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Mapping microglia and astrocyte activation in vivo using diffusion MRI
While glia are increasingly implicated in the pathophysiology of psychiatric and neurodegenerative disorders, available methods for imaging these cells in vivo involve either invasive procedures or positron emission tomography radiotracers, which afford low resolution and specificity. Here, we prese...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9140964/ https://www.ncbi.nlm.nih.gov/pubmed/35622913 http://dx.doi.org/10.1126/sciadv.abq2923 |
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author | Garcia-Hernandez, Raquel Cerdán Cerdá, Antonio Trouve Carpena, Alejandro Drakesmith, Mark Koller, Kristin Jones, Derek K. Canals, Santiago De Santis, Silvia |
author_facet | Garcia-Hernandez, Raquel Cerdán Cerdá, Antonio Trouve Carpena, Alejandro Drakesmith, Mark Koller, Kristin Jones, Derek K. Canals, Santiago De Santis, Silvia |
author_sort | Garcia-Hernandez, Raquel |
collection | PubMed |
description | While glia are increasingly implicated in the pathophysiology of psychiatric and neurodegenerative disorders, available methods for imaging these cells in vivo involve either invasive procedures or positron emission tomography radiotracers, which afford low resolution and specificity. Here, we present a noninvasive diffusion-weighted magnetic resonance imaging (MRI) method to image changes in glia morphology. Using rat models of neuroinflammation, degeneration, and demyelination, we demonstrate that diffusion-weighted MRI carries a fingerprint of microglia and astrocyte activation and that specific signatures from each population can be quantified noninvasively. The method is sensitive to changes in glia morphology and proliferation, providing a quantitative account of neuroinflammation, regardless of the existence of a concomitant neuronal loss or demyelinating injury. We prove the translational value of the approach showing significant associations between MRI and histological microglia markers in humans. This framework holds the potential to transform basic and clinical research by clarifying the role of inflammation in health and disease. |
format | Online Article Text |
id | pubmed-9140964 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-91409642022-06-01 Mapping microglia and astrocyte activation in vivo using diffusion MRI Garcia-Hernandez, Raquel Cerdán Cerdá, Antonio Trouve Carpena, Alejandro Drakesmith, Mark Koller, Kristin Jones, Derek K. Canals, Santiago De Santis, Silvia Sci Adv Neuroscience While glia are increasingly implicated in the pathophysiology of psychiatric and neurodegenerative disorders, available methods for imaging these cells in vivo involve either invasive procedures or positron emission tomography radiotracers, which afford low resolution and specificity. Here, we present a noninvasive diffusion-weighted magnetic resonance imaging (MRI) method to image changes in glia morphology. Using rat models of neuroinflammation, degeneration, and demyelination, we demonstrate that diffusion-weighted MRI carries a fingerprint of microglia and astrocyte activation and that specific signatures from each population can be quantified noninvasively. The method is sensitive to changes in glia morphology and proliferation, providing a quantitative account of neuroinflammation, regardless of the existence of a concomitant neuronal loss or demyelinating injury. We prove the translational value of the approach showing significant associations between MRI and histological microglia markers in humans. This framework holds the potential to transform basic and clinical research by clarifying the role of inflammation in health and disease. American Association for the Advancement of Science 2022-05-27 /pmc/articles/PMC9140964/ /pubmed/35622913 http://dx.doi.org/10.1126/sciadv.abq2923 Text en Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Neuroscience Garcia-Hernandez, Raquel Cerdán Cerdá, Antonio Trouve Carpena, Alejandro Drakesmith, Mark Koller, Kristin Jones, Derek K. Canals, Santiago De Santis, Silvia Mapping microglia and astrocyte activation in vivo using diffusion MRI |
title | Mapping microglia and astrocyte activation in vivo using diffusion MRI |
title_full | Mapping microglia and astrocyte activation in vivo using diffusion MRI |
title_fullStr | Mapping microglia and astrocyte activation in vivo using diffusion MRI |
title_full_unstemmed | Mapping microglia and astrocyte activation in vivo using diffusion MRI |
title_short | Mapping microglia and astrocyte activation in vivo using diffusion MRI |
title_sort | mapping microglia and astrocyte activation in vivo using diffusion mri |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9140964/ https://www.ncbi.nlm.nih.gov/pubmed/35622913 http://dx.doi.org/10.1126/sciadv.abq2923 |
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