Pyroptosis and Its Role in SARS-CoV-2 Infection

The pore-forming inflammatory cell death pathway, pyroptosis, was first described in the early 1990s and its role in health and disease has been intensively studied since. The effector molecule GSDMD is cleaved by activated caspases, mainly Caspase 1 or 11 (Caspase 4/5 in humans), downstream of infl...

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Autores principales: Bittner, Zsofia Agnes, Schrader, Markus, George, Shilpa Elizabeth, Amann, Ralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9140030/
https://www.ncbi.nlm.nih.gov/pubmed/35626754
http://dx.doi.org/10.3390/cells11101717
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author Bittner, Zsofia Agnes
Schrader, Markus
George, Shilpa Elizabeth
Amann, Ralf
author_facet Bittner, Zsofia Agnes
Schrader, Markus
George, Shilpa Elizabeth
Amann, Ralf
author_sort Bittner, Zsofia Agnes
collection PubMed
description The pore-forming inflammatory cell death pathway, pyroptosis, was first described in the early 1990s and its role in health and disease has been intensively studied since. The effector molecule GSDMD is cleaved by activated caspases, mainly Caspase 1 or 11 (Caspase 4/5 in humans), downstream of inflammasome formation. In this review, we describe the molecular events related to GSDMD-mediated pore formation. Furthermore, we summarize the so far elucidated ways of SARS-CoV-2 induced NLRP3 inflammasome formation leading to pyroptosis, which strongly contributes to COVID-19 pathology. We also explore the potential of NLRP3 and GSDMD inhibitors as therapeutics to counter excessive inflammation.
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spelling pubmed-91400302022-05-28 Pyroptosis and Its Role in SARS-CoV-2 Infection Bittner, Zsofia Agnes Schrader, Markus George, Shilpa Elizabeth Amann, Ralf Cells Review The pore-forming inflammatory cell death pathway, pyroptosis, was first described in the early 1990s and its role in health and disease has been intensively studied since. The effector molecule GSDMD is cleaved by activated caspases, mainly Caspase 1 or 11 (Caspase 4/5 in humans), downstream of inflammasome formation. In this review, we describe the molecular events related to GSDMD-mediated pore formation. Furthermore, we summarize the so far elucidated ways of SARS-CoV-2 induced NLRP3 inflammasome formation leading to pyroptosis, which strongly contributes to COVID-19 pathology. We also explore the potential of NLRP3 and GSDMD inhibitors as therapeutics to counter excessive inflammation. MDPI 2022-05-23 /pmc/articles/PMC9140030/ /pubmed/35626754 http://dx.doi.org/10.3390/cells11101717 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bittner, Zsofia Agnes
Schrader, Markus
George, Shilpa Elizabeth
Amann, Ralf
Pyroptosis and Its Role in SARS-CoV-2 Infection
title Pyroptosis and Its Role in SARS-CoV-2 Infection
title_full Pyroptosis and Its Role in SARS-CoV-2 Infection
title_fullStr Pyroptosis and Its Role in SARS-CoV-2 Infection
title_full_unstemmed Pyroptosis and Its Role in SARS-CoV-2 Infection
title_short Pyroptosis and Its Role in SARS-CoV-2 Infection
title_sort pyroptosis and its role in sars-cov-2 infection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9140030/
https://www.ncbi.nlm.nih.gov/pubmed/35626754
http://dx.doi.org/10.3390/cells11101717
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