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Anti-Diabetic Activity of Polysaccharides from Auricularia cornea var. Li.

Auricularia cornea var. Li. polysaccharide (ACP) has many important biological activities and has potential application value in food engineering, pharmaceutical science, and health care. The results were as follows: the extraction rate of ACP was 28.18% ± 1.41% and the purity of ACP was 86.92% ± 2....

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Autores principales: Fu, Yuan, Wang, Liwen, Jiang, Guochuan, Ren, Lili, Wang, Liyan, Liu, Xuejun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9140784/
https://www.ncbi.nlm.nih.gov/pubmed/35627036
http://dx.doi.org/10.3390/foods11101464
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author Fu, Yuan
Wang, Liwen
Jiang, Guochuan
Ren, Lili
Wang, Liyan
Liu, Xuejun
author_facet Fu, Yuan
Wang, Liwen
Jiang, Guochuan
Ren, Lili
Wang, Liyan
Liu, Xuejun
author_sort Fu, Yuan
collection PubMed
description Auricularia cornea var. Li. polysaccharide (ACP) has many important biological activities and has potential application value in food engineering, pharmaceutical science, and health care. The results were as follows: the extraction rate of ACP was 28.18% ± 1.41% and the purity of ACP was 86.92% ± 2.80%. ACP contains mannitol 32.41%, glucuronic acid 6.96%, rhamnose 0.32%, glucose 42.35%, galactose 0.77%, xylose 16.83%, and fucose 0.36%, without galacturonic acid and arabinose. In addition, the results of an animal test of diabetes mellitus II (DM II) with ACP showed that the total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and fasting blood glucose and water in the serum of mice with ACP were significantly lower than those in the model group; the serum SOD, hepatic glycogen, and insulin of mice added with ACP were significantly higher than those in the model group. More importantly, ACP had no significant adverse effects on organ index and liver and kidney tissue morphology in mice. These results suggest that ACP can be used as a potential functional food component for the prevention or treatment of diabetes.
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spelling pubmed-91407842022-05-28 Anti-Diabetic Activity of Polysaccharides from Auricularia cornea var. Li. Fu, Yuan Wang, Liwen Jiang, Guochuan Ren, Lili Wang, Liyan Liu, Xuejun Foods Article Auricularia cornea var. Li. polysaccharide (ACP) has many important biological activities and has potential application value in food engineering, pharmaceutical science, and health care. The results were as follows: the extraction rate of ACP was 28.18% ± 1.41% and the purity of ACP was 86.92% ± 2.80%. ACP contains mannitol 32.41%, glucuronic acid 6.96%, rhamnose 0.32%, glucose 42.35%, galactose 0.77%, xylose 16.83%, and fucose 0.36%, without galacturonic acid and arabinose. In addition, the results of an animal test of diabetes mellitus II (DM II) with ACP showed that the total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and fasting blood glucose and water in the serum of mice with ACP were significantly lower than those in the model group; the serum SOD, hepatic glycogen, and insulin of mice added with ACP were significantly higher than those in the model group. More importantly, ACP had no significant adverse effects on organ index and liver and kidney tissue morphology in mice. These results suggest that ACP can be used as a potential functional food component for the prevention or treatment of diabetes. MDPI 2022-05-18 /pmc/articles/PMC9140784/ /pubmed/35627036 http://dx.doi.org/10.3390/foods11101464 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fu, Yuan
Wang, Liwen
Jiang, Guochuan
Ren, Lili
Wang, Liyan
Liu, Xuejun
Anti-Diabetic Activity of Polysaccharides from Auricularia cornea var. Li.
title Anti-Diabetic Activity of Polysaccharides from Auricularia cornea var. Li.
title_full Anti-Diabetic Activity of Polysaccharides from Auricularia cornea var. Li.
title_fullStr Anti-Diabetic Activity of Polysaccharides from Auricularia cornea var. Li.
title_full_unstemmed Anti-Diabetic Activity of Polysaccharides from Auricularia cornea var. Li.
title_short Anti-Diabetic Activity of Polysaccharides from Auricularia cornea var. Li.
title_sort anti-diabetic activity of polysaccharides from auricularia cornea var. li.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9140784/
https://www.ncbi.nlm.nih.gov/pubmed/35627036
http://dx.doi.org/10.3390/foods11101464
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