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Recent Bioinformatic Progress to Identify Epigenetic Changes Associated to Transposable Elements

Transposable elements (TEs) are recognized for their great impact on the functioning and evolution of their host genomes. They are associated to various deleterious effects, which has led to the evolution of regulatory epigenetic mechanisms to control their activity. Despite these negative effects,...

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Autor principal: Lerat, Emmanuelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9140218/
https://www.ncbi.nlm.nih.gov/pubmed/35646069
http://dx.doi.org/10.3389/fgene.2022.891194
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author Lerat, Emmanuelle
author_facet Lerat, Emmanuelle
author_sort Lerat, Emmanuelle
collection PubMed
description Transposable elements (TEs) are recognized for their great impact on the functioning and evolution of their host genomes. They are associated to various deleterious effects, which has led to the evolution of regulatory epigenetic mechanisms to control their activity. Despite these negative effects, TEs are also important actors in the evolution of genomes by promoting genetic diversity and new regulatory elements. Consequently, it is important to study the epigenetic modifications associated to TEs especially at a locus-specific level to determine their individual influence on gene functioning. To this aim, this short review presents the current bioinformatic tools to achieve this task.
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spelling pubmed-91402182022-05-28 Recent Bioinformatic Progress to Identify Epigenetic Changes Associated to Transposable Elements Lerat, Emmanuelle Front Genet Genetics Transposable elements (TEs) are recognized for their great impact on the functioning and evolution of their host genomes. They are associated to various deleterious effects, which has led to the evolution of regulatory epigenetic mechanisms to control their activity. Despite these negative effects, TEs are also important actors in the evolution of genomes by promoting genetic diversity and new regulatory elements. Consequently, it is important to study the epigenetic modifications associated to TEs especially at a locus-specific level to determine their individual influence on gene functioning. To this aim, this short review presents the current bioinformatic tools to achieve this task. Frontiers Media S.A. 2022-05-13 /pmc/articles/PMC9140218/ /pubmed/35646069 http://dx.doi.org/10.3389/fgene.2022.891194 Text en Copyright © 2022 Lerat. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Lerat, Emmanuelle
Recent Bioinformatic Progress to Identify Epigenetic Changes Associated to Transposable Elements
title Recent Bioinformatic Progress to Identify Epigenetic Changes Associated to Transposable Elements
title_full Recent Bioinformatic Progress to Identify Epigenetic Changes Associated to Transposable Elements
title_fullStr Recent Bioinformatic Progress to Identify Epigenetic Changes Associated to Transposable Elements
title_full_unstemmed Recent Bioinformatic Progress to Identify Epigenetic Changes Associated to Transposable Elements
title_short Recent Bioinformatic Progress to Identify Epigenetic Changes Associated to Transposable Elements
title_sort recent bioinformatic progress to identify epigenetic changes associated to transposable elements
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9140218/
https://www.ncbi.nlm.nih.gov/pubmed/35646069
http://dx.doi.org/10.3389/fgene.2022.891194
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