Computational Saturation Mutagenesis to Investigate the Effects of Neurexin-1 Mutations on AlphaFold Structure

Neurexin-1 (NRXN1) is a membrane protein essential in synapse formation and cell signaling as a cell-adhesion molecule and cell-surface receptor. NRXN1 and its binding partner neuroligin have been associated with deficits in cognition. Recent genetics research has linked NRXN1 missense mutations to...

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Detalles Bibliográficos
Autores principales: Rhoades, Raina, Henry, Brianna, Prichett, Dominique, Fang, Yayin, Teng, Shaolei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141173/
https://www.ncbi.nlm.nih.gov/pubmed/35627176
http://dx.doi.org/10.3390/genes13050789

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141173/
https://www.ncbi.nlm.nih.gov/pubmed/35627176
http://dx.doi.org/10.3390/genes13050789

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