Immune Checkpoint Blockade via PD-L1 Potentiates More CD28-Based than 4-1BB-Based Anti-Carbonic Anhydrase IX Chimeric Antigen Receptor T Cells

The complete regression of clear cell renal cell carcinoma (ccRCC) obtained pre-clinically with anti-carbonic anhydrase IX (CAIX) G36 chimeric antigen receptor (CAR) T cells in doses equivalent to ≅10(8) CAR T cells/kg renewed the potential of this target to treat ccRCC and other tumors in hypoxia....

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Detalles Bibliográficos
Autores principales: de Campos, Najla Santos Pacheco, de Oliveira Beserra, Adriano, Pereira, Pedro Henrique Barbosa, Chaves, Alexandre Silva, Fonseca, Fernando Luiz Affonso, da Silva Medina, Tiago, dos Santos, Tiago Goss, Wang, Yufei, Marasco, Wayne Anthony, Suarez, Eloah Rabello
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141239/
https://www.ncbi.nlm.nih.gov/pubmed/35628256
http://dx.doi.org/10.3390/ijms23105448

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