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Pleiotropic Effects of IGF1 on the Oocyte
A woman’s endocrine system plays a crucial role in orchestrating cellular interactions throughout her life. The growth hormone (GH) and insulin-like growth factor (IGF) system appears to impact crucial reproductive events and cell types of the ovary, such as granulosa cells, theca cells, and oocytes...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9140015/ https://www.ncbi.nlm.nih.gov/pubmed/35626647 http://dx.doi.org/10.3390/cells11101610 |
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author | Kordowitzki, Paweł Krajnik, Kornelia Skowronska, Agnieszka Skowronski, Mariusz T. |
author_facet | Kordowitzki, Paweł Krajnik, Kornelia Skowronska, Agnieszka Skowronski, Mariusz T. |
author_sort | Kordowitzki, Paweł |
collection | PubMed |
description | A woman’s endocrine system plays a crucial role in orchestrating cellular interactions throughout her life. The growth hormone (GH) and insulin-like growth factor (IGF) system appears to impact crucial reproductive events and cell types of the ovary, such as granulosa cells, theca cells, and oocytes. Further, IGF1 is a cornerstone during embryonic development and influences predominantly developing and pre-antral follicles. In this commentary, we will emphasize the pleiotropic effects of IGF1 on physiological processes inside the egg. Herein, we will provide a brief overview on IGF1 related cell signal transduction pathways during the maturation and aging of oocytes. We aim to elucidate from a molecular and biochemical point of view if IGF1 in women with metabolic imbalances such as obesity or diabetes could be used in clinics as a novel, reliable estimator for the developmental competence of an oocyte. |
format | Online Article Text |
id | pubmed-9140015 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91400152022-05-28 Pleiotropic Effects of IGF1 on the Oocyte Kordowitzki, Paweł Krajnik, Kornelia Skowronska, Agnieszka Skowronski, Mariusz T. Cells Commentary A woman’s endocrine system plays a crucial role in orchestrating cellular interactions throughout her life. The growth hormone (GH) and insulin-like growth factor (IGF) system appears to impact crucial reproductive events and cell types of the ovary, such as granulosa cells, theca cells, and oocytes. Further, IGF1 is a cornerstone during embryonic development and influences predominantly developing and pre-antral follicles. In this commentary, we will emphasize the pleiotropic effects of IGF1 on physiological processes inside the egg. Herein, we will provide a brief overview on IGF1 related cell signal transduction pathways during the maturation and aging of oocytes. We aim to elucidate from a molecular and biochemical point of view if IGF1 in women with metabolic imbalances such as obesity or diabetes could be used in clinics as a novel, reliable estimator for the developmental competence of an oocyte. MDPI 2022-05-11 /pmc/articles/PMC9140015/ /pubmed/35626647 http://dx.doi.org/10.3390/cells11101610 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Commentary Kordowitzki, Paweł Krajnik, Kornelia Skowronska, Agnieszka Skowronski, Mariusz T. Pleiotropic Effects of IGF1 on the Oocyte |
title | Pleiotropic Effects of IGF1 on the Oocyte |
title_full | Pleiotropic Effects of IGF1 on the Oocyte |
title_fullStr | Pleiotropic Effects of IGF1 on the Oocyte |
title_full_unstemmed | Pleiotropic Effects of IGF1 on the Oocyte |
title_short | Pleiotropic Effects of IGF1 on the Oocyte |
title_sort | pleiotropic effects of igf1 on the oocyte |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9140015/ https://www.ncbi.nlm.nih.gov/pubmed/35626647 http://dx.doi.org/10.3390/cells11101610 |
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