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Perceived Stress in Hepatitis C Virus Infected Patients under the DAA-Based Therapy

The Hepatitis C Virus (HCV) infection often associates medical and mental health conditions which lead to increased levels of distress. Our study aimed at assessing the level of perceived stress on a sample of 90 HCV infected patients treated with Direct-Acting Antiviral (DAA) agents for 12 weeks, a...

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Autores principales: Danilescu, Claudia Monica, Ionescu, Mihaela, Sandulescu, Daniela Larisa, Pirlog, Mihail Cristian, Streba, Costin Teodor, Rogoveanu, Ion
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139880/
https://www.ncbi.nlm.nih.gov/pubmed/35626332
http://dx.doi.org/10.3390/diagnostics12051177
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author Danilescu, Claudia Monica
Ionescu, Mihaela
Sandulescu, Daniela Larisa
Pirlog, Mihail Cristian
Streba, Costin Teodor
Rogoveanu, Ion
author_facet Danilescu, Claudia Monica
Ionescu, Mihaela
Sandulescu, Daniela Larisa
Pirlog, Mihail Cristian
Streba, Costin Teodor
Rogoveanu, Ion
author_sort Danilescu, Claudia Monica
collection PubMed
description The Hepatitis C Virus (HCV) infection often associates medical and mental health conditions which lead to increased levels of distress. Our study aimed at assessing the level of perceived stress on a sample of 90 HCV infected patients treated with Direct-Acting Antiviral (DAA) agents for 12 weeks, and its possible correlations with clinical and evolutionary elements. The evaluation was conducted in three phases: before administration of the DAAs (BSL), at the End of the Treatment (EOT), and 24 weeks after the BSL (Sustained Viral Response—SVR). The perceived stress was measured using the Perceived Stress Scale (PSS). The efficiency of the DAA treatment reduced the levels of stress (98.99% moderate and high stress at BSL to 70.00% at SVR). It was observed, for the entire study period (BSL to SVR), that the decrease in the perceived stress severity was significantly associated with demographic items such as gender (p < 0.01), urban environment (p < 0.001), the age of the subjects (p < 0.05), and clinical data such as F4 degree of fibrosis (p = 0.001) and overweight or obesity class II (p < 0.01). The perceived stress is directly associated with the severity of the HCV infection, and it could be significantly lowered by an efficient therapeutic approach, as DAAs are nowadays.
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spelling pubmed-91398802022-05-28 Perceived Stress in Hepatitis C Virus Infected Patients under the DAA-Based Therapy Danilescu, Claudia Monica Ionescu, Mihaela Sandulescu, Daniela Larisa Pirlog, Mihail Cristian Streba, Costin Teodor Rogoveanu, Ion Diagnostics (Basel) Article The Hepatitis C Virus (HCV) infection often associates medical and mental health conditions which lead to increased levels of distress. Our study aimed at assessing the level of perceived stress on a sample of 90 HCV infected patients treated with Direct-Acting Antiviral (DAA) agents for 12 weeks, and its possible correlations with clinical and evolutionary elements. The evaluation was conducted in three phases: before administration of the DAAs (BSL), at the End of the Treatment (EOT), and 24 weeks after the BSL (Sustained Viral Response—SVR). The perceived stress was measured using the Perceived Stress Scale (PSS). The efficiency of the DAA treatment reduced the levels of stress (98.99% moderate and high stress at BSL to 70.00% at SVR). It was observed, for the entire study period (BSL to SVR), that the decrease in the perceived stress severity was significantly associated with demographic items such as gender (p < 0.01), urban environment (p < 0.001), the age of the subjects (p < 0.05), and clinical data such as F4 degree of fibrosis (p = 0.001) and overweight or obesity class II (p < 0.01). The perceived stress is directly associated with the severity of the HCV infection, and it could be significantly lowered by an efficient therapeutic approach, as DAAs are nowadays. MDPI 2022-05-09 /pmc/articles/PMC9139880/ /pubmed/35626332 http://dx.doi.org/10.3390/diagnostics12051177 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Danilescu, Claudia Monica
Ionescu, Mihaela
Sandulescu, Daniela Larisa
Pirlog, Mihail Cristian
Streba, Costin Teodor
Rogoveanu, Ion
Perceived Stress in Hepatitis C Virus Infected Patients under the DAA-Based Therapy
title Perceived Stress in Hepatitis C Virus Infected Patients under the DAA-Based Therapy
title_full Perceived Stress in Hepatitis C Virus Infected Patients under the DAA-Based Therapy
title_fullStr Perceived Stress in Hepatitis C Virus Infected Patients under the DAA-Based Therapy
title_full_unstemmed Perceived Stress in Hepatitis C Virus Infected Patients under the DAA-Based Therapy
title_short Perceived Stress in Hepatitis C Virus Infected Patients under the DAA-Based Therapy
title_sort perceived stress in hepatitis c virus infected patients under the daa-based therapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139880/
https://www.ncbi.nlm.nih.gov/pubmed/35626332
http://dx.doi.org/10.3390/diagnostics12051177
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