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The Prevalence and Predictors of Restless Legs Syndrome in Patients with Liver Cirrhosis
Introduction and aim. Sleep disorders are highly prevalent in patients with liver cirrhosis. The aim of this study was to investigate the prevalence of restless legs syndrome (RLS), as well as its risk factors and possible predictors, in a cohort of patients with liver cirrhosis. Material and method...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141530/ https://www.ncbi.nlm.nih.gov/pubmed/35627959 http://dx.doi.org/10.3390/healthcare10050822 |
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author | Plotogea, Oana-Mihaela Diaconu, Camelia Cristina Gheorghe, Gina Stan-Ilie, Madalina Oprita, Ruxandra Sandru, Vasile Bacalbasa, Nicolae Constantinescu, Gabriel |
author_facet | Plotogea, Oana-Mihaela Diaconu, Camelia Cristina Gheorghe, Gina Stan-Ilie, Madalina Oprita, Ruxandra Sandru, Vasile Bacalbasa, Nicolae Constantinescu, Gabriel |
author_sort | Plotogea, Oana-Mihaela |
collection | PubMed |
description | Introduction and aim. Sleep disorders are highly prevalent in patients with liver cirrhosis. The aim of this study was to investigate the prevalence of restless legs syndrome (RLS), as well as its risk factors and possible predictors, in a cohort of patients with liver cirrhosis. Material and methods. We performed a cross-sectional prospective study over a period of 14 months and enrolled 69 patients with liver cirrhosis, after applying the inclusion and exclusion criteria. The cases of RLS were assessed according to the International Restless Legs Syndrome Study Group (IRLSSG) criteria and severity scale. Results. Out of the total number of patients, 55% fulfilled the criteria for RLS. Age, diabetes, severity of cirrhosis, serum creatinine, glomerular filtration rate (GFR), and mean hemoglobin were associated with the presence of RLS. Moreover, there was a significantly higher prevalence of RLS among patients with decompensated cirrhosis. From all the risk factors introduced into the multivariate analysis, only the GFR could predict the presence of RLS. Conclusions. This research shows that patients with liver cirrhosis have a high risk of RLS. Even though there are multiple risk factors associated with RLS, only the GFR could predict its occurrence in our cohort. |
format | Online Article Text |
id | pubmed-9141530 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91415302022-05-28 The Prevalence and Predictors of Restless Legs Syndrome in Patients with Liver Cirrhosis Plotogea, Oana-Mihaela Diaconu, Camelia Cristina Gheorghe, Gina Stan-Ilie, Madalina Oprita, Ruxandra Sandru, Vasile Bacalbasa, Nicolae Constantinescu, Gabriel Healthcare (Basel) Article Introduction and aim. Sleep disorders are highly prevalent in patients with liver cirrhosis. The aim of this study was to investigate the prevalence of restless legs syndrome (RLS), as well as its risk factors and possible predictors, in a cohort of patients with liver cirrhosis. Material and methods. We performed a cross-sectional prospective study over a period of 14 months and enrolled 69 patients with liver cirrhosis, after applying the inclusion and exclusion criteria. The cases of RLS were assessed according to the International Restless Legs Syndrome Study Group (IRLSSG) criteria and severity scale. Results. Out of the total number of patients, 55% fulfilled the criteria for RLS. Age, diabetes, severity of cirrhosis, serum creatinine, glomerular filtration rate (GFR), and mean hemoglobin were associated with the presence of RLS. Moreover, there was a significantly higher prevalence of RLS among patients with decompensated cirrhosis. From all the risk factors introduced into the multivariate analysis, only the GFR could predict the presence of RLS. Conclusions. This research shows that patients with liver cirrhosis have a high risk of RLS. Even though there are multiple risk factors associated with RLS, only the GFR could predict its occurrence in our cohort. MDPI 2022-04-28 /pmc/articles/PMC9141530/ /pubmed/35627959 http://dx.doi.org/10.3390/healthcare10050822 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Plotogea, Oana-Mihaela Diaconu, Camelia Cristina Gheorghe, Gina Stan-Ilie, Madalina Oprita, Ruxandra Sandru, Vasile Bacalbasa, Nicolae Constantinescu, Gabriel The Prevalence and Predictors of Restless Legs Syndrome in Patients with Liver Cirrhosis |
title | The Prevalence and Predictors of Restless Legs Syndrome in Patients with Liver Cirrhosis |
title_full | The Prevalence and Predictors of Restless Legs Syndrome in Patients with Liver Cirrhosis |
title_fullStr | The Prevalence and Predictors of Restless Legs Syndrome in Patients with Liver Cirrhosis |
title_full_unstemmed | The Prevalence and Predictors of Restless Legs Syndrome in Patients with Liver Cirrhosis |
title_short | The Prevalence and Predictors of Restless Legs Syndrome in Patients with Liver Cirrhosis |
title_sort | prevalence and predictors of restless legs syndrome in patients with liver cirrhosis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141530/ https://www.ncbi.nlm.nih.gov/pubmed/35627959 http://dx.doi.org/10.3390/healthcare10050822 |
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