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Nanobody Paratope Ensembles in Solution Characterized by MD Simulations and NMR
Variable domains of camelid antibodies (so-called nanobodies or V(H)H) are the smallest antibody fragments that retain complete functionality and therapeutic potential. Understanding of the nanobody-binding interface has become a pre-requisite for rational antibody design and engineering. The nanobo...
Autores principales: | Fernández-Quintero, Monica L., DeRose, Eugene F., Gabel, Scott A., Mueller, Geoffrey A., Liedl, Klaus R. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141556/ https://www.ncbi.nlm.nih.gov/pubmed/35628231 http://dx.doi.org/10.3390/ijms23105419 |
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