Nanobody Paratope Ensembles in Solution Characterized by MD Simulations and NMR

Variable domains of camelid antibodies (so-called nanobodies or V(H)H) are the smallest antibody fragments that retain complete functionality and therapeutic potential. Understanding of the nanobody-binding interface has become a pre-requisite for rational antibody design and engineering. The nanobo...

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Detalles Bibliográficos
Autores principales: Fernández-Quintero, Monica L., DeRose, Eugene F., Gabel, Scott A., Mueller, Geoffrey A., Liedl, Klaus R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141556/
https://www.ncbi.nlm.nih.gov/pubmed/35628231
http://dx.doi.org/10.3390/ijms23105419

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141556/
https://www.ncbi.nlm.nih.gov/pubmed/35628231
http://dx.doi.org/10.3390/ijms23105419

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