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Therapy Strategies for Children Suffering from Inflammatory Bowel Disease (IBD)—A Narrative Review
The incidence of inflammatory bowel disease (IBD) is increasing, and more children at a younger age are affected. The pathogenesis seems to be an interaction of microbial factors, a sensitivity of the immune system, and the intestinal barrier, leading to an inappropriate immune response. Not only ha...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9140197/ https://www.ncbi.nlm.nih.gov/pubmed/35626795 http://dx.doi.org/10.3390/children9050617 |
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author | Légeret, Corinne Furlano, Raoul Köhler, Henrik |
author_facet | Légeret, Corinne Furlano, Raoul Köhler, Henrik |
author_sort | Légeret, Corinne |
collection | PubMed |
description | The incidence of inflammatory bowel disease (IBD) is increasing, and more children at a younger age are affected. The pathogenesis seems to be an interaction of microbial factors, a sensitivity of the immune system, and the intestinal barrier, leading to an inappropriate immune response. Not only has the role of biological agents become more important in the last decade in the treatment of children and adolescents, but also new insights into the composition of the gastrointestinal microbiome and personal diet implications have increased our understanding of the disease and opened up potential therapeutic pathways. This narrative review provides an overview of current recommendations, therapeutic options, drug monitoring, and practical guidelines for paediatricians involved with paediatric IBD patients. Furthermore, the off-label use of potential helpful drugs in the treatment of these patients is discussed. |
format | Online Article Text |
id | pubmed-9140197 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91401972022-05-28 Therapy Strategies for Children Suffering from Inflammatory Bowel Disease (IBD)—A Narrative Review Légeret, Corinne Furlano, Raoul Köhler, Henrik Children (Basel) Review The incidence of inflammatory bowel disease (IBD) is increasing, and more children at a younger age are affected. The pathogenesis seems to be an interaction of microbial factors, a sensitivity of the immune system, and the intestinal barrier, leading to an inappropriate immune response. Not only has the role of biological agents become more important in the last decade in the treatment of children and adolescents, but also new insights into the composition of the gastrointestinal microbiome and personal diet implications have increased our understanding of the disease and opened up potential therapeutic pathways. This narrative review provides an overview of current recommendations, therapeutic options, drug monitoring, and practical guidelines for paediatricians involved with paediatric IBD patients. Furthermore, the off-label use of potential helpful drugs in the treatment of these patients is discussed. MDPI 2022-04-26 /pmc/articles/PMC9140197/ /pubmed/35626795 http://dx.doi.org/10.3390/children9050617 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Légeret, Corinne Furlano, Raoul Köhler, Henrik Therapy Strategies for Children Suffering from Inflammatory Bowel Disease (IBD)—A Narrative Review |
title | Therapy Strategies for Children Suffering from Inflammatory Bowel Disease (IBD)—A Narrative Review |
title_full | Therapy Strategies for Children Suffering from Inflammatory Bowel Disease (IBD)—A Narrative Review |
title_fullStr | Therapy Strategies for Children Suffering from Inflammatory Bowel Disease (IBD)—A Narrative Review |
title_full_unstemmed | Therapy Strategies for Children Suffering from Inflammatory Bowel Disease (IBD)—A Narrative Review |
title_short | Therapy Strategies for Children Suffering from Inflammatory Bowel Disease (IBD)—A Narrative Review |
title_sort | therapy strategies for children suffering from inflammatory bowel disease (ibd)—a narrative review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9140197/ https://www.ncbi.nlm.nih.gov/pubmed/35626795 http://dx.doi.org/10.3390/children9050617 |
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