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Thermo-Sensitive mPEG-PA-PLL Hydrogel for Drug Release of Calcitonin
The oral route is the most popular way of drug administration because of good patient compliance and ease of use. However, the oral delivery of peptides and proteins is difficult, mainly due to poor oral bioavailability. In past decades, researchers have developed several strategies to improve oral...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141101/ https://www.ncbi.nlm.nih.gov/pubmed/35621580 http://dx.doi.org/10.3390/gels8050282 |
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author | Cheng, Yu-En Wu, I-En Chen, Yi-Chen Chu, I-Ming |
author_facet | Cheng, Yu-En Wu, I-En Chen, Yi-Chen Chu, I-Ming |
author_sort | Cheng, Yu-En |
collection | PubMed |
description | The oral route is the most popular way of drug administration because of good patient compliance and ease of use. However, the oral delivery of peptides and proteins is difficult, mainly due to poor oral bioavailability. In past decades, researchers have developed several strategies to improve oral bioavailability by avoiding losing activity in the gastrointestinal (GI) tract and enhancing the intestinal permeability of these drugs. Methoxy poly(ethylene glycol)-poly(l-alanine) (mPEG-PA) is a thermo-sensitive hydrogel exhibiting a sol-to-gel phase transition property. This characteristic is appropriate for encapsulating peptide or protein drugs. To enhance the adhesion ability to intestinal mucus, a thermo-sensitive polymer, mPEG-PA, modified with charged amino acid lysine was developed. This positively charged material would help to bind the negatively charged mucin in mucus. The synthesis was conducted by individually synthesizing mPEG-PA and poly(l-lysine) (PLL) of different lengths via ring-opening polymerization. Then, mPEG-PA and PLL were combined using an NHS ester reaction to synthesize the triblock copolymer (mPEG-PA-PLL). Biocompatibility and the release of calcitonin from the synthesized hydrogel particles under different pH were examined. The initial data showed that the newly design material had a promising potential for the oral delivery of peptide drugs. |
format | Online Article Text |
id | pubmed-9141101 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91411012022-05-28 Thermo-Sensitive mPEG-PA-PLL Hydrogel for Drug Release of Calcitonin Cheng, Yu-En Wu, I-En Chen, Yi-Chen Chu, I-Ming Gels Article The oral route is the most popular way of drug administration because of good patient compliance and ease of use. However, the oral delivery of peptides and proteins is difficult, mainly due to poor oral bioavailability. In past decades, researchers have developed several strategies to improve oral bioavailability by avoiding losing activity in the gastrointestinal (GI) tract and enhancing the intestinal permeability of these drugs. Methoxy poly(ethylene glycol)-poly(l-alanine) (mPEG-PA) is a thermo-sensitive hydrogel exhibiting a sol-to-gel phase transition property. This characteristic is appropriate for encapsulating peptide or protein drugs. To enhance the adhesion ability to intestinal mucus, a thermo-sensitive polymer, mPEG-PA, modified with charged amino acid lysine was developed. This positively charged material would help to bind the negatively charged mucin in mucus. The synthesis was conducted by individually synthesizing mPEG-PA and poly(l-lysine) (PLL) of different lengths via ring-opening polymerization. Then, mPEG-PA and PLL were combined using an NHS ester reaction to synthesize the triblock copolymer (mPEG-PA-PLL). Biocompatibility and the release of calcitonin from the synthesized hydrogel particles under different pH were examined. The initial data showed that the newly design material had a promising potential for the oral delivery of peptide drugs. MDPI 2022-05-02 /pmc/articles/PMC9141101/ /pubmed/35621580 http://dx.doi.org/10.3390/gels8050282 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Cheng, Yu-En Wu, I-En Chen, Yi-Chen Chu, I-Ming Thermo-Sensitive mPEG-PA-PLL Hydrogel for Drug Release of Calcitonin |
title | Thermo-Sensitive mPEG-PA-PLL Hydrogel for Drug Release of Calcitonin |
title_full | Thermo-Sensitive mPEG-PA-PLL Hydrogel for Drug Release of Calcitonin |
title_fullStr | Thermo-Sensitive mPEG-PA-PLL Hydrogel for Drug Release of Calcitonin |
title_full_unstemmed | Thermo-Sensitive mPEG-PA-PLL Hydrogel for Drug Release of Calcitonin |
title_short | Thermo-Sensitive mPEG-PA-PLL Hydrogel for Drug Release of Calcitonin |
title_sort | thermo-sensitive mpeg-pa-pll hydrogel for drug release of calcitonin |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141101/ https://www.ncbi.nlm.nih.gov/pubmed/35621580 http://dx.doi.org/10.3390/gels8050282 |
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