Current Therapeutic Landscape and Safety Roadmap for Targeting the Aryl Hydrocarbon Receptor in Inflammatory Gastrointestinal Indications

Target modulation of the AhR for inflammatory gastrointestinal (GI) conditions holds great promise but also the potential for safety liabilities both within and beyond the GI tract. The ubiquitous expression of the AhR across mammalian tissues coupled with its role in diverse signaling pathways make...

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Detalles Bibliográficos
Autores principales: Faber, Samantha C., Lahoti, Tejas S., Taylor, Ewan R., Lewis, Lauren, Sapiro, Jessica M., Toledo Sales, Vicencia, Dragan, Yvonne P., Jeffy, Brandon D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139855/
https://www.ncbi.nlm.nih.gov/pubmed/35626744
http://dx.doi.org/10.3390/cells11101708

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