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Thermo-Sensitive mPEG-PA-PLL Hydrogel for Drug Release of Calcitonin

The oral route is the most popular way of drug administration because of good patient compliance and ease of use. However, the oral delivery of peptides and proteins is difficult, mainly due to poor oral bioavailability. In past decades, researchers have developed several strategies to improve oral...

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Autores principales: Cheng, Yu-En, Wu, I-En, Chen, Yi-Chen, Chu, I-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141101/
https://www.ncbi.nlm.nih.gov/pubmed/35621580
http://dx.doi.org/10.3390/gels8050282
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author Cheng, Yu-En
Wu, I-En
Chen, Yi-Chen
Chu, I-Ming
author_facet Cheng, Yu-En
Wu, I-En
Chen, Yi-Chen
Chu, I-Ming
author_sort Cheng, Yu-En
collection PubMed
description The oral route is the most popular way of drug administration because of good patient compliance and ease of use. However, the oral delivery of peptides and proteins is difficult, mainly due to poor oral bioavailability. In past decades, researchers have developed several strategies to improve oral bioavailability by avoiding losing activity in the gastrointestinal (GI) tract and enhancing the intestinal permeability of these drugs. Methoxy poly(ethylene glycol)-poly(l-alanine) (mPEG-PA) is a thermo-sensitive hydrogel exhibiting a sol-to-gel phase transition property. This characteristic is appropriate for encapsulating peptide or protein drugs. To enhance the adhesion ability to intestinal mucus, a thermo-sensitive polymer, mPEG-PA, modified with charged amino acid lysine was developed. This positively charged material would help to bind the negatively charged mucin in mucus. The synthesis was conducted by individually synthesizing mPEG-PA and poly(l-lysine) (PLL) of different lengths via ring-opening polymerization. Then, mPEG-PA and PLL were combined using an NHS ester reaction to synthesize the triblock copolymer (mPEG-PA-PLL). Biocompatibility and the release of calcitonin from the synthesized hydrogel particles under different pH were examined. The initial data showed that the newly design material had a promising potential for the oral delivery of peptide drugs.
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spelling pubmed-91411012022-05-28 Thermo-Sensitive mPEG-PA-PLL Hydrogel for Drug Release of Calcitonin Cheng, Yu-En Wu, I-En Chen, Yi-Chen Chu, I-Ming Gels Article The oral route is the most popular way of drug administration because of good patient compliance and ease of use. However, the oral delivery of peptides and proteins is difficult, mainly due to poor oral bioavailability. In past decades, researchers have developed several strategies to improve oral bioavailability by avoiding losing activity in the gastrointestinal (GI) tract and enhancing the intestinal permeability of these drugs. Methoxy poly(ethylene glycol)-poly(l-alanine) (mPEG-PA) is a thermo-sensitive hydrogel exhibiting a sol-to-gel phase transition property. This characteristic is appropriate for encapsulating peptide or protein drugs. To enhance the adhesion ability to intestinal mucus, a thermo-sensitive polymer, mPEG-PA, modified with charged amino acid lysine was developed. This positively charged material would help to bind the negatively charged mucin in mucus. The synthesis was conducted by individually synthesizing mPEG-PA and poly(l-lysine) (PLL) of different lengths via ring-opening polymerization. Then, mPEG-PA and PLL were combined using an NHS ester reaction to synthesize the triblock copolymer (mPEG-PA-PLL). Biocompatibility and the release of calcitonin from the synthesized hydrogel particles under different pH were examined. The initial data showed that the newly design material had a promising potential for the oral delivery of peptide drugs. MDPI 2022-05-02 /pmc/articles/PMC9141101/ /pubmed/35621580 http://dx.doi.org/10.3390/gels8050282 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cheng, Yu-En
Wu, I-En
Chen, Yi-Chen
Chu, I-Ming
Thermo-Sensitive mPEG-PA-PLL Hydrogel for Drug Release of Calcitonin
title Thermo-Sensitive mPEG-PA-PLL Hydrogel for Drug Release of Calcitonin
title_full Thermo-Sensitive mPEG-PA-PLL Hydrogel for Drug Release of Calcitonin
title_fullStr Thermo-Sensitive mPEG-PA-PLL Hydrogel for Drug Release of Calcitonin
title_full_unstemmed Thermo-Sensitive mPEG-PA-PLL Hydrogel for Drug Release of Calcitonin
title_short Thermo-Sensitive mPEG-PA-PLL Hydrogel for Drug Release of Calcitonin
title_sort thermo-sensitive mpeg-pa-pll hydrogel for drug release of calcitonin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141101/
https://www.ncbi.nlm.nih.gov/pubmed/35621580
http://dx.doi.org/10.3390/gels8050282
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