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Cerebral Venous Thrombosis after SARS-CoV-2 Infection and Pfizer-BioNTech Vaccination against COVID-19

In the last 3 years, COVID-19 pandemic has produced great impacts on global population in terms of health and social costs. Pneumonia represents only one of several pathologies associated to COVID-19 disease. Among these, the cerebral venous thrombosis (CVT), constitutes an important cause of stroke...

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Autores principales: Nicolardi, Martina, Urso, Daniele, Luceri, Silvia, Logroscino, Giancarlo, De Blasi, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9140082/
https://www.ncbi.nlm.nih.gov/pubmed/35626407
http://dx.doi.org/10.3390/diagnostics12051253
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author Nicolardi, Martina
Urso, Daniele
Luceri, Silvia
Logroscino, Giancarlo
De Blasi, Roberto
author_facet Nicolardi, Martina
Urso, Daniele
Luceri, Silvia
Logroscino, Giancarlo
De Blasi, Roberto
author_sort Nicolardi, Martina
collection PubMed
description In the last 3 years, COVID-19 pandemic has produced great impacts on global population in terms of health and social costs. Pneumonia represents only one of several pathologies associated to COVID-19 disease. Among these, the cerebral venous thrombosis (CVT), constitutes an important cause of stroke. Here, we report a case of CVT diagnosed approximately 2 weeks after first dose of Pfizer-BioNTech vaccination, in a patient affected by COVID-19 few months earlier. He presented with headache and severe asthenia. The laboratory tests put in evidence thrombocytopenia and D-dimer elevation. A brain magnetic resonance imaging (MRI) and a computed tomography (CT) demonstrated hemorrhagic and ischemic phenomena on the right ventral thalamic nuclei, left thalamus, hippocampal and parahippocampal regions and the splenium of the corpus callosum. The study revealed a poorly opacified vein of Galeno and straight sinus. Heparin administration improved his clinical status; platelets values also arose over time.
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spelling pubmed-91400822022-05-28 Cerebral Venous Thrombosis after SARS-CoV-2 Infection and Pfizer-BioNTech Vaccination against COVID-19 Nicolardi, Martina Urso, Daniele Luceri, Silvia Logroscino, Giancarlo De Blasi, Roberto Diagnostics (Basel) Interesting Images In the last 3 years, COVID-19 pandemic has produced great impacts on global population in terms of health and social costs. Pneumonia represents only one of several pathologies associated to COVID-19 disease. Among these, the cerebral venous thrombosis (CVT), constitutes an important cause of stroke. Here, we report a case of CVT diagnosed approximately 2 weeks after first dose of Pfizer-BioNTech vaccination, in a patient affected by COVID-19 few months earlier. He presented with headache and severe asthenia. The laboratory tests put in evidence thrombocytopenia and D-dimer elevation. A brain magnetic resonance imaging (MRI) and a computed tomography (CT) demonstrated hemorrhagic and ischemic phenomena on the right ventral thalamic nuclei, left thalamus, hippocampal and parahippocampal regions and the splenium of the corpus callosum. The study revealed a poorly opacified vein of Galeno and straight sinus. Heparin administration improved his clinical status; platelets values also arose over time. MDPI 2022-05-18 /pmc/articles/PMC9140082/ /pubmed/35626407 http://dx.doi.org/10.3390/diagnostics12051253 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Interesting Images
Nicolardi, Martina
Urso, Daniele
Luceri, Silvia
Logroscino, Giancarlo
De Blasi, Roberto
Cerebral Venous Thrombosis after SARS-CoV-2 Infection and Pfizer-BioNTech Vaccination against COVID-19
title Cerebral Venous Thrombosis after SARS-CoV-2 Infection and Pfizer-BioNTech Vaccination against COVID-19
title_full Cerebral Venous Thrombosis after SARS-CoV-2 Infection and Pfizer-BioNTech Vaccination against COVID-19
title_fullStr Cerebral Venous Thrombosis after SARS-CoV-2 Infection and Pfizer-BioNTech Vaccination against COVID-19
title_full_unstemmed Cerebral Venous Thrombosis after SARS-CoV-2 Infection and Pfizer-BioNTech Vaccination against COVID-19
title_short Cerebral Venous Thrombosis after SARS-CoV-2 Infection and Pfizer-BioNTech Vaccination against COVID-19
title_sort cerebral venous thrombosis after sars-cov-2 infection and pfizer-biontech vaccination against covid-19
topic Interesting Images
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9140082/
https://www.ncbi.nlm.nih.gov/pubmed/35626407
http://dx.doi.org/10.3390/diagnostics12051253
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