Cargando…

The Comparison of Three Predictive Indexes to Discriminate Malignant Ovarian Tumors from Benign Ovarian Endometrioma: The Characteristics and Efficacy

This study aimed to evaluate the prediction efficacy of malignant transformation of ovarian endometrioma (OE) using the Copenhagen Index (CPH-I), the risk of ovarian malignancy algorithm (ROMA), and the R2 predictive index. This retrospective study was conducted at the Department of Gynecology, Nara...

Descripción completa

Detalles Bibliográficos
Autores principales: Yamanaka, Shoichiro, Kawahara, Naoki, Kawaguchi, Ryuji, Waki, Keita, Maehana, Tomoka, Fukui, Yosuke, Miyake, Ryuta, Yamada, Yuki, Kobayashi, Hiroshi, Kimura, Fuminori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9140823/
https://www.ncbi.nlm.nih.gov/pubmed/35626367
http://dx.doi.org/10.3390/diagnostics12051212
_version_ 1784715192167301120
author Yamanaka, Shoichiro
Kawahara, Naoki
Kawaguchi, Ryuji
Waki, Keita
Maehana, Tomoka
Fukui, Yosuke
Miyake, Ryuta
Yamada, Yuki
Kobayashi, Hiroshi
Kimura, Fuminori
author_facet Yamanaka, Shoichiro
Kawahara, Naoki
Kawaguchi, Ryuji
Waki, Keita
Maehana, Tomoka
Fukui, Yosuke
Miyake, Ryuta
Yamada, Yuki
Kobayashi, Hiroshi
Kimura, Fuminori
author_sort Yamanaka, Shoichiro
collection PubMed
description This study aimed to evaluate the prediction efficacy of malignant transformation of ovarian endometrioma (OE) using the Copenhagen Index (CPH-I), the risk of ovarian malignancy algorithm (ROMA), and the R2 predictive index. This retrospective study was conducted at the Department of Gynecology, Nara Medical University Hospital, from January 2008 to July 2021. A total of 171 patients were included in the study. In the current study, cases were divided into three cohorts: pre-menopausal, post-menopausal, and a combined cohort. Patients with benign ovarian tumor mainly received laparoscopic surgery, and patients with suspected malignant tumors underwent laparotomy. Information from a review chart of the patients’ medical records was collected. In the combined cohort, a multivariate analysis confirmed that the ROMA index, the R2 predictive index, and tumor laterality were extracted as independent factors for predicting malignant tumors (hazard ratio (HR): 222.14, 95% confidence interval (CI): 22.27–2215.50, p < 0.001; HR: 9.80, 95% CI: 2.90–33.13, p < 0.001; HR: 0.15, 95% CI: 0.03–0.75, p = 0.021, respectively). In the pre-menopausal cohort, a multivariate analysis confirmed that the CPH index and the R2 predictive index were extracted as independent factors for predicting malignant tumors (HR: 6.45, 95% CI: 1.47–28.22, p = 0.013; HR: 31.19, 95% CI: 8.48–114.74, p < 0.001, respectively). Moreover, the R2 predictive index was only extracted as an independent factor for predicting borderline tumors (HR: 45.00, 95% CI: 7.43–272.52, p < 0.001) in the combined cohort. In pre-menopausal cases or borderline cases, the R2 predictive index is useful; while, in post-menopausal cases, the ROMA index is better than the other indexes.
format Online
Article
Text
id pubmed-9140823
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-91408232022-05-28 The Comparison of Three Predictive Indexes to Discriminate Malignant Ovarian Tumors from Benign Ovarian Endometrioma: The Characteristics and Efficacy Yamanaka, Shoichiro Kawahara, Naoki Kawaguchi, Ryuji Waki, Keita Maehana, Tomoka Fukui, Yosuke Miyake, Ryuta Yamada, Yuki Kobayashi, Hiroshi Kimura, Fuminori Diagnostics (Basel) Article This study aimed to evaluate the prediction efficacy of malignant transformation of ovarian endometrioma (OE) using the Copenhagen Index (CPH-I), the risk of ovarian malignancy algorithm (ROMA), and the R2 predictive index. This retrospective study was conducted at the Department of Gynecology, Nara Medical University Hospital, from January 2008 to July 2021. A total of 171 patients were included in the study. In the current study, cases were divided into three cohorts: pre-menopausal, post-menopausal, and a combined cohort. Patients with benign ovarian tumor mainly received laparoscopic surgery, and patients with suspected malignant tumors underwent laparotomy. Information from a review chart of the patients’ medical records was collected. In the combined cohort, a multivariate analysis confirmed that the ROMA index, the R2 predictive index, and tumor laterality were extracted as independent factors for predicting malignant tumors (hazard ratio (HR): 222.14, 95% confidence interval (CI): 22.27–2215.50, p < 0.001; HR: 9.80, 95% CI: 2.90–33.13, p < 0.001; HR: 0.15, 95% CI: 0.03–0.75, p = 0.021, respectively). In the pre-menopausal cohort, a multivariate analysis confirmed that the CPH index and the R2 predictive index were extracted as independent factors for predicting malignant tumors (HR: 6.45, 95% CI: 1.47–28.22, p = 0.013; HR: 31.19, 95% CI: 8.48–114.74, p < 0.001, respectively). Moreover, the R2 predictive index was only extracted as an independent factor for predicting borderline tumors (HR: 45.00, 95% CI: 7.43–272.52, p < 0.001) in the combined cohort. In pre-menopausal cases or borderline cases, the R2 predictive index is useful; while, in post-menopausal cases, the ROMA index is better than the other indexes. MDPI 2022-05-12 /pmc/articles/PMC9140823/ /pubmed/35626367 http://dx.doi.org/10.3390/diagnostics12051212 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yamanaka, Shoichiro
Kawahara, Naoki
Kawaguchi, Ryuji
Waki, Keita
Maehana, Tomoka
Fukui, Yosuke
Miyake, Ryuta
Yamada, Yuki
Kobayashi, Hiroshi
Kimura, Fuminori
The Comparison of Three Predictive Indexes to Discriminate Malignant Ovarian Tumors from Benign Ovarian Endometrioma: The Characteristics and Efficacy
title The Comparison of Three Predictive Indexes to Discriminate Malignant Ovarian Tumors from Benign Ovarian Endometrioma: The Characteristics and Efficacy
title_full The Comparison of Three Predictive Indexes to Discriminate Malignant Ovarian Tumors from Benign Ovarian Endometrioma: The Characteristics and Efficacy
title_fullStr The Comparison of Three Predictive Indexes to Discriminate Malignant Ovarian Tumors from Benign Ovarian Endometrioma: The Characteristics and Efficacy
title_full_unstemmed The Comparison of Three Predictive Indexes to Discriminate Malignant Ovarian Tumors from Benign Ovarian Endometrioma: The Characteristics and Efficacy
title_short The Comparison of Three Predictive Indexes to Discriminate Malignant Ovarian Tumors from Benign Ovarian Endometrioma: The Characteristics and Efficacy
title_sort comparison of three predictive indexes to discriminate malignant ovarian tumors from benign ovarian endometrioma: the characteristics and efficacy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9140823/
https://www.ncbi.nlm.nih.gov/pubmed/35626367
http://dx.doi.org/10.3390/diagnostics12051212
work_keys_str_mv AT yamanakashoichiro thecomparisonofthreepredictiveindexestodiscriminatemalignantovariantumorsfrombenignovarianendometriomathecharacteristicsandefficacy
AT kawaharanaoki thecomparisonofthreepredictiveindexestodiscriminatemalignantovariantumorsfrombenignovarianendometriomathecharacteristicsandefficacy
AT kawaguchiryuji thecomparisonofthreepredictiveindexestodiscriminatemalignantovariantumorsfrombenignovarianendometriomathecharacteristicsandefficacy
AT wakikeita thecomparisonofthreepredictiveindexestodiscriminatemalignantovariantumorsfrombenignovarianendometriomathecharacteristicsandefficacy
AT maehanatomoka thecomparisonofthreepredictiveindexestodiscriminatemalignantovariantumorsfrombenignovarianendometriomathecharacteristicsandefficacy
AT fukuiyosuke thecomparisonofthreepredictiveindexestodiscriminatemalignantovariantumorsfrombenignovarianendometriomathecharacteristicsandefficacy
AT miyakeryuta thecomparisonofthreepredictiveindexestodiscriminatemalignantovariantumorsfrombenignovarianendometriomathecharacteristicsandefficacy
AT yamadayuki thecomparisonofthreepredictiveindexestodiscriminatemalignantovariantumorsfrombenignovarianendometriomathecharacteristicsandefficacy
AT kobayashihiroshi thecomparisonofthreepredictiveindexestodiscriminatemalignantovariantumorsfrombenignovarianendometriomathecharacteristicsandefficacy
AT kimurafuminori thecomparisonofthreepredictiveindexestodiscriminatemalignantovariantumorsfrombenignovarianendometriomathecharacteristicsandefficacy
AT yamanakashoichiro comparisonofthreepredictiveindexestodiscriminatemalignantovariantumorsfrombenignovarianendometriomathecharacteristicsandefficacy
AT kawaharanaoki comparisonofthreepredictiveindexestodiscriminatemalignantovariantumorsfrombenignovarianendometriomathecharacteristicsandefficacy
AT kawaguchiryuji comparisonofthreepredictiveindexestodiscriminatemalignantovariantumorsfrombenignovarianendometriomathecharacteristicsandefficacy
AT wakikeita comparisonofthreepredictiveindexestodiscriminatemalignantovariantumorsfrombenignovarianendometriomathecharacteristicsandefficacy
AT maehanatomoka comparisonofthreepredictiveindexestodiscriminatemalignantovariantumorsfrombenignovarianendometriomathecharacteristicsandefficacy
AT fukuiyosuke comparisonofthreepredictiveindexestodiscriminatemalignantovariantumorsfrombenignovarianendometriomathecharacteristicsandefficacy
AT miyakeryuta comparisonofthreepredictiveindexestodiscriminatemalignantovariantumorsfrombenignovarianendometriomathecharacteristicsandefficacy
AT yamadayuki comparisonofthreepredictiveindexestodiscriminatemalignantovariantumorsfrombenignovarianendometriomathecharacteristicsandefficacy
AT kobayashihiroshi comparisonofthreepredictiveindexestodiscriminatemalignantovariantumorsfrombenignovarianendometriomathecharacteristicsandefficacy
AT kimurafuminori comparisonofthreepredictiveindexestodiscriminatemalignantovariantumorsfrombenignovarianendometriomathecharacteristicsandefficacy