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Shorter Incubation Period among COVID-19 Cases with the BA.1 Omicron Variant

We aimed to elucidate the range of the incubation period in patients infected with the SARS-CoV-2 Omicron variant in comparison with the Alpha variant. Contact tracing data from three Japanese public health centers (total residents, 1.06 million) collected following the guidelines of the Infectious...

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Autores principales: Tanaka, Hideo, Ogata, Tsuyoshi, Shibata, Toshiyuki, Nagai, Hitomi, Takahashi, Yuki, Kinoshita, Masaru, Matsubayashi, Keisuke, Hattori, Sanae, Taniguchi, Chie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9140418/
https://www.ncbi.nlm.nih.gov/pubmed/35627870
http://dx.doi.org/10.3390/ijerph19106330
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author Tanaka, Hideo
Ogata, Tsuyoshi
Shibata, Toshiyuki
Nagai, Hitomi
Takahashi, Yuki
Kinoshita, Masaru
Matsubayashi, Keisuke
Hattori, Sanae
Taniguchi, Chie
author_facet Tanaka, Hideo
Ogata, Tsuyoshi
Shibata, Toshiyuki
Nagai, Hitomi
Takahashi, Yuki
Kinoshita, Masaru
Matsubayashi, Keisuke
Hattori, Sanae
Taniguchi, Chie
author_sort Tanaka, Hideo
collection PubMed
description We aimed to elucidate the range of the incubation period in patients infected with the SARS-CoV-2 Omicron variant in comparison with the Alpha variant. Contact tracing data from three Japanese public health centers (total residents, 1.06 million) collected following the guidelines of the Infectious Diseases Control Law were reviewed for 1589 PCR-confirmed COVID-19 cases diagnosed in January 2022. We identified 77 eligible symptomatic patients for whom the date and setting of transmission were known, in the absence of any other probable routes of transmission. The observed incubation period was 3.03 ± 1.35 days (mean ± SDM). In the log-normal distribution, 5th, 50th and 95th percentile values were 1.3 days (95% CI: 1.0–1.6), 2.8 days (2.5–3.1) and 5.8 days (4.8–7.5), significantly shorter than among the 51 patients with the Alpha variant diagnosed in April and May in 2021 (4.94 days ± 2.19, 2.1 days (1.5–2.7), 4.5 days (4.0–5.1) and 9.6 days (7.4–13.0), p < 0.001). As this incubation period, mainly of sublineage BA.1, is even shorter than that in the Delta variant, it is thought to partially explain the variant replacement occurring in late 2021 to early 2022 in many countries.
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spelling pubmed-91404182022-05-28 Shorter Incubation Period among COVID-19 Cases with the BA.1 Omicron Variant Tanaka, Hideo Ogata, Tsuyoshi Shibata, Toshiyuki Nagai, Hitomi Takahashi, Yuki Kinoshita, Masaru Matsubayashi, Keisuke Hattori, Sanae Taniguchi, Chie Int J Environ Res Public Health Article We aimed to elucidate the range of the incubation period in patients infected with the SARS-CoV-2 Omicron variant in comparison with the Alpha variant. Contact tracing data from three Japanese public health centers (total residents, 1.06 million) collected following the guidelines of the Infectious Diseases Control Law were reviewed for 1589 PCR-confirmed COVID-19 cases diagnosed in January 2022. We identified 77 eligible symptomatic patients for whom the date and setting of transmission were known, in the absence of any other probable routes of transmission. The observed incubation period was 3.03 ± 1.35 days (mean ± SDM). In the log-normal distribution, 5th, 50th and 95th percentile values were 1.3 days (95% CI: 1.0–1.6), 2.8 days (2.5–3.1) and 5.8 days (4.8–7.5), significantly shorter than among the 51 patients with the Alpha variant diagnosed in April and May in 2021 (4.94 days ± 2.19, 2.1 days (1.5–2.7), 4.5 days (4.0–5.1) and 9.6 days (7.4–13.0), p < 0.001). As this incubation period, mainly of sublineage BA.1, is even shorter than that in the Delta variant, it is thought to partially explain the variant replacement occurring in late 2021 to early 2022 in many countries. MDPI 2022-05-23 /pmc/articles/PMC9140418/ /pubmed/35627870 http://dx.doi.org/10.3390/ijerph19106330 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tanaka, Hideo
Ogata, Tsuyoshi
Shibata, Toshiyuki
Nagai, Hitomi
Takahashi, Yuki
Kinoshita, Masaru
Matsubayashi, Keisuke
Hattori, Sanae
Taniguchi, Chie
Shorter Incubation Period among COVID-19 Cases with the BA.1 Omicron Variant
title Shorter Incubation Period among COVID-19 Cases with the BA.1 Omicron Variant
title_full Shorter Incubation Period among COVID-19 Cases with the BA.1 Omicron Variant
title_fullStr Shorter Incubation Period among COVID-19 Cases with the BA.1 Omicron Variant
title_full_unstemmed Shorter Incubation Period among COVID-19 Cases with the BA.1 Omicron Variant
title_short Shorter Incubation Period among COVID-19 Cases with the BA.1 Omicron Variant
title_sort shorter incubation period among covid-19 cases with the ba.1 omicron variant
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9140418/
https://www.ncbi.nlm.nih.gov/pubmed/35627870
http://dx.doi.org/10.3390/ijerph19106330
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