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Cerebral Infarction and Evan’s Ratio on MRI Affect the Severity and Prognosis of Tuberculosis Meningitis Patients

Background: Magnetic resonance imaging (MRI) is widely used in the diagnosis of tuberculous meningitis (TBM) and its complications. We aimed to explore the relationship between MRI features and neurological deficits and TBM patients’ prognosis. Methods: patients diagnosed with TBM were subjected to...

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Autores principales: Cao, Xin, Yang, Qingluan, Zhou, Xian, Lv, Kun, Zhou, Zhe, Sun, Feng, Ruan, Qiaoling, Zhang, Jun, Shao, Lingyun, Geng, Daoying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141437/
https://www.ncbi.nlm.nih.gov/pubmed/35626418
http://dx.doi.org/10.3390/diagnostics12051264
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author Cao, Xin
Yang, Qingluan
Zhou, Xian
Lv, Kun
Zhou, Zhe
Sun, Feng
Ruan, Qiaoling
Zhang, Jun
Shao, Lingyun
Geng, Daoying
author_facet Cao, Xin
Yang, Qingluan
Zhou, Xian
Lv, Kun
Zhou, Zhe
Sun, Feng
Ruan, Qiaoling
Zhang, Jun
Shao, Lingyun
Geng, Daoying
author_sort Cao, Xin
collection PubMed
description Background: Magnetic resonance imaging (MRI) is widely used in the diagnosis of tuberculous meningitis (TBM) and its complications. We aimed to explore the relationship between MRI features and neurological deficits and TBM patients’ prognosis. Methods: patients diagnosed with TBM were subjected to a neurological evaluation on admission and divided into groups based on the Medical Research Council (MRC) scale. After several years of follow-up, the patients were further divided into groups according to the Modified Rankin Score (MRS). Their MR images were analyzed for meningeal enhancement, tuberculomas, infarction, hydrocephalus, and abscess, including the location and size of the lesion. Any changes in MRI features during the follow-up were recorded. MRI features between groups were compared, and the relationship between dynamic changes in images and Rankin grading was explored. Results: We found significant differences in acute cerebral infarction (ACI) and old cerebral infarctions (OCI) between the MRC groups, and the ORs of ACI and OCI were 21.818 (95% CI: 2.440–195.075) and 6.788 (95% CI: 1.516–30.392), respectively. There were significant differences in ACI, OCI, and Evan’s ratio between the MRS groups (p < 0.05), and the ORs of ACI, OCI, and hydrocephalus were 6.375 (95% CI: 1.501–27.080), 5.556 (95% CI: 1.332–23.177), and 9.139 (95% CI: 2.052–40.700), respectively. The changes of Evan’s ratio were related to the MRS grading (r = 0.335, p = 0.040). Conclusions: For patients with TBM, the presence of ACI or OCI is associated with neurological deficits, and ACI, OCI, and hydrocephalus can be regarded as poor prognostic predictors. Changes in Evan’s ratio will affect the outcome.
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spelling pubmed-91414372022-05-28 Cerebral Infarction and Evan’s Ratio on MRI Affect the Severity and Prognosis of Tuberculosis Meningitis Patients Cao, Xin Yang, Qingluan Zhou, Xian Lv, Kun Zhou, Zhe Sun, Feng Ruan, Qiaoling Zhang, Jun Shao, Lingyun Geng, Daoying Diagnostics (Basel) Article Background: Magnetic resonance imaging (MRI) is widely used in the diagnosis of tuberculous meningitis (TBM) and its complications. We aimed to explore the relationship between MRI features and neurological deficits and TBM patients’ prognosis. Methods: patients diagnosed with TBM were subjected to a neurological evaluation on admission and divided into groups based on the Medical Research Council (MRC) scale. After several years of follow-up, the patients were further divided into groups according to the Modified Rankin Score (MRS). Their MR images were analyzed for meningeal enhancement, tuberculomas, infarction, hydrocephalus, and abscess, including the location and size of the lesion. Any changes in MRI features during the follow-up were recorded. MRI features between groups were compared, and the relationship between dynamic changes in images and Rankin grading was explored. Results: We found significant differences in acute cerebral infarction (ACI) and old cerebral infarctions (OCI) between the MRC groups, and the ORs of ACI and OCI were 21.818 (95% CI: 2.440–195.075) and 6.788 (95% CI: 1.516–30.392), respectively. There were significant differences in ACI, OCI, and Evan’s ratio between the MRS groups (p < 0.05), and the ORs of ACI, OCI, and hydrocephalus were 6.375 (95% CI: 1.501–27.080), 5.556 (95% CI: 1.332–23.177), and 9.139 (95% CI: 2.052–40.700), respectively. The changes of Evan’s ratio were related to the MRS grading (r = 0.335, p = 0.040). Conclusions: For patients with TBM, the presence of ACI or OCI is associated with neurological deficits, and ACI, OCI, and hydrocephalus can be regarded as poor prognostic predictors. Changes in Evan’s ratio will affect the outcome. MDPI 2022-05-19 /pmc/articles/PMC9141437/ /pubmed/35626418 http://dx.doi.org/10.3390/diagnostics12051264 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cao, Xin
Yang, Qingluan
Zhou, Xian
Lv, Kun
Zhou, Zhe
Sun, Feng
Ruan, Qiaoling
Zhang, Jun
Shao, Lingyun
Geng, Daoying
Cerebral Infarction and Evan’s Ratio on MRI Affect the Severity and Prognosis of Tuberculosis Meningitis Patients
title Cerebral Infarction and Evan’s Ratio on MRI Affect the Severity and Prognosis of Tuberculosis Meningitis Patients
title_full Cerebral Infarction and Evan’s Ratio on MRI Affect the Severity and Prognosis of Tuberculosis Meningitis Patients
title_fullStr Cerebral Infarction and Evan’s Ratio on MRI Affect the Severity and Prognosis of Tuberculosis Meningitis Patients
title_full_unstemmed Cerebral Infarction and Evan’s Ratio on MRI Affect the Severity and Prognosis of Tuberculosis Meningitis Patients
title_short Cerebral Infarction and Evan’s Ratio on MRI Affect the Severity and Prognosis of Tuberculosis Meningitis Patients
title_sort cerebral infarction and evan’s ratio on mri affect the severity and prognosis of tuberculosis meningitis patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141437/
https://www.ncbi.nlm.nih.gov/pubmed/35626418
http://dx.doi.org/10.3390/diagnostics12051264
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