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Therapy Strategies for Children Suffering from Inflammatory Bowel Disease (IBD)—A Narrative Review

The incidence of inflammatory bowel disease (IBD) is increasing, and more children at a younger age are affected. The pathogenesis seems to be an interaction of microbial factors, a sensitivity of the immune system, and the intestinal barrier, leading to an inappropriate immune response. Not only ha...

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Detalles Bibliográficos
Autores principales: Légeret, Corinne, Furlano, Raoul, Köhler, Henrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9140197/
https://www.ncbi.nlm.nih.gov/pubmed/35626795
http://dx.doi.org/10.3390/children9050617
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author Légeret, Corinne
Furlano, Raoul
Köhler, Henrik
author_facet Légeret, Corinne
Furlano, Raoul
Köhler, Henrik
author_sort Légeret, Corinne
collection PubMed
description The incidence of inflammatory bowel disease (IBD) is increasing, and more children at a younger age are affected. The pathogenesis seems to be an interaction of microbial factors, a sensitivity of the immune system, and the intestinal barrier, leading to an inappropriate immune response. Not only has the role of biological agents become more important in the last decade in the treatment of children and adolescents, but also new insights into the composition of the gastrointestinal microbiome and personal diet implications have increased our understanding of the disease and opened up potential therapeutic pathways. This narrative review provides an overview of current recommendations, therapeutic options, drug monitoring, and practical guidelines for paediatricians involved with paediatric IBD patients. Furthermore, the off-label use of potential helpful drugs in the treatment of these patients is discussed.
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spelling pubmed-91401972022-05-28 Therapy Strategies for Children Suffering from Inflammatory Bowel Disease (IBD)—A Narrative Review Légeret, Corinne Furlano, Raoul Köhler, Henrik Children (Basel) Review The incidence of inflammatory bowel disease (IBD) is increasing, and more children at a younger age are affected. The pathogenesis seems to be an interaction of microbial factors, a sensitivity of the immune system, and the intestinal barrier, leading to an inappropriate immune response. Not only has the role of biological agents become more important in the last decade in the treatment of children and adolescents, but also new insights into the composition of the gastrointestinal microbiome and personal diet implications have increased our understanding of the disease and opened up potential therapeutic pathways. This narrative review provides an overview of current recommendations, therapeutic options, drug monitoring, and practical guidelines for paediatricians involved with paediatric IBD patients. Furthermore, the off-label use of potential helpful drugs in the treatment of these patients is discussed. MDPI 2022-04-26 /pmc/articles/PMC9140197/ /pubmed/35626795 http://dx.doi.org/10.3390/children9050617 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Légeret, Corinne
Furlano, Raoul
Köhler, Henrik
Therapy Strategies for Children Suffering from Inflammatory Bowel Disease (IBD)—A Narrative Review
title Therapy Strategies for Children Suffering from Inflammatory Bowel Disease (IBD)—A Narrative Review
title_full Therapy Strategies for Children Suffering from Inflammatory Bowel Disease (IBD)—A Narrative Review
title_fullStr Therapy Strategies for Children Suffering from Inflammatory Bowel Disease (IBD)—A Narrative Review
title_full_unstemmed Therapy Strategies for Children Suffering from Inflammatory Bowel Disease (IBD)—A Narrative Review
title_short Therapy Strategies for Children Suffering from Inflammatory Bowel Disease (IBD)—A Narrative Review
title_sort therapy strategies for children suffering from inflammatory bowel disease (ibd)—a narrative review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9140197/
https://www.ncbi.nlm.nih.gov/pubmed/35626795
http://dx.doi.org/10.3390/children9050617
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