Diphenyleneiodonium Triggers Cell Death of Acute Myeloid Leukemia Cells by Blocking the Mitochondrial Respiratory Chain, and Synergizes with Cytarabine

SIMPLE SUMMARY: Acute myeloid leukemia (AML) is an aggressive heterogeneous cancer of the blood, of which 70% of cases develop relapse. Relapse is mainly due to chemoresistant leukemic cells (LCs) that are characterized by high mitochondrial oxidative phosphorylation (OxPhos) status, i.e., cells tha...

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Detalles Bibliográficos
Autores principales: Dakik, Hassan, El Dor, Maya, Bourgeais, Jérôme, Kouzi, Farah, Herault, Olivier, Gouilleux, Fabrice, Zibara, Kazem, Mazurier, Frédéric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9140039/
https://www.ncbi.nlm.nih.gov/pubmed/35626090
http://dx.doi.org/10.3390/cancers14102485

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9140039/
https://www.ncbi.nlm.nih.gov/pubmed/35626090
http://dx.doi.org/10.3390/cancers14102485

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