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Optimal Conspicuity of Liver Metastases in Virtual Monochromatic Imaging Reconstructions on a Novel Photon-Counting Detector CT—Effect of keV Settings and BMI

In dual-energy CT datasets, the conspicuity of liver metastases can be enhanced by virtual monoenergetic imaging (VMI) reconstructions at low keV levels. Our study investigated whether this effect can be reproduced in photon-counting detector CT (PCD-CT) datasets. We analyzed 100 patients with liver...

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Autores principales: Bette, Stefanie, Decker, Josua A., Braun, Franziska M., Becker, Judith, Haerting, Mark, Haeckel, Thomas, Gebhard, Michael, Risch, Franka, Woźnicki, Piotr, Scheurig-Muenkler, Christian, Kroencke, Thomas J., Schwarz, Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9140684/
https://www.ncbi.nlm.nih.gov/pubmed/35626387
http://dx.doi.org/10.3390/diagnostics12051231
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author Bette, Stefanie
Decker, Josua A.
Braun, Franziska M.
Becker, Judith
Haerting, Mark
Haeckel, Thomas
Gebhard, Michael
Risch, Franka
Woźnicki, Piotr
Scheurig-Muenkler, Christian
Kroencke, Thomas J.
Schwarz, Florian
author_facet Bette, Stefanie
Decker, Josua A.
Braun, Franziska M.
Becker, Judith
Haerting, Mark
Haeckel, Thomas
Gebhard, Michael
Risch, Franka
Woźnicki, Piotr
Scheurig-Muenkler, Christian
Kroencke, Thomas J.
Schwarz, Florian
author_sort Bette, Stefanie
collection PubMed
description In dual-energy CT datasets, the conspicuity of liver metastases can be enhanced by virtual monoenergetic imaging (VMI) reconstructions at low keV levels. Our study investigated whether this effect can be reproduced in photon-counting detector CT (PCD-CT) datasets. We analyzed 100 patients with liver metastases who had undergone contrast-enhanced CT of the abdomen on a PCD-CT (n = 50) or energy-integrating detector CT (EID-CT, single-energy mode, n = 50). PCD-VMI-reconstructions were performed at various keV levels. Identical regions of interest were positioned in metastases, normal liver, and other defined locations assessing image noise, tumor-to-liver ratio (TLR), and contrast-to-noise ratio (CNR). Patients were compared inter-individually. Subgroup analyses were performed according to BMI. On the PCD-CT, noise and CNR peaked at the low end of the keV spectrum. In comparison with the EID-CT, PCD-VMI-reconstructions exhibited lower image noise (at 70 keV) but higher CNR (for ≤70 keV), despite similar CTDIs. Comparing high- and low-BMI patients, CTDI-upregulation was more modest for the PCD-CT but still resulted in similar noise levels and preserved CNR, unlike the EID-CT. In conclusion, PCD-CT VMIs in oncologic patients demonstrated reduced image noise–compared to a standard EID-CT–and improved conspicuity of hypovascularized liver metastases at low keV values. Patients with higher BMIs especially benefited from constant image noise and preservation of lesion conspicuity, despite a more moderate upregulation of CTDI.
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spelling pubmed-91406842022-05-28 Optimal Conspicuity of Liver Metastases in Virtual Monochromatic Imaging Reconstructions on a Novel Photon-Counting Detector CT—Effect of keV Settings and BMI Bette, Stefanie Decker, Josua A. Braun, Franziska M. Becker, Judith Haerting, Mark Haeckel, Thomas Gebhard, Michael Risch, Franka Woźnicki, Piotr Scheurig-Muenkler, Christian Kroencke, Thomas J. Schwarz, Florian Diagnostics (Basel) Article In dual-energy CT datasets, the conspicuity of liver metastases can be enhanced by virtual monoenergetic imaging (VMI) reconstructions at low keV levels. Our study investigated whether this effect can be reproduced in photon-counting detector CT (PCD-CT) datasets. We analyzed 100 patients with liver metastases who had undergone contrast-enhanced CT of the abdomen on a PCD-CT (n = 50) or energy-integrating detector CT (EID-CT, single-energy mode, n = 50). PCD-VMI-reconstructions were performed at various keV levels. Identical regions of interest were positioned in metastases, normal liver, and other defined locations assessing image noise, tumor-to-liver ratio (TLR), and contrast-to-noise ratio (CNR). Patients were compared inter-individually. Subgroup analyses were performed according to BMI. On the PCD-CT, noise and CNR peaked at the low end of the keV spectrum. In comparison with the EID-CT, PCD-VMI-reconstructions exhibited lower image noise (at 70 keV) but higher CNR (for ≤70 keV), despite similar CTDIs. Comparing high- and low-BMI patients, CTDI-upregulation was more modest for the PCD-CT but still resulted in similar noise levels and preserved CNR, unlike the EID-CT. In conclusion, PCD-CT VMIs in oncologic patients demonstrated reduced image noise–compared to a standard EID-CT–and improved conspicuity of hypovascularized liver metastases at low keV values. Patients with higher BMIs especially benefited from constant image noise and preservation of lesion conspicuity, despite a more moderate upregulation of CTDI. MDPI 2022-05-14 /pmc/articles/PMC9140684/ /pubmed/35626387 http://dx.doi.org/10.3390/diagnostics12051231 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bette, Stefanie
Decker, Josua A.
Braun, Franziska M.
Becker, Judith
Haerting, Mark
Haeckel, Thomas
Gebhard, Michael
Risch, Franka
Woźnicki, Piotr
Scheurig-Muenkler, Christian
Kroencke, Thomas J.
Schwarz, Florian
Optimal Conspicuity of Liver Metastases in Virtual Monochromatic Imaging Reconstructions on a Novel Photon-Counting Detector CT—Effect of keV Settings and BMI
title Optimal Conspicuity of Liver Metastases in Virtual Monochromatic Imaging Reconstructions on a Novel Photon-Counting Detector CT—Effect of keV Settings and BMI
title_full Optimal Conspicuity of Liver Metastases in Virtual Monochromatic Imaging Reconstructions on a Novel Photon-Counting Detector CT—Effect of keV Settings and BMI
title_fullStr Optimal Conspicuity of Liver Metastases in Virtual Monochromatic Imaging Reconstructions on a Novel Photon-Counting Detector CT—Effect of keV Settings and BMI
title_full_unstemmed Optimal Conspicuity of Liver Metastases in Virtual Monochromatic Imaging Reconstructions on a Novel Photon-Counting Detector CT—Effect of keV Settings and BMI
title_short Optimal Conspicuity of Liver Metastases in Virtual Monochromatic Imaging Reconstructions on a Novel Photon-Counting Detector CT—Effect of keV Settings and BMI
title_sort optimal conspicuity of liver metastases in virtual monochromatic imaging reconstructions on a novel photon-counting detector ct—effect of kev settings and bmi
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9140684/
https://www.ncbi.nlm.nih.gov/pubmed/35626387
http://dx.doi.org/10.3390/diagnostics12051231
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