Therapeutic Strategies of Biologics in Chronic Rhinosinusitis: Current Options and Future Targets

Chronic rhinosinusitis is a chronic inflammatory disease of the upper airways, for which treatment options include medical or surgical therapy. However, there are limitations to conservative treatment strategies, such as the relapse of nasal polyps. In this review, we discuss the rising role of biom...

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Detalles Bibliográficos
Autores principales: Tai, Junhu, Han, Munsoo, Kim, Tae Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141505/
https://www.ncbi.nlm.nih.gov/pubmed/35628333
http://dx.doi.org/10.3390/ijms23105523
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author Tai, Junhu
Han, Munsoo
Kim, Tae Hoon
author_facet Tai, Junhu
Han, Munsoo
Kim, Tae Hoon
author_sort Tai, Junhu
collection PubMed
description Chronic rhinosinusitis is a chronic inflammatory disease of the upper airways, for which treatment options include medical or surgical therapy. However, there are limitations to conservative treatment strategies, such as the relapse of nasal polyps. In this review, we discuss the rising role of biomolecular mechanisms associated with various biologics that have been approved or are undergoing clinical trials to treat chronic rhinosinusitis. We also highlight the potential molecular therapeutic targets for managing and treating chronic rhinosinusitis.
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spelling pubmed-91415052022-05-28 Therapeutic Strategies of Biologics in Chronic Rhinosinusitis: Current Options and Future Targets Tai, Junhu Han, Munsoo Kim, Tae Hoon Int J Mol Sci Review Chronic rhinosinusitis is a chronic inflammatory disease of the upper airways, for which treatment options include medical or surgical therapy. However, there are limitations to conservative treatment strategies, such as the relapse of nasal polyps. In this review, we discuss the rising role of biomolecular mechanisms associated with various biologics that have been approved or are undergoing clinical trials to treat chronic rhinosinusitis. We also highlight the potential molecular therapeutic targets for managing and treating chronic rhinosinusitis. MDPI 2022-05-15 /pmc/articles/PMC9141505/ /pubmed/35628333 http://dx.doi.org/10.3390/ijms23105523 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tai, Junhu
Han, Munsoo
Kim, Tae Hoon
Therapeutic Strategies of Biologics in Chronic Rhinosinusitis: Current Options and Future Targets
title Therapeutic Strategies of Biologics in Chronic Rhinosinusitis: Current Options and Future Targets
title_full Therapeutic Strategies of Biologics in Chronic Rhinosinusitis: Current Options and Future Targets
title_fullStr Therapeutic Strategies of Biologics in Chronic Rhinosinusitis: Current Options and Future Targets
title_full_unstemmed Therapeutic Strategies of Biologics in Chronic Rhinosinusitis: Current Options and Future Targets
title_short Therapeutic Strategies of Biologics in Chronic Rhinosinusitis: Current Options and Future Targets
title_sort therapeutic strategies of biologics in chronic rhinosinusitis: current options and future targets
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141505/
https://www.ncbi.nlm.nih.gov/pubmed/35628333
http://dx.doi.org/10.3390/ijms23105523
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