Curcumin-Loaded Liposome Preparation in Ultrasound Environment under Pressurized Carbon Dioxide

Curcumin-loaded liposomes were prepared using a supercritical carbon dioxide (SCCO(2))–ultrasound environment system. The experiments were performed at temperatures of 40–70 °C and pressures of 10–25 MPa in a batch system with ultrasonication for 60 min. Transmission electron microscopy (TEM) images...

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Autores principales: Wahyudiono, He, Jiayang, Hu, Xin, Machmudah, Siti, Yasuda, Keiji, Takami, Seiichi, Kanda, Hideki, Goto, Motonobu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141155/
https://www.ncbi.nlm.nih.gov/pubmed/35627039
http://dx.doi.org/10.3390/foods11101469
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author Wahyudiono,
He, Jiayang
Hu, Xin
Machmudah, Siti
Yasuda, Keiji
Takami, Seiichi
Kanda, Hideki
Goto, Motonobu
author_facet Wahyudiono,
He, Jiayang
Hu, Xin
Machmudah, Siti
Yasuda, Keiji
Takami, Seiichi
Kanda, Hideki
Goto, Motonobu
author_sort Wahyudiono,
collection PubMed
description Curcumin-loaded liposomes were prepared using a supercritical carbon dioxide (SCCO(2))–ultrasound environment system. The experiments were performed at temperatures of 40–70 °C and pressures of 10–25 MPa in a batch system with ultrasonication for 60 min. Transmission electron microscopy (TEM) images revealed liposome products with spherical morphologies and diameters of <100 nm. Dynamic light scattering (DLS) analysis indicated that the curcumin-loaded liposome nanosuspension exhibited good stability. Changing the operating conditions influenced the amount of liposome-encapsulated curcumin; as the operating temperature or pressure increased, the diameter of the liposome products and the amount of liposome-encapsulated curcumin increased and decreased, respectively. Herein, we described an innovative and practical organic-solvent-free method for generating liposomes from phospholipids.
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spelling pubmed-91411552022-05-28 Curcumin-Loaded Liposome Preparation in Ultrasound Environment under Pressurized Carbon Dioxide Wahyudiono, He, Jiayang Hu, Xin Machmudah, Siti Yasuda, Keiji Takami, Seiichi Kanda, Hideki Goto, Motonobu Foods Article Curcumin-loaded liposomes were prepared using a supercritical carbon dioxide (SCCO(2))–ultrasound environment system. The experiments were performed at temperatures of 40–70 °C and pressures of 10–25 MPa in a batch system with ultrasonication for 60 min. Transmission electron microscopy (TEM) images revealed liposome products with spherical morphologies and diameters of <100 nm. Dynamic light scattering (DLS) analysis indicated that the curcumin-loaded liposome nanosuspension exhibited good stability. Changing the operating conditions influenced the amount of liposome-encapsulated curcumin; as the operating temperature or pressure increased, the diameter of the liposome products and the amount of liposome-encapsulated curcumin increased and decreased, respectively. Herein, we described an innovative and practical organic-solvent-free method for generating liposomes from phospholipids. MDPI 2022-05-18 /pmc/articles/PMC9141155/ /pubmed/35627039 http://dx.doi.org/10.3390/foods11101469 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wahyudiono,
He, Jiayang
Hu, Xin
Machmudah, Siti
Yasuda, Keiji
Takami, Seiichi
Kanda, Hideki
Goto, Motonobu
Curcumin-Loaded Liposome Preparation in Ultrasound Environment under Pressurized Carbon Dioxide
title Curcumin-Loaded Liposome Preparation in Ultrasound Environment under Pressurized Carbon Dioxide
title_full Curcumin-Loaded Liposome Preparation in Ultrasound Environment under Pressurized Carbon Dioxide
title_fullStr Curcumin-Loaded Liposome Preparation in Ultrasound Environment under Pressurized Carbon Dioxide
title_full_unstemmed Curcumin-Loaded Liposome Preparation in Ultrasound Environment under Pressurized Carbon Dioxide
title_short Curcumin-Loaded Liposome Preparation in Ultrasound Environment under Pressurized Carbon Dioxide
title_sort curcumin-loaded liposome preparation in ultrasound environment under pressurized carbon dioxide
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141155/
https://www.ncbi.nlm.nih.gov/pubmed/35627039
http://dx.doi.org/10.3390/foods11101469
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