Cargando…

Diphenyleneiodonium Triggers Cell Death of Acute Myeloid Leukemia Cells by Blocking the Mitochondrial Respiratory Chain, and Synergizes with Cytarabine

SIMPLE SUMMARY: Acute myeloid leukemia (AML) is an aggressive heterogeneous cancer of the blood, of which 70% of cases develop relapse. Relapse is mainly due to chemoresistant leukemic cells (LCs) that are characterized by high mitochondrial oxidative phosphorylation (OxPhos) status, i.e., cells tha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dakik, Hassan, El Dor, Maya, Bourgeais, Jérôme, Kouzi, Farah, Herault, Olivier, Gouilleux, Fabrice, Zibara, Kazem, Mazurier, Frédéric
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9140039/ https://www.ncbi.nlm.nih.gov/pubmed/35626090 http://dx.doi.org/10.3390/cancers14102485

Ejemplares similares

Characterization of NADPH Oxidase Expression and Activity in Acute Myeloid Leukemia Cell Lines: A Correlation with the Differentiation Status
por: Dakik, Hassan, et al.
Publicado: (2021)

VAS3947 Induces UPR-Mediated Apoptosis through Cysteine Thiol Alkylation in AML Cell Lines
por: El Dor, Maya, et al.
Publicado: (2020)

Disruption of gap junctions attenuates acute myeloid leukemia chemoresistance induced by bone marrow mesenchymal stromal cells
por: Kouzi, Farah, et al.
Publicado: (2019)

Correction: Disruption of gap junctions attenuates acute myeloid leukemia chemoresistance induced by bone marrow mesenchymal stromal cells
por: Kouzi, Farah, et al.
Publicado: (2019)

Acriflavine targets oncogenic STAT5 signaling in myeloid leukemia cells
por: Hallal, Rawan, et al.
Publicado: (2020)

Oncogenic STAT5 signaling promotes oxidative stress in chronic myeloid leukemia cells by repressing antioxidant defenses
por: Bourgeais, Jerome, et al.
Publicado: (2016)

Cyclin D1 unbalances the redox status controlling cell adhesion, migration, and drug resistance in myeloma cells
por: Bustany, Sophie, et al.
Publicado: (2016)

Oxidative metabolism in cancer: A STAT affair?
por: Bourgeais, Jérome, et al.
Publicado: (2013)

Cyclin D1 targets hexokinase 2 to control aerobic glycolysis in myeloma cells
por: Caillot, M., et al.
Publicado: (2020)

Dendrogenin A Synergizes with Cytarabine to Kill Acute Myeloid Leukemia Cells In Vitro and In Vivo
por: Serhan, Nizar, et al.
Publicado: (2020)

A Novel Inhibitor of STAT5 Signaling Overcomes Chemotherapy Resistance in Myeloid Leukemia Cells
por: Brachet-Botineau, Marie, et al.
Publicado: (2019)

STAT5A/5B-specific expansion and transformation of hematopoietic stem cells
por: Ghanem, S, et al.
Publicado: (2017)

Adherence of Trichomonas vaginalis to SiHa Cells is Inhibited by Diphenyleneiodonium
por: Kim, Yeeun, et al.
Publicado: (2020)

Potent inhibition of nitroglycerin bioactivation by diphenyleneiodonium (DIP)
por: Neubauer, Regina, et al.
Publicado: (2013)

Diphenyleneiodonium, an inhibitor of NOXes and DUOXes, is also an iodide-specific transporter()
por: Massart, C., et al.
Publicado: (2013)

Diphenyleneiodonium chloride (DPIC) displays broad-spectrum bactericidal activity
por: Pandey, Manitosh, et al.
Publicado: (2017)

Efficacy of Diphenyleneiodonium Chloride (DPIC) Against Diverse Plant Pathogens
por: Jung, Boknam, et al.
Publicado: (2019)

Targeting Reactive Oxygen Species Metabolism to Induce Myeloma Cell Death
por: Caillot, Mélody, et al.
Publicado: (2021)

PB2157: TREATMENT WITH DIPHENYLENEIODONIUM CHLORIDE EXHIBITS CELL GROWTH INHIBITORY EFFECTS ON AGGRESSIVE LYMPHOMA CELLS
por: Haingartner, S., et al.
Publicado: (2022)

In Vitro Activity of Diphenyleneiodonium toward Multidrug-Resistant Helicobacter pylori Strains
por: Chung, Jun-Won, et al.
Publicado: (2017)

ROS Overproduction Sensitises Myeloma Cells to Bortezomib-Induced Apoptosis and Alleviates Tumour Microenvironment-Mediated Cell Resistance
por: Caillot, Mélody, et al.
Publicado: (2020)

Diphenyleneiodonium Inhibits Apoptotic Cell Death of Gastric Epithelial Cells Infected with Helicobacter pylori in a Korean Isolate
por: Cho, Soon Ok, et al.
Publicado: (2015)

Cytotoxic Marine Alkaloid 3,10-Dibromofascaplysin Induces Apoptosis and Synergizes with Cytarabine Resulting in Leukemia Cell Death
por: Spirin, Pavel, et al.
Publicado: (2021)

Inhibition of NADPH Oxidases Activity by Diphenyleneiodonium Chloride as a Mechanism of Senescence Induction in Human Cancer Cells
por: Piszczatowska, Katarzyna, et al.
Publicado: (2020)

Author Correction: Diphenyleneiodonium chloride (DPIC) displays broad-spectrum bactericidal activity
por: Pandey, Manitosh, et al.
Publicado: (2018)

Phase I study of alvocidib plus cytarabine/mitoxantrone or cytarabine/daunorubicin for acute myeloid leukemia in Japan
por: Ikezoe, Takayuki, et al.
Publicado: (2022)

Inhibition of Mnk enhances apoptotic activity of cytarabine in acute myeloid leukemia cells
por: Li, Peng, et al.
Publicado: (2016)

Pannexin1 Is Associated with Enhanced Epithelial-To-Mesenchymal Transition in Human Patient Breast Cancer Tissues and in Breast Cancer Cell Lines
por: Jalaleddine, Nour, et al.
Publicado: (2019)

Venetoclax and alvocidib are both cytotoxic to acute myeloid leukemia cells resistant to cytarabine and clofarabine
por: Nishi, Rie, et al.
Publicado: (2020)

Radotinib enhances cytarabine (Ara-C)-induced acute myeloid leukemia cell death
por: Heo, Sook-Kyoung, et al.
Publicado: (2020)

Inhibition of Autophagy Does Not Re-Sensitize Acute Myeloid Leukemia Cells Resistant to Cytarabine
por: Visser, Nienke, et al.
Publicado: (2021)

EIF4A inhibition targets bioenergetic homeostasis in AML MOLM-14 cells in vitro and in vivo and synergizes with cytarabine and venetoclax
por: Fooks, Katie, et al.
Publicado: (2022)

Optimization of cytarabine (ARA-C) therapy for acute myeloid leukemia
por: Momparler, Richard L
Publicado: (2013)

Daunorubicin/Cytarabine Liposome: A Review in Acute Myeloid Leukaemia
por: Blair, Hannah A.
Publicado: (2018)

Mathematical models for cytarabine-derived myelosuppression in acute myeloid leukaemia
por: Jost, Felix, et al.
Publicado: (2019)

The NADPH Oxidase Inhibitors Apocynin and Diphenyleneiodonium Protect Rats from LPS-Induced Pulmonary Inflammation
por: Kouki, Ahmed, et al.
Publicado: (2023)

Analysis of the Neuroproteome Associated With Cell Therapy After Intranigral Grafting in a Mouse Model of Parkinson Disease
por: Dakik, Hassan, et al.
Publicado: (2021)

Retrospective Comparison of Fludarabine in Combination With Intermediate-Dose Cytarabine Versus High-Dose Cytarabine As Consolidation Therapies for Acute Myeloid Leukemia
por: Zhang, Wenjun, et al.
Publicado: (2014)

Conditioned Medium from Cells Overexpressing TDP-43 Alters the Metabolome of Recipient Cells
por: Hergesheimer, Rudolf, et al.
Publicado: (2020)

Disseminated Langerhans cell histiocytosis associated with acute myeloid leukaemia: complete remission with daunorubicin and cytarabine
por: Hwang, Yu-Yan, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_oek8cr4qiflv04cs6n82tkl0ed