Decreased Tissue Omega-6/Omega-3 Fatty Acid Ratio Prevents Chemotherapy-Induced Gastrointestinal Toxicity Associated with Alterations of Gut Microbiome

Gastrointestinal toxicity (GIT) is a debilitating side effect of Irinotecan (CPT-11) and limits its clinical utility. Gut dysbiosis has been shown to mediate this side effect of CPT-11 by increasing gut bacterial β-glucuronidase (GUSB) activity and impairing the intestinal mucosal barrier (IMB). We...

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Detalles Bibliográficos
Autores principales: Kaliannan, Kanakaraju, Donnell, Shane O., Murphy, Kiera, Stanton, Catherine, Kang, Chao, Wang, Bin, Li, Xiang-Yong, Bhan, Atul K., Kang, Jing X.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9140600/
https://www.ncbi.nlm.nih.gov/pubmed/35628140
http://dx.doi.org/10.3390/ijms23105332

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9140600/
https://www.ncbi.nlm.nih.gov/pubmed/35628140
http://dx.doi.org/10.3390/ijms23105332

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