- and glucocorticoid-regulated kinases (SGKs) are members of the AGC family of serine/threonine kinases, consisting of three isoforms: SGK1, SGK2, and SGK3. SGK1 was initially cloned as a gene transcriptionally stimulated by serum and glucocorticoids in rat mammary tumor cells. It is upregulate...

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Autores principales: Cicenas, Jonas, Meskinyte-Kausiliene, Edita, Jukna, Vigilijus, Rimkus, Arnas, Simkus, Jokubas, Soderholm, Diana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139822/
https://www.ncbi.nlm.nih.gov/pubmed/35625991
http://dx.doi.org/10.3390/cancers14102385
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author Cicenas, Jonas
Meskinyte-Kausiliene, Edita
Jukna, Vigilijus
Rimkus, Arnas
Simkus, Jokubas
Soderholm, Diana
author_facet Cicenas, Jonas
Meskinyte-Kausiliene, Edita
Jukna, Vigilijus
Rimkus, Arnas
Simkus, Jokubas
Soderholm, Diana
author_sort Cicenas, Jonas
collection PubMed
description Serum- and glucocorticoid-regulated kinases (SGKs) are members of the AGC family of serine/threonine kinases, consisting of three isoforms: SGK1, SGK2, and SGK3. SGK1 was initially cloned as a gene transcriptionally stimulated by serum and glucocorticoids in rat mammary tumor cells. It is upregulated in some cancers and downregulated in others. SGK1 increases tumor cell survival, adhesiveness, invasiveness, motility, and epithelial to mesenchymal transition. It stimulates tumor growth by mechanisms such as activation of K(+) channels and Ca(2+) channels, Na(+)/H(+) exchanger, amino acid and glucose transporters, downregulation of Foxo3a and p53, and upregulation of β-catenin and NFκB. This chapter focuses on major aspects of SGK1 involvement in cancer, its use as biomarker as well as potential therapeutic target.
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spelling pubmed-91398222022-05-28 SGK1 in Cancer: Biomarker and Drug Target Cicenas, Jonas Meskinyte-Kausiliene, Edita Jukna, Vigilijus Rimkus, Arnas Simkus, Jokubas Soderholm, Diana Cancers (Basel) Commentary Serum- and glucocorticoid-regulated kinases (SGKs) are members of the AGC family of serine/threonine kinases, consisting of three isoforms: SGK1, SGK2, and SGK3. SGK1 was initially cloned as a gene transcriptionally stimulated by serum and glucocorticoids in rat mammary tumor cells. It is upregulated in some cancers and downregulated in others. SGK1 increases tumor cell survival, adhesiveness, invasiveness, motility, and epithelial to mesenchymal transition. It stimulates tumor growth by mechanisms such as activation of K(+) channels and Ca(2+) channels, Na(+)/H(+) exchanger, amino acid and glucose transporters, downregulation of Foxo3a and p53, and upregulation of β-catenin and NFκB. This chapter focuses on major aspects of SGK1 involvement in cancer, its use as biomarker as well as potential therapeutic target. MDPI 2022-05-12 /pmc/articles/PMC9139822/ /pubmed/35625991 http://dx.doi.org/10.3390/cancers14102385 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Commentary
Cicenas, Jonas
Meskinyte-Kausiliene, Edita
Jukna, Vigilijus
Rimkus, Arnas
Simkus, Jokubas
Soderholm, Diana
SGK1 in Cancer: Biomarker and Drug Target
title SGK1 in Cancer: Biomarker and Drug Target
title_full SGK1 in Cancer: Biomarker and Drug Target
title_fullStr SGK1 in Cancer: Biomarker and Drug Target
title_full_unstemmed SGK1 in Cancer: Biomarker and Drug Target
title_short SGK1 in Cancer: Biomarker and Drug Target
title_sort sgk1 in cancer: biomarker and drug target
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139822/
https://www.ncbi.nlm.nih.gov/pubmed/35625991
http://dx.doi.org/10.3390/cancers14102385
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