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Bioinformatics Analysis of the Interaction of miRNAs and piRNAs with Human mRNA Genes Having di- and Trinucleotide Repeats

The variability of nucleotide repeats is considered one of the causes of diseases, but their biological function is not understood. In recent years, the interaction of miRNAs and piRNAs with the mRNAs of genes responsible for developing neurodegenerative and oncological diseases and diabetes have be...

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Autores principales: Belkozhayev, Ayaz, Niyazova, Raigul, Wilson, Cornelia, Jainakbayev, Nurlan, Pyrkova, Anna, Ashirbekov, Yeldar, Akimniyazova, Aigul, Sharipov, Kamalidin, Ivashchenko, Anatoliy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141802/
https://www.ncbi.nlm.nih.gov/pubmed/35627185
http://dx.doi.org/10.3390/genes13050800
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author Belkozhayev, Ayaz
Niyazova, Raigul
Wilson, Cornelia
Jainakbayev, Nurlan
Pyrkova, Anna
Ashirbekov, Yeldar
Akimniyazova, Aigul
Sharipov, Kamalidin
Ivashchenko, Anatoliy
author_facet Belkozhayev, Ayaz
Niyazova, Raigul
Wilson, Cornelia
Jainakbayev, Nurlan
Pyrkova, Anna
Ashirbekov, Yeldar
Akimniyazova, Aigul
Sharipov, Kamalidin
Ivashchenko, Anatoliy
author_sort Belkozhayev, Ayaz
collection PubMed
description The variability of nucleotide repeats is considered one of the causes of diseases, but their biological function is not understood. In recent years, the interaction of miRNAs and piRNAs with the mRNAs of genes responsible for developing neurodegenerative and oncological diseases and diabetes have been actively studied. We explored candidate genes with nucleotide repeats to predict associations with miRNAs and piRNAs. The parameters of miRNAs and piRNA binding sites with mRNAs of human genes having nucleotide repeats were determined using the MirTarget program. This program defines the start of the initiation of miRNA and piRNA binding to mRNAs, the localization of miRNA and piRNA binding sites in the 5′-untranslated region (5′UTR), coding sequence (CDS) and 3′-untranslated region (3′UTR); the free energy of binding; and the schemes of nucleotide interactions of miRNAs and piRNAs with mRNAs. The characteristics of miRNAs and piRNA binding sites with mRNAs of 73 human genes were determined. The 5′UTR, 3′UTR and CDS of the mRNAs of genes are involved in the development of neurodegenerative, oncological and diabetes diseases with GU, AC dinucleotide and CCG, CAG, GCC, CGG, CGC trinucleotide repeats. The associations of miRNAs, piRNAs and candidate target genes could be recommended for developing methods for diagnosing diseases, including neurodegenerative diseases, oncological diseases and diabetes.
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spelling pubmed-91418022022-05-28 Bioinformatics Analysis of the Interaction of miRNAs and piRNAs with Human mRNA Genes Having di- and Trinucleotide Repeats Belkozhayev, Ayaz Niyazova, Raigul Wilson, Cornelia Jainakbayev, Nurlan Pyrkova, Anna Ashirbekov, Yeldar Akimniyazova, Aigul Sharipov, Kamalidin Ivashchenko, Anatoliy Genes (Basel) Article The variability of nucleotide repeats is considered one of the causes of diseases, but their biological function is not understood. In recent years, the interaction of miRNAs and piRNAs with the mRNAs of genes responsible for developing neurodegenerative and oncological diseases and diabetes have been actively studied. We explored candidate genes with nucleotide repeats to predict associations with miRNAs and piRNAs. The parameters of miRNAs and piRNA binding sites with mRNAs of human genes having nucleotide repeats were determined using the MirTarget program. This program defines the start of the initiation of miRNA and piRNA binding to mRNAs, the localization of miRNA and piRNA binding sites in the 5′-untranslated region (5′UTR), coding sequence (CDS) and 3′-untranslated region (3′UTR); the free energy of binding; and the schemes of nucleotide interactions of miRNAs and piRNAs with mRNAs. The characteristics of miRNAs and piRNA binding sites with mRNAs of 73 human genes were determined. The 5′UTR, 3′UTR and CDS of the mRNAs of genes are involved in the development of neurodegenerative, oncological and diabetes diseases with GU, AC dinucleotide and CCG, CAG, GCC, CGG, CGC trinucleotide repeats. The associations of miRNAs, piRNAs and candidate target genes could be recommended for developing methods for diagnosing diseases, including neurodegenerative diseases, oncological diseases and diabetes. MDPI 2022-04-29 /pmc/articles/PMC9141802/ /pubmed/35627185 http://dx.doi.org/10.3390/genes13050800 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Belkozhayev, Ayaz
Niyazova, Raigul
Wilson, Cornelia
Jainakbayev, Nurlan
Pyrkova, Anna
Ashirbekov, Yeldar
Akimniyazova, Aigul
Sharipov, Kamalidin
Ivashchenko, Anatoliy
Bioinformatics Analysis of the Interaction of miRNAs and piRNAs with Human mRNA Genes Having di- and Trinucleotide Repeats
title Bioinformatics Analysis of the Interaction of miRNAs and piRNAs with Human mRNA Genes Having di- and Trinucleotide Repeats
title_full Bioinformatics Analysis of the Interaction of miRNAs and piRNAs with Human mRNA Genes Having di- and Trinucleotide Repeats
title_fullStr Bioinformatics Analysis of the Interaction of miRNAs and piRNAs with Human mRNA Genes Having di- and Trinucleotide Repeats
title_full_unstemmed Bioinformatics Analysis of the Interaction of miRNAs and piRNAs with Human mRNA Genes Having di- and Trinucleotide Repeats
title_short Bioinformatics Analysis of the Interaction of miRNAs and piRNAs with Human mRNA Genes Having di- and Trinucleotide Repeats
title_sort bioinformatics analysis of the interaction of mirnas and pirnas with human mrna genes having di- and trinucleotide repeats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141802/
https://www.ncbi.nlm.nih.gov/pubmed/35627185
http://dx.doi.org/10.3390/genes13050800
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