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Expression Pattern of nos1 in the Developing Nervous System of Ray-Finned Fish

Fish have colonized nearly all aquatic niches, making them an invaluable resource to understand vertebrate adaptation and gene family evolution, including the evolution of complex neural networks and modulatory neurotransmitter pathways. Among ancient regulatory molecules, the gaseous messenger nitr...

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Autores principales: Annona, Giovanni, Ferran, José Luis, De Luca, Pasquale, Conte, Ivan, Postlethwait, John H., D’Aniello, Salvatore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9140475/
https://www.ncbi.nlm.nih.gov/pubmed/35627303
http://dx.doi.org/10.3390/genes13050918
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author Annona, Giovanni
Ferran, José Luis
De Luca, Pasquale
Conte, Ivan
Postlethwait, John H.
D’Aniello, Salvatore
author_facet Annona, Giovanni
Ferran, José Luis
De Luca, Pasquale
Conte, Ivan
Postlethwait, John H.
D’Aniello, Salvatore
author_sort Annona, Giovanni
collection PubMed
description Fish have colonized nearly all aquatic niches, making them an invaluable resource to understand vertebrate adaptation and gene family evolution, including the evolution of complex neural networks and modulatory neurotransmitter pathways. Among ancient regulatory molecules, the gaseous messenger nitric oxide (NO) is involved in a wide range of biological processes. Because of its short half-life, the modulatory capability of NO is strictly related to the local activity of nitric oxide synthases (Nos), enzymes that synthesize NO from L-arginine, making the localization of Nos mRNAs a reliable indirect proxy for the location of NO action domains, targets, and effectors. Within the diversified actinopterygian nos paralogs, nos1 (alias nnos) is ubiquitously present as a single copy gene across the gnathostome lineage, making it an ideal candidate for comparative studies. To investigate variations in the NO system across ray-finned fish phylogeny, we compared nos1 expression patterns during the development of two well-established experimental teleosts (zebrafish and medaka) with an early branching holostean (spotted gar), an important evolutionary bridge between teleosts and tetrapods. Data reported here highlight both conserved expression domains and species-specific nos1 territories, confirming the ancestry of this signaling system and expanding the number of biological processes implicated in NO activities.
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spelling pubmed-91404752022-05-28 Expression Pattern of nos1 in the Developing Nervous System of Ray-Finned Fish Annona, Giovanni Ferran, José Luis De Luca, Pasquale Conte, Ivan Postlethwait, John H. D’Aniello, Salvatore Genes (Basel) Article Fish have colonized nearly all aquatic niches, making them an invaluable resource to understand vertebrate adaptation and gene family evolution, including the evolution of complex neural networks and modulatory neurotransmitter pathways. Among ancient regulatory molecules, the gaseous messenger nitric oxide (NO) is involved in a wide range of biological processes. Because of its short half-life, the modulatory capability of NO is strictly related to the local activity of nitric oxide synthases (Nos), enzymes that synthesize NO from L-arginine, making the localization of Nos mRNAs a reliable indirect proxy for the location of NO action domains, targets, and effectors. Within the diversified actinopterygian nos paralogs, nos1 (alias nnos) is ubiquitously present as a single copy gene across the gnathostome lineage, making it an ideal candidate for comparative studies. To investigate variations in the NO system across ray-finned fish phylogeny, we compared nos1 expression patterns during the development of two well-established experimental teleosts (zebrafish and medaka) with an early branching holostean (spotted gar), an important evolutionary bridge between teleosts and tetrapods. Data reported here highlight both conserved expression domains and species-specific nos1 territories, confirming the ancestry of this signaling system and expanding the number of biological processes implicated in NO activities. MDPI 2022-05-20 /pmc/articles/PMC9140475/ /pubmed/35627303 http://dx.doi.org/10.3390/genes13050918 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Annona, Giovanni
Ferran, José Luis
De Luca, Pasquale
Conte, Ivan
Postlethwait, John H.
D’Aniello, Salvatore
Expression Pattern of nos1 in the Developing Nervous System of Ray-Finned Fish
title Expression Pattern of nos1 in the Developing Nervous System of Ray-Finned Fish
title_full Expression Pattern of nos1 in the Developing Nervous System of Ray-Finned Fish
title_fullStr Expression Pattern of nos1 in the Developing Nervous System of Ray-Finned Fish
title_full_unstemmed Expression Pattern of nos1 in the Developing Nervous System of Ray-Finned Fish
title_short Expression Pattern of nos1 in the Developing Nervous System of Ray-Finned Fish
title_sort expression pattern of nos1 in the developing nervous system of ray-finned fish
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9140475/
https://www.ncbi.nlm.nih.gov/pubmed/35627303
http://dx.doi.org/10.3390/genes13050918
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