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Association of SNP rs5069 in APOA1 with Benign Breast Diseases in a Mexican Population
Breast cancer (BCa) is the most common type of cancer affecting women worldwide. Some histological subtypes of benign breast disease (BBD) are considered risk factors for developing BCa. Single nucleotide polymorphisms (SNPs) in the genes encoding apolipoproteins A-I (APOA1) and B (APOB) have been a...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141650/ https://www.ncbi.nlm.nih.gov/pubmed/35627123 http://dx.doi.org/10.3390/genes13050738 |
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author | Domínguez-Díaz, Carolina Morán-Moguel, María Cristina Navarro-Hernandez, Rosa Elena Romo-Vázquez, Rebeca Mendizabal-Ruiz, Adriana Patricia |
author_facet | Domínguez-Díaz, Carolina Morán-Moguel, María Cristina Navarro-Hernandez, Rosa Elena Romo-Vázquez, Rebeca Mendizabal-Ruiz, Adriana Patricia |
author_sort | Domínguez-Díaz, Carolina |
collection | PubMed |
description | Breast cancer (BCa) is the most common type of cancer affecting women worldwide. Some histological subtypes of benign breast disease (BBD) are considered risk factors for developing BCa. Single nucleotide polymorphisms (SNPs) in the genes encoding apolipoproteins A-I (APOA1) and B (APOB) have been associated with BCa in Tunisian, Chinese, and Taiwanese populations. The objective of this pilot study is to evaluate the possible contribution of APOA1 and APOB polymorphisms to BCa and BBD in the Mexican population. We analyzed the association of 4 SNPs in genes encoding apolipoproteins: rs670 and rs5069 in the APOA1 gene, and rs693 and rs1042031 in the APOB gene, by performing PCR-RFLP with DNA extracted from the biopsy tissue of Mexican women with BCa or BBD and whole blood samples obtained from the general population (GP). Our results showed an association between the CT + TT genotypes of the SNP rs5069 and BBD (p = 0.03201). In the A-T haplotype, the frequency of the SNPs rs670 and rs5069 differed significantly between the BBD group and the GP and BCa groups (p = 0.004111; p = 0.01303). In conclusion, the SNP rs5069 is associated with BBD but not with BCa in the Mexican population. |
format | Online Article Text |
id | pubmed-9141650 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91416502022-05-28 Association of SNP rs5069 in APOA1 with Benign Breast Diseases in a Mexican Population Domínguez-Díaz, Carolina Morán-Moguel, María Cristina Navarro-Hernandez, Rosa Elena Romo-Vázquez, Rebeca Mendizabal-Ruiz, Adriana Patricia Genes (Basel) Brief Report Breast cancer (BCa) is the most common type of cancer affecting women worldwide. Some histological subtypes of benign breast disease (BBD) are considered risk factors for developing BCa. Single nucleotide polymorphisms (SNPs) in the genes encoding apolipoproteins A-I (APOA1) and B (APOB) have been associated with BCa in Tunisian, Chinese, and Taiwanese populations. The objective of this pilot study is to evaluate the possible contribution of APOA1 and APOB polymorphisms to BCa and BBD in the Mexican population. We analyzed the association of 4 SNPs in genes encoding apolipoproteins: rs670 and rs5069 in the APOA1 gene, and rs693 and rs1042031 in the APOB gene, by performing PCR-RFLP with DNA extracted from the biopsy tissue of Mexican women with BCa or BBD and whole blood samples obtained from the general population (GP). Our results showed an association between the CT + TT genotypes of the SNP rs5069 and BBD (p = 0.03201). In the A-T haplotype, the frequency of the SNPs rs670 and rs5069 differed significantly between the BBD group and the GP and BCa groups (p = 0.004111; p = 0.01303). In conclusion, the SNP rs5069 is associated with BBD but not with BCa in the Mexican population. MDPI 2022-04-22 /pmc/articles/PMC9141650/ /pubmed/35627123 http://dx.doi.org/10.3390/genes13050738 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Brief Report Domínguez-Díaz, Carolina Morán-Moguel, María Cristina Navarro-Hernandez, Rosa Elena Romo-Vázquez, Rebeca Mendizabal-Ruiz, Adriana Patricia Association of SNP rs5069 in APOA1 with Benign Breast Diseases in a Mexican Population |
title | Association of SNP rs5069 in APOA1 with Benign Breast Diseases in a Mexican Population |
title_full | Association of SNP rs5069 in APOA1 with Benign Breast Diseases in a Mexican Population |
title_fullStr | Association of SNP rs5069 in APOA1 with Benign Breast Diseases in a Mexican Population |
title_full_unstemmed | Association of SNP rs5069 in APOA1 with Benign Breast Diseases in a Mexican Population |
title_short | Association of SNP rs5069 in APOA1 with Benign Breast Diseases in a Mexican Population |
title_sort | association of snp rs5069 in apoa1 with benign breast diseases in a mexican population |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141650/ https://www.ncbi.nlm.nih.gov/pubmed/35627123 http://dx.doi.org/10.3390/genes13050738 |
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