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Association of SNP rs5069 in APOA1 with Benign Breast Diseases in a Mexican Population

Breast cancer (BCa) is the most common type of cancer affecting women worldwide. Some histological subtypes of benign breast disease (BBD) are considered risk factors for developing BCa. Single nucleotide polymorphisms (SNPs) in the genes encoding apolipoproteins A-I (APOA1) and B (APOB) have been a...

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Autores principales: Domínguez-Díaz, Carolina, Morán-Moguel, María Cristina, Navarro-Hernandez, Rosa Elena, Romo-Vázquez, Rebeca, Mendizabal-Ruiz, Adriana Patricia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141650/
https://www.ncbi.nlm.nih.gov/pubmed/35627123
http://dx.doi.org/10.3390/genes13050738
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author Domínguez-Díaz, Carolina
Morán-Moguel, María Cristina
Navarro-Hernandez, Rosa Elena
Romo-Vázquez, Rebeca
Mendizabal-Ruiz, Adriana Patricia
author_facet Domínguez-Díaz, Carolina
Morán-Moguel, María Cristina
Navarro-Hernandez, Rosa Elena
Romo-Vázquez, Rebeca
Mendizabal-Ruiz, Adriana Patricia
author_sort Domínguez-Díaz, Carolina
collection PubMed
description Breast cancer (BCa) is the most common type of cancer affecting women worldwide. Some histological subtypes of benign breast disease (BBD) are considered risk factors for developing BCa. Single nucleotide polymorphisms (SNPs) in the genes encoding apolipoproteins A-I (APOA1) and B (APOB) have been associated with BCa in Tunisian, Chinese, and Taiwanese populations. The objective of this pilot study is to evaluate the possible contribution of APOA1 and APOB polymorphisms to BCa and BBD in the Mexican population. We analyzed the association of 4 SNPs in genes encoding apolipoproteins: rs670 and rs5069 in the APOA1 gene, and rs693 and rs1042031 in the APOB gene, by performing PCR-RFLP with DNA extracted from the biopsy tissue of Mexican women with BCa or BBD and whole blood samples obtained from the general population (GP). Our results showed an association between the CT + TT genotypes of the SNP rs5069 and BBD (p = 0.03201). In the A-T haplotype, the frequency of the SNPs rs670 and rs5069 differed significantly between the BBD group and the GP and BCa groups (p = 0.004111; p = 0.01303). In conclusion, the SNP rs5069 is associated with BBD but not with BCa in the Mexican population.
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spelling pubmed-91416502022-05-28 Association of SNP rs5069 in APOA1 with Benign Breast Diseases in a Mexican Population Domínguez-Díaz, Carolina Morán-Moguel, María Cristina Navarro-Hernandez, Rosa Elena Romo-Vázquez, Rebeca Mendizabal-Ruiz, Adriana Patricia Genes (Basel) Brief Report Breast cancer (BCa) is the most common type of cancer affecting women worldwide. Some histological subtypes of benign breast disease (BBD) are considered risk factors for developing BCa. Single nucleotide polymorphisms (SNPs) in the genes encoding apolipoproteins A-I (APOA1) and B (APOB) have been associated with BCa in Tunisian, Chinese, and Taiwanese populations. The objective of this pilot study is to evaluate the possible contribution of APOA1 and APOB polymorphisms to BCa and BBD in the Mexican population. We analyzed the association of 4 SNPs in genes encoding apolipoproteins: rs670 and rs5069 in the APOA1 gene, and rs693 and rs1042031 in the APOB gene, by performing PCR-RFLP with DNA extracted from the biopsy tissue of Mexican women with BCa or BBD and whole blood samples obtained from the general population (GP). Our results showed an association between the CT + TT genotypes of the SNP rs5069 and BBD (p = 0.03201). In the A-T haplotype, the frequency of the SNPs rs670 and rs5069 differed significantly between the BBD group and the GP and BCa groups (p = 0.004111; p = 0.01303). In conclusion, the SNP rs5069 is associated with BBD but not with BCa in the Mexican population. MDPI 2022-04-22 /pmc/articles/PMC9141650/ /pubmed/35627123 http://dx.doi.org/10.3390/genes13050738 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Domínguez-Díaz, Carolina
Morán-Moguel, María Cristina
Navarro-Hernandez, Rosa Elena
Romo-Vázquez, Rebeca
Mendizabal-Ruiz, Adriana Patricia
Association of SNP rs5069 in APOA1 with Benign Breast Diseases in a Mexican Population
title Association of SNP rs5069 in APOA1 with Benign Breast Diseases in a Mexican Population
title_full Association of SNP rs5069 in APOA1 with Benign Breast Diseases in a Mexican Population
title_fullStr Association of SNP rs5069 in APOA1 with Benign Breast Diseases in a Mexican Population
title_full_unstemmed Association of SNP rs5069 in APOA1 with Benign Breast Diseases in a Mexican Population
title_short Association of SNP rs5069 in APOA1 with Benign Breast Diseases in a Mexican Population
title_sort association of snp rs5069 in apoa1 with benign breast diseases in a mexican population
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141650/
https://www.ncbi.nlm.nih.gov/pubmed/35627123
http://dx.doi.org/10.3390/genes13050738
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