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Anterior Segment-Optical Coherence Tomography Bleb Morphology Comparison in Minimally Invasive Glaucoma Surgery: XEN Gel Stent vs. PreserFlo MicroShunt

Background: The purpose of this study is to compare the morphology of six-month follow-up blebs created by a subconjunctival glaucoma surgical device (XEN45) to those created by a PreserFlo MicroShunt with a sub-Tenon insertion, utilizing AS-OCT. Methods: A retrospective study of 29 eyes who underwe...

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Autores principales: Gambini, Gloria, Carlà, Matteo Mario, Giannuzzi, Federico, Boselli, Francesco, Grieco, Giulia, Caporossi, Tomaso, De Vico, Umberto, Savastano, Alfonso, Baldascino, Antonio, Rizzo, Clara, Kilian, Raphael, Caporossi, Aldo, Rizzo, Stanislao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141468/
https://www.ncbi.nlm.nih.gov/pubmed/35626405
http://dx.doi.org/10.3390/diagnostics12051250
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author Gambini, Gloria
Carlà, Matteo Mario
Giannuzzi, Federico
Boselli, Francesco
Grieco, Giulia
Caporossi, Tomaso
De Vico, Umberto
Savastano, Alfonso
Baldascino, Antonio
Rizzo, Clara
Kilian, Raphael
Caporossi, Aldo
Rizzo, Stanislao
author_facet Gambini, Gloria
Carlà, Matteo Mario
Giannuzzi, Federico
Boselli, Francesco
Grieco, Giulia
Caporossi, Tomaso
De Vico, Umberto
Savastano, Alfonso
Baldascino, Antonio
Rizzo, Clara
Kilian, Raphael
Caporossi, Aldo
Rizzo, Stanislao
author_sort Gambini, Gloria
collection PubMed
description Background: The purpose of this study is to compare the morphology of six-month follow-up blebs created by a subconjunctival glaucoma surgical device (XEN45) to those created by a PreserFlo MicroShunt with a sub-Tenon insertion, utilizing AS-OCT. Methods: A retrospective study of 29 eyes who underwent XEN45 implantation and 29 eyes who underwent PreserFlo MicroShunt implantation. The patients were analyzed at 24 h, 1 week, 1 month, 3 months and 6 months. At each visit, the maturation and morphological alterations of the blebs were observed, as well as connections with the IOP. Results: In both groups, IOP showed significant reduction at all follow ups (p < 0.0001). In XEN group, the most common bleb morphology in the immediate postoperative was the subconjuntival separation type (42%) followed by the uniform type (34%), with a trend inversion at 6 month follow up (51% of uniform type). On the contrary, the most common morphology after PreserFlo was the multiple internal layer (55%), which showed a tendency to reduce over time and was substituted by the microcystic multiform, whose percentage increased over time (17% at day 1 vs. 44% at month 6). Uniform appearance was associated by the posterior episcleral fluid (PEF) lake presence. Both horizontal and vertical diameters significantly increased over time. Conclusion: XEN and PreserFlo implantation resulted in the production of diffuse blebs with different characteristics, which may influence IOP lowering capacity and bleb revisions necessity over time.
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spelling pubmed-91414682022-05-28 Anterior Segment-Optical Coherence Tomography Bleb Morphology Comparison in Minimally Invasive Glaucoma Surgery: XEN Gel Stent vs. PreserFlo MicroShunt Gambini, Gloria Carlà, Matteo Mario Giannuzzi, Federico Boselli, Francesco Grieco, Giulia Caporossi, Tomaso De Vico, Umberto Savastano, Alfonso Baldascino, Antonio Rizzo, Clara Kilian, Raphael Caporossi, Aldo Rizzo, Stanislao Diagnostics (Basel) Article Background: The purpose of this study is to compare the morphology of six-month follow-up blebs created by a subconjunctival glaucoma surgical device (XEN45) to those created by a PreserFlo MicroShunt with a sub-Tenon insertion, utilizing AS-OCT. Methods: A retrospective study of 29 eyes who underwent XEN45 implantation and 29 eyes who underwent PreserFlo MicroShunt implantation. The patients were analyzed at 24 h, 1 week, 1 month, 3 months and 6 months. At each visit, the maturation and morphological alterations of the blebs were observed, as well as connections with the IOP. Results: In both groups, IOP showed significant reduction at all follow ups (p < 0.0001). In XEN group, the most common bleb morphology in the immediate postoperative was the subconjuntival separation type (42%) followed by the uniform type (34%), with a trend inversion at 6 month follow up (51% of uniform type). On the contrary, the most common morphology after PreserFlo was the multiple internal layer (55%), which showed a tendency to reduce over time and was substituted by the microcystic multiform, whose percentage increased over time (17% at day 1 vs. 44% at month 6). Uniform appearance was associated by the posterior episcleral fluid (PEF) lake presence. Both horizontal and vertical diameters significantly increased over time. Conclusion: XEN and PreserFlo implantation resulted in the production of diffuse blebs with different characteristics, which may influence IOP lowering capacity and bleb revisions necessity over time. MDPI 2022-05-17 /pmc/articles/PMC9141468/ /pubmed/35626405 http://dx.doi.org/10.3390/diagnostics12051250 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gambini, Gloria
Carlà, Matteo Mario
Giannuzzi, Federico
Boselli, Francesco
Grieco, Giulia
Caporossi, Tomaso
De Vico, Umberto
Savastano, Alfonso
Baldascino, Antonio
Rizzo, Clara
Kilian, Raphael
Caporossi, Aldo
Rizzo, Stanislao
Anterior Segment-Optical Coherence Tomography Bleb Morphology Comparison in Minimally Invasive Glaucoma Surgery: XEN Gel Stent vs. PreserFlo MicroShunt
title Anterior Segment-Optical Coherence Tomography Bleb Morphology Comparison in Minimally Invasive Glaucoma Surgery: XEN Gel Stent vs. PreserFlo MicroShunt
title_full Anterior Segment-Optical Coherence Tomography Bleb Morphology Comparison in Minimally Invasive Glaucoma Surgery: XEN Gel Stent vs. PreserFlo MicroShunt
title_fullStr Anterior Segment-Optical Coherence Tomography Bleb Morphology Comparison in Minimally Invasive Glaucoma Surgery: XEN Gel Stent vs. PreserFlo MicroShunt
title_full_unstemmed Anterior Segment-Optical Coherence Tomography Bleb Morphology Comparison in Minimally Invasive Glaucoma Surgery: XEN Gel Stent vs. PreserFlo MicroShunt
title_short Anterior Segment-Optical Coherence Tomography Bleb Morphology Comparison in Minimally Invasive Glaucoma Surgery: XEN Gel Stent vs. PreserFlo MicroShunt
title_sort anterior segment-optical coherence tomography bleb morphology comparison in minimally invasive glaucoma surgery: xen gel stent vs. preserflo microshunt
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141468/
https://www.ncbi.nlm.nih.gov/pubmed/35626405
http://dx.doi.org/10.3390/diagnostics12051250
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