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Recent Bioinformatic Progress to Identify Epigenetic Changes Associated to Transposable Elements
Transposable elements (TEs) are recognized for their great impact on the functioning and evolution of their host genomes. They are associated to various deleterious effects, which has led to the evolution of regulatory epigenetic mechanisms to control their activity. Despite these negative effects,...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9140218/ https://www.ncbi.nlm.nih.gov/pubmed/35646069 http://dx.doi.org/10.3389/fgene.2022.891194 |
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author | Lerat, Emmanuelle |
author_facet | Lerat, Emmanuelle |
author_sort | Lerat, Emmanuelle |
collection | PubMed |
description | Transposable elements (TEs) are recognized for their great impact on the functioning and evolution of their host genomes. They are associated to various deleterious effects, which has led to the evolution of regulatory epigenetic mechanisms to control their activity. Despite these negative effects, TEs are also important actors in the evolution of genomes by promoting genetic diversity and new regulatory elements. Consequently, it is important to study the epigenetic modifications associated to TEs especially at a locus-specific level to determine their individual influence on gene functioning. To this aim, this short review presents the current bioinformatic tools to achieve this task. |
format | Online Article Text |
id | pubmed-9140218 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91402182022-05-28 Recent Bioinformatic Progress to Identify Epigenetic Changes Associated to Transposable Elements Lerat, Emmanuelle Front Genet Genetics Transposable elements (TEs) are recognized for their great impact on the functioning and evolution of their host genomes. They are associated to various deleterious effects, which has led to the evolution of regulatory epigenetic mechanisms to control their activity. Despite these negative effects, TEs are also important actors in the evolution of genomes by promoting genetic diversity and new regulatory elements. Consequently, it is important to study the epigenetic modifications associated to TEs especially at a locus-specific level to determine their individual influence on gene functioning. To this aim, this short review presents the current bioinformatic tools to achieve this task. Frontiers Media S.A. 2022-05-13 /pmc/articles/PMC9140218/ /pubmed/35646069 http://dx.doi.org/10.3389/fgene.2022.891194 Text en Copyright © 2022 Lerat. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Lerat, Emmanuelle Recent Bioinformatic Progress to Identify Epigenetic Changes Associated to Transposable Elements |
title | Recent Bioinformatic Progress to Identify Epigenetic Changes Associated to Transposable Elements |
title_full | Recent Bioinformatic Progress to Identify Epigenetic Changes Associated to Transposable Elements |
title_fullStr | Recent Bioinformatic Progress to Identify Epigenetic Changes Associated to Transposable Elements |
title_full_unstemmed | Recent Bioinformatic Progress to Identify Epigenetic Changes Associated to Transposable Elements |
title_short | Recent Bioinformatic Progress to Identify Epigenetic Changes Associated to Transposable Elements |
title_sort | recent bioinformatic progress to identify epigenetic changes associated to transposable elements |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9140218/ https://www.ncbi.nlm.nih.gov/pubmed/35646069 http://dx.doi.org/10.3389/fgene.2022.891194 |
work_keys_str_mv | AT leratemmanuelle recentbioinformaticprogresstoidentifyepigeneticchangesassociatedtotransposableelements |