Cargando…

Unveiling the Function of the Mitochondrial Filament-Forming Protein LACTB in Lipid Metabolism and Cancer

LACTB is a relatively unknown mitochondrial protein structurally related to the bacterial penicillin-binding and beta-lactamase superfamily of serine proteases. LACTB has recently gained an increased interest due to its potential role in lipid metabolism and tumorigenesis. To date, around ninety stu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cascone, Annunziata, Lalowski, Maciej, Lindholm, Dan, Eriksson, Ove
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139886/ https://www.ncbi.nlm.nih.gov/pubmed/35626737 http://dx.doi.org/10.3390/cells11101703

Ejemplares similares

Commentary: LACTB is a tumour suppressor that modulates lipid metabolism and cell state
por: Eriksson, Ove, et al.
Publicado: (2017)

Destabilization of the Outer and Inner Mitochondrial Membranes by Core and Linker Histones
por: Cascone, Annunziata, et al.
Publicado: (2012)

Lactate-Induced Glucose Output Is Unchanged by Metformin at a Therapeutic Concentration – A Mass Spectrometry Imaging Study of the Perfused Rat Liver
por: Calza, Giulio, et al.
Publicado: (2018)

The structure of the human LACTB filament reveals the mechanisms of assembly and membrane binding
por: Bennett, Jeremy A., et al.
Publicado: (2022)

Overexpression of LACTB, a Mitochondrial Protein That Inhibits Proliferation and Invasion in Glioma Cells
por: Li, Hai-Tao, et al.
Publicado: (2019)

LACTB, a Metabolic Therapeutic Target in Clinical Cancer Application
por: Li, Xiaohua, et al.
Publicado: (2022)

c-Abl Inhibitors Enable Insights into the Pathophysiology and Neuroprotection in Parkinson’s Disease
por: Lindholm, Dan, et al.
Publicado: (2016)

Identification of LACTB2, a metallo-β-lactamase protein, as a human mitochondrial endoribonuclease
por: Levy, Shiri, et al.
Publicado: (2016)

Caspase-2 and p75 neurotrophin receptor (p75NTR) are involved in the regulation of SREBP and lipid genes in hepatocyte cells
por: Pham, Dan Duc, et al.
Publicado: (2019)

Targeted Nanotherapeutics Using LACTB Gene Therapy Against Melanoma
por: Liu, Jinlu, et al.
Publicado: (2021)

LACTB suppresses carcinogenesis in lung cancer and regulates the EMT pathway
por: Xu, Yihui, et al.
Publicado: (2022)

Disruption of NCOA2 by recurrent fusion with LACTB2 in colorectal cancer
por: Yu, J, et al.
Publicado: (2016)

MicroRNA-1276 Promotes Colon Cancer Cell Proliferation by Negatively Regulating LACTB
por: Wang, Chunxiao, et al.
Publicado: (2020)

LACTB exerts tumor suppressor properties in epithelial ovarian cancer through regulation of Slug
por: Cutano, Valentina, et al.
Publicado: (2022)

LACTB mRNA expression is increased in pancreatic adenocarcinoma and high expression indicates a poor prognosis
por: Xie, Jian, et al.
Publicado: (2021)

LACTB induces cancer cell death through the activation of the intrinsic caspase-independent pathway in breast cancer
por: Gonzalez-Morena, Juan M., et al.
Publicado: (2022)

Recent Insights into the Role of Unfolded Protein Response in ER Stress in Health and Disease
por: Lindholm, Dan, et al.
Publicado: (2017)

LACTB and LC3 could serve as potential biomarkers of gastric cancer to neoadjuvant chemotherapy with oxaliplatin plus S-1
por: Yang, Fang, et al.
Publicado: (2021)

Unveiling the polarity of actin filaments by cryo-electron tomography
por: Martins, Bruno, et al.
Publicado: (2021)

The metabolic enzyme CTP synthase forms cytoskeletal filaments
por: Ingerson-Mahar, Michael, et al.
Publicado: (2010)

Dynamic Interaction of USP14 with the Chaperone HSC70 Mediates Crosstalk between the Proteasome, ER Signaling, and Autophagy
por: Srinivasan, Vignesh, et al.
Publicado: (2019)

Upregulation of miR‐374a promotes tumor metastasis and progression by downregulating LACTB and predicts unfavorable prognosis in breast cancer
por: Zhang, Jun, et al.
Publicado: (2018)

A RAD51–ADP double filament structure unveils the mechanism of filament dynamics in homologous recombination
por: Luo, Shih-Chi, et al.
Publicado: (2023)

Identification and characterization of novel filament-forming proteins in cyanobacteria
por: Springstein, Benjamin L., et al.
Publicado: (2020)

Structures, functions, and mechanisms of filament forming enzymes: a renaissance of enzyme filamentation
por: Park, Chad K., et al.
Publicado: (2019)

Fibroblast growth factor-21 enhances mitochondrial functions and increases the activity of PGC-1α in human dopaminergic neurons via Sirtuin-1
por: Mäkelä, Johanna, et al.
Publicado: (2014)

PGC-1α Signaling Increases GABA(A) Receptor Subunit α2 Expression, GABAergic Neurotransmission and Anxiety-Like Behavior in Mice
por: Vanaveski, Taavi, et al.
Publicado: (2021)

Identification of novel filament-forming proteins in Saccharomyces cerevisiae and Drosophila melanogaster
por: Noree, Chalongrat, et al.
Publicado: (2010)

The plant nuclear lamina proteins NMCP1 and NMCP2 form a filamentous network with lateral filament associations
por: Masuda, Kiyoshi, et al.
Publicado: (2021)

Rootletin forms centriole-associated filaments and functions in centrosome cohesion
por: Bahe, Susanne, et al.
Publicado: (2005)

Controlling RNA self-assembly to form filaments
por: Nasalean, Lorena, et al.
Publicado: (2006)

The filament-forming protein Pil1 assembles linear eisosomes in fission yeast
por: Kabeche, Ruth, et al.
Publicado: (2011)

Myosin-Induced Gliding Patterns at Varied [MgATP] Unveil a Dynamic Actin Filament
por: Bengtsson, Elina, et al.
Publicado: (2016)

LACTB Regulates PIK3R3 to Promote Autophagy and Inhibit EMT and Proliferation Through the PI3K/AKT/mTOR Signaling Pathway in Colorectal Cancer
por: Xu, Wei, et al.
Publicado: (2020)

Proteomic and functional analyses in disease models reveal CLN5 protein involvement in mitochondrial dysfunction
por: Doccini, Stefano, et al.
Publicado: (2020)

Unveiling the Metabolic Effects of Glycomacropeptide
por: Pena, Maria João, et al.
Publicado: (2021)

Lysosomal Proteomics Links Disturbances in Lipid Homeostasis and Sphingolipid Metabolism to CLN5 Disease
por: Doccini, Stefano, et al.
Publicado: (2022)

Vimentin intermediate filaments and filamentous actin form unexpected interpenetrating networks that redefine the cell cortex
por: Wu, Huayin, et al.
Publicado: (2022)

Evolution of a family of metazoan active-site-serine enzymes from penicillin-binding proteins: a novel facet of the bacterial legacy
por: Peitsaro, Nina, et al.
Publicado: (2008)

Site-specific glycosylation regulates the form and function of the intermediate filament cytoskeleton
por: Tarbet, Heather J, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_nd7ola6tg696fn481q8mo674fi