Endocrine Therapy-Resistant Breast Cancer Cells Are More Sensitive to Ceramide Kinase Inhibition and Elevated Ceramide Levels Than Therapy-Sensitive Breast Cancer Cells

SIMPLE SUMMARY: Endocrine therapy (ET) resistance is a major problem in estrogen receptor-positive breast cancer patients. Since there have been few lipidomic studies in ET resistance and sphingolipids are heavily implicated in multidrug-resistant and chemotherapy-resistant cancers, we aimed to inve...

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Detalles Bibliográficos
Autores principales: Pal, Purab, Millner, Alec, Semina, Svetlana E., Huggins, Rosemary J., Running, Logan, Aga, Diana S., Tonetti, Debra A., Schiff, Rachel, Greene, Geoffrey L., Atilla-Gokcumen, G. Ekin, Frasor, Jonna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9140186/
https://www.ncbi.nlm.nih.gov/pubmed/35625985
http://dx.doi.org/10.3390/cancers14102380

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