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The efficacy of oxidized regenerated cellulose (SurgiGuard(®)) in breast cancer patients who undergo total mastectomy with node surgery: A prospective randomized study in 94 patients

BACKGROUND: Seromas frequently develop in patients who undergo total mastectomy with node surgery. We aimed to prospectively explore whether use of oxidized regenerated cellulose (ORC, SurgiGuard(®)) affects seroma formation after total mastectomy with node surgery (sentinel lymph node biopsy (SLNB)...

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Autores principales: Nam, Kug Hyun, Lee, Joon-Hyop, Chung, Yoo Seung, Chun, Yong Soon, Park, Heung Kyu, Kim, Yun Yeong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9140258/
https://www.ncbi.nlm.nih.gov/pubmed/35622779
http://dx.doi.org/10.1371/journal.pone.0267694
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author Nam, Kug Hyun
Lee, Joon-Hyop
Chung, Yoo Seung
Chun, Yong Soon
Park, Heung Kyu
Kim, Yun Yeong
author_facet Nam, Kug Hyun
Lee, Joon-Hyop
Chung, Yoo Seung
Chun, Yong Soon
Park, Heung Kyu
Kim, Yun Yeong
author_sort Nam, Kug Hyun
collection PubMed
description BACKGROUND: Seromas frequently develop in patients who undergo total mastectomy with node surgery. We aimed to prospectively explore whether use of oxidized regenerated cellulose (ORC, SurgiGuard(®)) affects seroma formation after total mastectomy with node surgery (sentinel lymph node biopsy (SLNB) or axillary lymph node dissection (ALND)). MATERIALS AND METHODS: Ninety four breast cancer patients were enrolled in the study who underwent total mastectomy with ALND or SLNB. The patients were randomized into two groups, one treated with ORC plus closed suction drainage and the other with closed suction drainage alone. RESULTS: Mean drainage volume was slightly lower in the ORC group on postoperative day 1 (123 ± 54 vs 143 ± 104 ml), but was slightly higher at all other time points; however, these differences were not significant. Mean total drainage volume in patients treated with ORC plus drainage did not differ from that of patients treated with drainage alone (1134 ± 507 ml vs 1033 ± 643 ml, P = 0.486). CONCLUSIONS: Use of ORC (SurgiGuard(®)) did not significantly alter the risk of seroma formation.
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spelling pubmed-91402582022-05-28 The efficacy of oxidized regenerated cellulose (SurgiGuard(®)) in breast cancer patients who undergo total mastectomy with node surgery: A prospective randomized study in 94 patients Nam, Kug Hyun Lee, Joon-Hyop Chung, Yoo Seung Chun, Yong Soon Park, Heung Kyu Kim, Yun Yeong PLoS One Research Article BACKGROUND: Seromas frequently develop in patients who undergo total mastectomy with node surgery. We aimed to prospectively explore whether use of oxidized regenerated cellulose (ORC, SurgiGuard(®)) affects seroma formation after total mastectomy with node surgery (sentinel lymph node biopsy (SLNB) or axillary lymph node dissection (ALND)). MATERIALS AND METHODS: Ninety four breast cancer patients were enrolled in the study who underwent total mastectomy with ALND or SLNB. The patients were randomized into two groups, one treated with ORC plus closed suction drainage and the other with closed suction drainage alone. RESULTS: Mean drainage volume was slightly lower in the ORC group on postoperative day 1 (123 ± 54 vs 143 ± 104 ml), but was slightly higher at all other time points; however, these differences were not significant. Mean total drainage volume in patients treated with ORC plus drainage did not differ from that of patients treated with drainage alone (1134 ± 507 ml vs 1033 ± 643 ml, P = 0.486). CONCLUSIONS: Use of ORC (SurgiGuard(®)) did not significantly alter the risk of seroma formation. Public Library of Science 2022-05-27 /pmc/articles/PMC9140258/ /pubmed/35622779 http://dx.doi.org/10.1371/journal.pone.0267694 Text en © 2022 Nam et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Nam, Kug Hyun
Lee, Joon-Hyop
Chung, Yoo Seung
Chun, Yong Soon
Park, Heung Kyu
Kim, Yun Yeong
The efficacy of oxidized regenerated cellulose (SurgiGuard(®)) in breast cancer patients who undergo total mastectomy with node surgery: A prospective randomized study in 94 patients
title The efficacy of oxidized regenerated cellulose (SurgiGuard(®)) in breast cancer patients who undergo total mastectomy with node surgery: A prospective randomized study in 94 patients
title_full The efficacy of oxidized regenerated cellulose (SurgiGuard(®)) in breast cancer patients who undergo total mastectomy with node surgery: A prospective randomized study in 94 patients
title_fullStr The efficacy of oxidized regenerated cellulose (SurgiGuard(®)) in breast cancer patients who undergo total mastectomy with node surgery: A prospective randomized study in 94 patients
title_full_unstemmed The efficacy of oxidized regenerated cellulose (SurgiGuard(®)) in breast cancer patients who undergo total mastectomy with node surgery: A prospective randomized study in 94 patients
title_short The efficacy of oxidized regenerated cellulose (SurgiGuard(®)) in breast cancer patients who undergo total mastectomy with node surgery: A prospective randomized study in 94 patients
title_sort efficacy of oxidized regenerated cellulose (surgiguard(®)) in breast cancer patients who undergo total mastectomy with node surgery: a prospective randomized study in 94 patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9140258/
https://www.ncbi.nlm.nih.gov/pubmed/35622779
http://dx.doi.org/10.1371/journal.pone.0267694
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