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No Association between ABCB1 G2677T/A or C3435T Polymorphisms and Survival of Breast Cancer Patients—A 10-Year Follow-Up Study in the Polish Population

Many intensive studies are devoted to identifying novel cancer diagnostics or therapy strategies that would boost cancer therapy efficacy and recovery rates. Importantly, polymorphisms in the genes coding for ABC family proteins were considered good candidates for cancer development risk or cancer d...

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Autores principales: Totoń, Ewa, Jacczak, Barbara, Barczak, Wojciech, Jagielski, Paweł, Gryczka, Robert, Hołysz, Hanna, Grodecka-Gazdecka, Sylwia, Rubiś, Błażej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141033/
https://www.ncbi.nlm.nih.gov/pubmed/35627114
http://dx.doi.org/10.3390/genes13050729
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author Totoń, Ewa
Jacczak, Barbara
Barczak, Wojciech
Jagielski, Paweł
Gryczka, Robert
Hołysz, Hanna
Grodecka-Gazdecka, Sylwia
Rubiś, Błażej
author_facet Totoń, Ewa
Jacczak, Barbara
Barczak, Wojciech
Jagielski, Paweł
Gryczka, Robert
Hołysz, Hanna
Grodecka-Gazdecka, Sylwia
Rubiś, Błażej
author_sort Totoń, Ewa
collection PubMed
description Many intensive studies are devoted to identifying novel cancer diagnostics or therapy strategies that would boost cancer therapy efficacy and recovery rates. Importantly, polymorphisms in the genes coding for ABC family proteins were considered good candidates for cancer development risk or cancer drug resistance markers. For this reason, we decided to assess the contribution of ABCB1’s most common variants (i.e., G2677T/A in exon 21/rs2032582 and C3435T in exon 26/rs1045642) to the cancer therapy response in breast cancer patients. A 10-year follow-up analysis of 157 breast cancer patients was performed. Clinical assessment, ABCB1 polymorphism status, estrogen/progesterone/human epidermal receptors status, and other characteristics were compared according to the follow-up status using the Chi-square statistic. For the analysis of overall survival curves in TCGA breast cancer patients, the Xena browser was used. We show that neither 2677 nor 3435 polymorphisms contributed to the survival of breast cancer patients. Interestingly, but not surprisingly, estrogen and progesterone receptors status were good prognostic factors and positively correlated with a disease-free survival for up to 10 years. To summarize, ABCB1 polymorphisms status may be one of the numerous factors that affect cancer development. However, they may not be the critical ones when it comes to risk or recovery assessment. Consequently, they may not be treated as reliable prognostic or predictive markers in breast cancer patients’ evaluation, which supports the previous findings and current knowledge.
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spelling pubmed-91410332022-05-28 No Association between ABCB1 G2677T/A or C3435T Polymorphisms and Survival of Breast Cancer Patients—A 10-Year Follow-Up Study in the Polish Population Totoń, Ewa Jacczak, Barbara Barczak, Wojciech Jagielski, Paweł Gryczka, Robert Hołysz, Hanna Grodecka-Gazdecka, Sylwia Rubiś, Błażej Genes (Basel) Article Many intensive studies are devoted to identifying novel cancer diagnostics or therapy strategies that would boost cancer therapy efficacy and recovery rates. Importantly, polymorphisms in the genes coding for ABC family proteins were considered good candidates for cancer development risk or cancer drug resistance markers. For this reason, we decided to assess the contribution of ABCB1’s most common variants (i.e., G2677T/A in exon 21/rs2032582 and C3435T in exon 26/rs1045642) to the cancer therapy response in breast cancer patients. A 10-year follow-up analysis of 157 breast cancer patients was performed. Clinical assessment, ABCB1 polymorphism status, estrogen/progesterone/human epidermal receptors status, and other characteristics were compared according to the follow-up status using the Chi-square statistic. For the analysis of overall survival curves in TCGA breast cancer patients, the Xena browser was used. We show that neither 2677 nor 3435 polymorphisms contributed to the survival of breast cancer patients. Interestingly, but not surprisingly, estrogen and progesterone receptors status were good prognostic factors and positively correlated with a disease-free survival for up to 10 years. To summarize, ABCB1 polymorphisms status may be one of the numerous factors that affect cancer development. However, they may not be the critical ones when it comes to risk or recovery assessment. Consequently, they may not be treated as reliable prognostic or predictive markers in breast cancer patients’ evaluation, which supports the previous findings and current knowledge. MDPI 2022-04-21 /pmc/articles/PMC9141033/ /pubmed/35627114 http://dx.doi.org/10.3390/genes13050729 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Totoń, Ewa
Jacczak, Barbara
Barczak, Wojciech
Jagielski, Paweł
Gryczka, Robert
Hołysz, Hanna
Grodecka-Gazdecka, Sylwia
Rubiś, Błażej
No Association between ABCB1 G2677T/A or C3435T Polymorphisms and Survival of Breast Cancer Patients—A 10-Year Follow-Up Study in the Polish Population
title No Association between ABCB1 G2677T/A or C3435T Polymorphisms and Survival of Breast Cancer Patients—A 10-Year Follow-Up Study in the Polish Population
title_full No Association between ABCB1 G2677T/A or C3435T Polymorphisms and Survival of Breast Cancer Patients—A 10-Year Follow-Up Study in the Polish Population
title_fullStr No Association between ABCB1 G2677T/A or C3435T Polymorphisms and Survival of Breast Cancer Patients—A 10-Year Follow-Up Study in the Polish Population
title_full_unstemmed No Association between ABCB1 G2677T/A or C3435T Polymorphisms and Survival of Breast Cancer Patients—A 10-Year Follow-Up Study in the Polish Population
title_short No Association between ABCB1 G2677T/A or C3435T Polymorphisms and Survival of Breast Cancer Patients—A 10-Year Follow-Up Study in the Polish Population
title_sort no association between abcb1 g2677t/a or c3435t polymorphisms and survival of breast cancer patients—a 10-year follow-up study in the polish population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141033/
https://www.ncbi.nlm.nih.gov/pubmed/35627114
http://dx.doi.org/10.3390/genes13050729
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