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The Science Behind G Protein-Coupled Receptors (GPCRs) and Their Accurate Visual Representation in Scientific Research

G Protein-Coupled Receptors (GPCRs) are transmembrane (TM) proteins that span the cell membrane seven times, and contain intracellular and extracellular domains, comprised of connecting loops, as well as terminal extension sequences. GPCRs bind ligands within their transmembrane and/or extracellular...

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Detalles Bibliográficos
Autores principales: Sojka, Amy C., Brennan, Kevin M., Maizels, Evelyn T., Young, Christine D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: University of Illinois at Chicago Library 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9140105/
https://www.ncbi.nlm.nih.gov/pubmed/36405408
http://dx.doi.org/10.5210/jbc.v41i1.7309
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author Sojka, Amy C.
Brennan, Kevin M.
Maizels, Evelyn T.
Young, Christine D.
author_facet Sojka, Amy C.
Brennan, Kevin M.
Maizels, Evelyn T.
Young, Christine D.
author_sort Sojka, Amy C.
collection PubMed
description G Protein-Coupled Receptors (GPCRs) are transmembrane (TM) proteins that span the cell membrane seven times, and contain intracellular and extracellular domains, comprised of connecting loops, as well as terminal extension sequences. GPCRs bind ligands within their transmembrane and/or extracellular domains. Ligand binding elicits conformational changes that initiate downstream intracellular signaling events through arrestins and G proteins. GPCRs play central roles in many physiological processes, from sensory to neurological, cardiovascular, endocrine, and reproductive functions. This paper strives to provide an entry point to current GPCR science, and to identify visual approaches to communicate select aspects of GPCR structure and function with clarity and accuracy. The overall GPCR structure, primary sequence and the implications of sequence for membrane topology, ligand binding and helical rearrangements accompanying activation are considered and discussed in the context of visualization strategies, including two-dimensional topological diagrams, three-dimensional representations, and common errors that arise from these representations.
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spelling pubmed-91401052022-11-18 The Science Behind G Protein-Coupled Receptors (GPCRs) and Their Accurate Visual Representation in Scientific Research Sojka, Amy C. Brennan, Kevin M. Maizels, Evelyn T. Young, Christine D. J Biocommun Research Article G Protein-Coupled Receptors (GPCRs) are transmembrane (TM) proteins that span the cell membrane seven times, and contain intracellular and extracellular domains, comprised of connecting loops, as well as terminal extension sequences. GPCRs bind ligands within their transmembrane and/or extracellular domains. Ligand binding elicits conformational changes that initiate downstream intracellular signaling events through arrestins and G proteins. GPCRs play central roles in many physiological processes, from sensory to neurological, cardiovascular, endocrine, and reproductive functions. This paper strives to provide an entry point to current GPCR science, and to identify visual approaches to communicate select aspects of GPCR structure and function with clarity and accuracy. The overall GPCR structure, primary sequence and the implications of sequence for membrane topology, ligand binding and helical rearrangements accompanying activation are considered and discussed in the context of visualization strategies, including two-dimensional topological diagrams, three-dimensional representations, and common errors that arise from these representations. University of Illinois at Chicago Library 2017-05-04 /pmc/articles/PMC9140105/ /pubmed/36405408 http://dx.doi.org/10.5210/jbc.v41i1.7309 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/The authors have chosen to license this content under a Creative Commons Attribution, NonCommercial, NoDerivatives License 4.0 International License.
spellingShingle Research Article
Sojka, Amy C.
Brennan, Kevin M.
Maizels, Evelyn T.
Young, Christine D.
The Science Behind G Protein-Coupled Receptors (GPCRs) and Their Accurate Visual Representation in Scientific Research
title The Science Behind G Protein-Coupled Receptors (GPCRs) and Their Accurate Visual Representation in Scientific Research
title_full The Science Behind G Protein-Coupled Receptors (GPCRs) and Their Accurate Visual Representation in Scientific Research
title_fullStr The Science Behind G Protein-Coupled Receptors (GPCRs) and Their Accurate Visual Representation in Scientific Research
title_full_unstemmed The Science Behind G Protein-Coupled Receptors (GPCRs) and Their Accurate Visual Representation in Scientific Research
title_short The Science Behind G Protein-Coupled Receptors (GPCRs) and Their Accurate Visual Representation in Scientific Research
title_sort science behind g protein-coupled receptors (gpcrs) and their accurate visual representation in scientific research
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9140105/
https://www.ncbi.nlm.nih.gov/pubmed/36405408
http://dx.doi.org/10.5210/jbc.v41i1.7309
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