Cargando…
The Science Behind G Protein-Coupled Receptors (GPCRs) and Their Accurate Visual Representation in Scientific Research
G Protein-Coupled Receptors (GPCRs) are transmembrane (TM) proteins that span the cell membrane seven times, and contain intracellular and extracellular domains, comprised of connecting loops, as well as terminal extension sequences. GPCRs bind ligands within their transmembrane and/or extracellular...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
University of Illinois at Chicago Library
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9140105/ https://www.ncbi.nlm.nih.gov/pubmed/36405408 http://dx.doi.org/10.5210/jbc.v41i1.7309 |
_version_ | 1784715017692643328 |
---|---|
author | Sojka, Amy C. Brennan, Kevin M. Maizels, Evelyn T. Young, Christine D. |
author_facet | Sojka, Amy C. Brennan, Kevin M. Maizels, Evelyn T. Young, Christine D. |
author_sort | Sojka, Amy C. |
collection | PubMed |
description | G Protein-Coupled Receptors (GPCRs) are transmembrane (TM) proteins that span the cell membrane seven times, and contain intracellular and extracellular domains, comprised of connecting loops, as well as terminal extension sequences. GPCRs bind ligands within their transmembrane and/or extracellular domains. Ligand binding elicits conformational changes that initiate downstream intracellular signaling events through arrestins and G proteins. GPCRs play central roles in many physiological processes, from sensory to neurological, cardiovascular, endocrine, and reproductive functions. This paper strives to provide an entry point to current GPCR science, and to identify visual approaches to communicate select aspects of GPCR structure and function with clarity and accuracy. The overall GPCR structure, primary sequence and the implications of sequence for membrane topology, ligand binding and helical rearrangements accompanying activation are considered and discussed in the context of visualization strategies, including two-dimensional topological diagrams, three-dimensional representations, and common errors that arise from these representations. |
format | Online Article Text |
id | pubmed-9140105 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | University of Illinois at Chicago Library |
record_format | MEDLINE/PubMed |
spelling | pubmed-91401052022-11-18 The Science Behind G Protein-Coupled Receptors (GPCRs) and Their Accurate Visual Representation in Scientific Research Sojka, Amy C. Brennan, Kevin M. Maizels, Evelyn T. Young, Christine D. J Biocommun Research Article G Protein-Coupled Receptors (GPCRs) are transmembrane (TM) proteins that span the cell membrane seven times, and contain intracellular and extracellular domains, comprised of connecting loops, as well as terminal extension sequences. GPCRs bind ligands within their transmembrane and/or extracellular domains. Ligand binding elicits conformational changes that initiate downstream intracellular signaling events through arrestins and G proteins. GPCRs play central roles in many physiological processes, from sensory to neurological, cardiovascular, endocrine, and reproductive functions. This paper strives to provide an entry point to current GPCR science, and to identify visual approaches to communicate select aspects of GPCR structure and function with clarity and accuracy. The overall GPCR structure, primary sequence and the implications of sequence for membrane topology, ligand binding and helical rearrangements accompanying activation are considered and discussed in the context of visualization strategies, including two-dimensional topological diagrams, three-dimensional representations, and common errors that arise from these representations. University of Illinois at Chicago Library 2017-05-04 /pmc/articles/PMC9140105/ /pubmed/36405408 http://dx.doi.org/10.5210/jbc.v41i1.7309 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/The authors have chosen to license this content under a Creative Commons Attribution, NonCommercial, NoDerivatives License 4.0 International License. |
spellingShingle | Research Article Sojka, Amy C. Brennan, Kevin M. Maizels, Evelyn T. Young, Christine D. The Science Behind G Protein-Coupled Receptors (GPCRs) and Their Accurate Visual Representation in Scientific Research |
title | The Science Behind G Protein-Coupled Receptors (GPCRs) and Their Accurate Visual Representation in Scientific Research |
title_full | The Science Behind G Protein-Coupled Receptors (GPCRs) and Their Accurate Visual Representation in Scientific Research |
title_fullStr | The Science Behind G Protein-Coupled Receptors (GPCRs) and Their Accurate Visual Representation in Scientific Research |
title_full_unstemmed | The Science Behind G Protein-Coupled Receptors (GPCRs) and Their Accurate Visual Representation in Scientific Research |
title_short | The Science Behind G Protein-Coupled Receptors (GPCRs) and Their Accurate Visual Representation in Scientific Research |
title_sort | science behind g protein-coupled receptors (gpcrs) and their accurate visual representation in scientific research |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9140105/ https://www.ncbi.nlm.nih.gov/pubmed/36405408 http://dx.doi.org/10.5210/jbc.v41i1.7309 |
work_keys_str_mv | AT sojkaamyc thesciencebehindgproteincoupledreceptorsgpcrsandtheiraccuratevisualrepresentationinscientificresearch AT brennankevinm thesciencebehindgproteincoupledreceptorsgpcrsandtheiraccuratevisualrepresentationinscientificresearch AT maizelsevelynt thesciencebehindgproteincoupledreceptorsgpcrsandtheiraccuratevisualrepresentationinscientificresearch AT youngchristined thesciencebehindgproteincoupledreceptorsgpcrsandtheiraccuratevisualrepresentationinscientificresearch AT sojkaamyc sciencebehindgproteincoupledreceptorsgpcrsandtheiraccuratevisualrepresentationinscientificresearch AT brennankevinm sciencebehindgproteincoupledreceptorsgpcrsandtheiraccuratevisualrepresentationinscientificresearch AT maizelsevelynt sciencebehindgproteincoupledreceptorsgpcrsandtheiraccuratevisualrepresentationinscientificresearch AT youngchristined sciencebehindgproteincoupledreceptorsgpcrsandtheiraccuratevisualrepresentationinscientificresearch |