Mutation of PTPN11 (Encoding SHP-2) Promotes MEK Activation and Malignant Progression in Neurofibromin-Deficient Cells in a Manner Sensitive to BRAP Mutation

SIMPLE SUMMARY: Germline mutations of NF1 cause neurofibromatosis type 1 (NF1), which is characterized by multiple benign peripheral nerve sheath tumors known as neurofibromas. In some individuals with NF1, plexiform neurofibromas can give rise to malignant peripheral nerve sheath tumors. Here, we a...

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Detalles Bibliográficos
Autores principales: Harigai, Ritsuko, Sato, Ryo, Hirose, Chikako, Takenouchi, Toshiki, Kosaki, Kenjiro, Hirose, Takanori, Saya, Hideyuki, Arima, Yoshimi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9140047/
https://www.ncbi.nlm.nih.gov/pubmed/35625983
http://dx.doi.org/10.3390/cancers14102377

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