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Bioinformatics Analysis of the Interaction of miRNAs and piRNAs with Human mRNA Genes Having di- and Trinucleotide Repeats
The variability of nucleotide repeats is considered one of the causes of diseases, but their biological function is not understood. In recent years, the interaction of miRNAs and piRNAs with the mRNAs of genes responsible for developing neurodegenerative and oncological diseases and diabetes have be...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141802/ https://www.ncbi.nlm.nih.gov/pubmed/35627185 http://dx.doi.org/10.3390/genes13050800 |
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author | Belkozhayev, Ayaz Niyazova, Raigul Wilson, Cornelia Jainakbayev, Nurlan Pyrkova, Anna Ashirbekov, Yeldar Akimniyazova, Aigul Sharipov, Kamalidin Ivashchenko, Anatoliy |
author_facet | Belkozhayev, Ayaz Niyazova, Raigul Wilson, Cornelia Jainakbayev, Nurlan Pyrkova, Anna Ashirbekov, Yeldar Akimniyazova, Aigul Sharipov, Kamalidin Ivashchenko, Anatoliy |
author_sort | Belkozhayev, Ayaz |
collection | PubMed |
description | The variability of nucleotide repeats is considered one of the causes of diseases, but their biological function is not understood. In recent years, the interaction of miRNAs and piRNAs with the mRNAs of genes responsible for developing neurodegenerative and oncological diseases and diabetes have been actively studied. We explored candidate genes with nucleotide repeats to predict associations with miRNAs and piRNAs. The parameters of miRNAs and piRNA binding sites with mRNAs of human genes having nucleotide repeats were determined using the MirTarget program. This program defines the start of the initiation of miRNA and piRNA binding to mRNAs, the localization of miRNA and piRNA binding sites in the 5′-untranslated region (5′UTR), coding sequence (CDS) and 3′-untranslated region (3′UTR); the free energy of binding; and the schemes of nucleotide interactions of miRNAs and piRNAs with mRNAs. The characteristics of miRNAs and piRNA binding sites with mRNAs of 73 human genes were determined. The 5′UTR, 3′UTR and CDS of the mRNAs of genes are involved in the development of neurodegenerative, oncological and diabetes diseases with GU, AC dinucleotide and CCG, CAG, GCC, CGG, CGC trinucleotide repeats. The associations of miRNAs, piRNAs and candidate target genes could be recommended for developing methods for diagnosing diseases, including neurodegenerative diseases, oncological diseases and diabetes. |
format | Online Article Text |
id | pubmed-9141802 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91418022022-05-28 Bioinformatics Analysis of the Interaction of miRNAs and piRNAs with Human mRNA Genes Having di- and Trinucleotide Repeats Belkozhayev, Ayaz Niyazova, Raigul Wilson, Cornelia Jainakbayev, Nurlan Pyrkova, Anna Ashirbekov, Yeldar Akimniyazova, Aigul Sharipov, Kamalidin Ivashchenko, Anatoliy Genes (Basel) Article The variability of nucleotide repeats is considered one of the causes of diseases, but their biological function is not understood. In recent years, the interaction of miRNAs and piRNAs with the mRNAs of genes responsible for developing neurodegenerative and oncological diseases and diabetes have been actively studied. We explored candidate genes with nucleotide repeats to predict associations with miRNAs and piRNAs. The parameters of miRNAs and piRNA binding sites with mRNAs of human genes having nucleotide repeats were determined using the MirTarget program. This program defines the start of the initiation of miRNA and piRNA binding to mRNAs, the localization of miRNA and piRNA binding sites in the 5′-untranslated region (5′UTR), coding sequence (CDS) and 3′-untranslated region (3′UTR); the free energy of binding; and the schemes of nucleotide interactions of miRNAs and piRNAs with mRNAs. The characteristics of miRNAs and piRNA binding sites with mRNAs of 73 human genes were determined. The 5′UTR, 3′UTR and CDS of the mRNAs of genes are involved in the development of neurodegenerative, oncological and diabetes diseases with GU, AC dinucleotide and CCG, CAG, GCC, CGG, CGC trinucleotide repeats. The associations of miRNAs, piRNAs and candidate target genes could be recommended for developing methods for diagnosing diseases, including neurodegenerative diseases, oncological diseases and diabetes. MDPI 2022-04-29 /pmc/articles/PMC9141802/ /pubmed/35627185 http://dx.doi.org/10.3390/genes13050800 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Belkozhayev, Ayaz Niyazova, Raigul Wilson, Cornelia Jainakbayev, Nurlan Pyrkova, Anna Ashirbekov, Yeldar Akimniyazova, Aigul Sharipov, Kamalidin Ivashchenko, Anatoliy Bioinformatics Analysis of the Interaction of miRNAs and piRNAs with Human mRNA Genes Having di- and Trinucleotide Repeats |
title | Bioinformatics Analysis of the Interaction of miRNAs and piRNAs with Human mRNA Genes Having di- and Trinucleotide Repeats |
title_full | Bioinformatics Analysis of the Interaction of miRNAs and piRNAs with Human mRNA Genes Having di- and Trinucleotide Repeats |
title_fullStr | Bioinformatics Analysis of the Interaction of miRNAs and piRNAs with Human mRNA Genes Having di- and Trinucleotide Repeats |
title_full_unstemmed | Bioinformatics Analysis of the Interaction of miRNAs and piRNAs with Human mRNA Genes Having di- and Trinucleotide Repeats |
title_short | Bioinformatics Analysis of the Interaction of miRNAs and piRNAs with Human mRNA Genes Having di- and Trinucleotide Repeats |
title_sort | bioinformatics analysis of the interaction of mirnas and pirnas with human mrna genes having di- and trinucleotide repeats |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141802/ https://www.ncbi.nlm.nih.gov/pubmed/35627185 http://dx.doi.org/10.3390/genes13050800 |
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