Cargando…

Gene Polymorphisms of Hormonal Regulators of Metabolism in Patients with Schizophrenia with Metabolic Syndrome

Background: Metabolic syndrome (MetS) is a common complication of long-term treatment of persons with schizophrenia taking (atypical) antipsychotics. In this study, we investigated the existence of an association with polymorphisms of genes for four hormones that regulate energy metabolism. Methods:...

Descripción completa

Detalles Bibliográficos
Autores principales: Boiko, Anastasiia S., Pozhidaev, Ivan V., Paderina, Diana Z., Mednova, Irina A., Goncharova, Anastasya A., Fedorenko, Olga Yu., Kornetova, Elena G., Semke, Arkadiy V., Bokhan, Nikolay A., Loonen, Anton J. M., Ivanova, Svetlana A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141866/
https://www.ncbi.nlm.nih.gov/pubmed/35627229
http://dx.doi.org/10.3390/genes13050844
_version_ 1784715447920230400
author Boiko, Anastasiia S.
Pozhidaev, Ivan V.
Paderina, Diana Z.
Mednova, Irina A.
Goncharova, Anastasya A.
Fedorenko, Olga Yu.
Kornetova, Elena G.
Semke, Arkadiy V.
Bokhan, Nikolay A.
Loonen, Anton J. M.
Ivanova, Svetlana A.
author_facet Boiko, Anastasiia S.
Pozhidaev, Ivan V.
Paderina, Diana Z.
Mednova, Irina A.
Goncharova, Anastasya A.
Fedorenko, Olga Yu.
Kornetova, Elena G.
Semke, Arkadiy V.
Bokhan, Nikolay A.
Loonen, Anton J. M.
Ivanova, Svetlana A.
author_sort Boiko, Anastasiia S.
collection PubMed
description Background: Metabolic syndrome (MetS) is a common complication of long-term treatment of persons with schizophrenia taking (atypical) antipsychotics. In this study, we investigated the existence of an association with polymorphisms of genes for four hormones that regulate energy metabolism. Methods: We recruited 517 clinically admitted white patients (269M/248F) with a verified diagnosis of schizophrenia (ICD-10) and with a stable physical condition. Participants were classified for having or not having MetS and genotyped for 20 single-nucleotide polymorphisms (SNPs) in the genes encoding insulin-induced gene 2 (INSIG2), ghrelin (GHRL), leptin (LEP), and leptin receptor (LEPR). Results: The 139 patients (26.9%) with MetS were significantly more likely to be women, older, and ill longer, and had a larger body mass index (BMI). Four polymorphisms (rs10490624, rs17587100, rs9308762, and rs10490816) did not meet the Hardy–Weinberg equilibrium (HWE) criterion and were excluded. Only genotypes and alleles of the rs3828942 of LEP gene (chi2 = 7.665, p = 0.022; chi2 = 5.136, p = 0.023) and the genotypes of the rs17047718 of INSIG2 gene (chi2 = 7.7, p = 0.021) had a significant association with MetS. Conclusions: The results of our study suggest that the LEP and INSIG2 genes play a certain causal role in the development of MetS in patients with schizophrenia.
format Online
Article
Text
id pubmed-9141866
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-91418662022-05-28 Gene Polymorphisms of Hormonal Regulators of Metabolism in Patients with Schizophrenia with Metabolic Syndrome Boiko, Anastasiia S. Pozhidaev, Ivan V. Paderina, Diana Z. Mednova, Irina A. Goncharova, Anastasya A. Fedorenko, Olga Yu. Kornetova, Elena G. Semke, Arkadiy V. Bokhan, Nikolay A. Loonen, Anton J. M. Ivanova, Svetlana A. Genes (Basel) Article Background: Metabolic syndrome (MetS) is a common complication of long-term treatment of persons with schizophrenia taking (atypical) antipsychotics. In this study, we investigated the existence of an association with polymorphisms of genes for four hormones that regulate energy metabolism. Methods: We recruited 517 clinically admitted white patients (269M/248F) with a verified diagnosis of schizophrenia (ICD-10) and with a stable physical condition. Participants were classified for having or not having MetS and genotyped for 20 single-nucleotide polymorphisms (SNPs) in the genes encoding insulin-induced gene 2 (INSIG2), ghrelin (GHRL), leptin (LEP), and leptin receptor (LEPR). Results: The 139 patients (26.9%) with MetS were significantly more likely to be women, older, and ill longer, and had a larger body mass index (BMI). Four polymorphisms (rs10490624, rs17587100, rs9308762, and rs10490816) did not meet the Hardy–Weinberg equilibrium (HWE) criterion and were excluded. Only genotypes and alleles of the rs3828942 of LEP gene (chi2 = 7.665, p = 0.022; chi2 = 5.136, p = 0.023) and the genotypes of the rs17047718 of INSIG2 gene (chi2 = 7.7, p = 0.021) had a significant association with MetS. Conclusions: The results of our study suggest that the LEP and INSIG2 genes play a certain causal role in the development of MetS in patients with schizophrenia. MDPI 2022-05-08 /pmc/articles/PMC9141866/ /pubmed/35627229 http://dx.doi.org/10.3390/genes13050844 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Boiko, Anastasiia S.
Pozhidaev, Ivan V.
Paderina, Diana Z.
Mednova, Irina A.
Goncharova, Anastasya A.
Fedorenko, Olga Yu.
Kornetova, Elena G.
Semke, Arkadiy V.
Bokhan, Nikolay A.
Loonen, Anton J. M.
Ivanova, Svetlana A.
Gene Polymorphisms of Hormonal Regulators of Metabolism in Patients with Schizophrenia with Metabolic Syndrome
title Gene Polymorphisms of Hormonal Regulators of Metabolism in Patients with Schizophrenia with Metabolic Syndrome
title_full Gene Polymorphisms of Hormonal Regulators of Metabolism in Patients with Schizophrenia with Metabolic Syndrome
title_fullStr Gene Polymorphisms of Hormonal Regulators of Metabolism in Patients with Schizophrenia with Metabolic Syndrome
title_full_unstemmed Gene Polymorphisms of Hormonal Regulators of Metabolism in Patients with Schizophrenia with Metabolic Syndrome
title_short Gene Polymorphisms of Hormonal Regulators of Metabolism in Patients with Schizophrenia with Metabolic Syndrome
title_sort gene polymorphisms of hormonal regulators of metabolism in patients with schizophrenia with metabolic syndrome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141866/
https://www.ncbi.nlm.nih.gov/pubmed/35627229
http://dx.doi.org/10.3390/genes13050844
work_keys_str_mv AT boikoanastasiias genepolymorphismsofhormonalregulatorsofmetabolisminpatientswithschizophreniawithmetabolicsyndrome
AT pozhidaevivanv genepolymorphismsofhormonalregulatorsofmetabolisminpatientswithschizophreniawithmetabolicsyndrome
AT paderinadianaz genepolymorphismsofhormonalregulatorsofmetabolisminpatientswithschizophreniawithmetabolicsyndrome
AT mednovairinaa genepolymorphismsofhormonalregulatorsofmetabolisminpatientswithschizophreniawithmetabolicsyndrome
AT goncharovaanastasyaa genepolymorphismsofhormonalregulatorsofmetabolisminpatientswithschizophreniawithmetabolicsyndrome
AT fedorenkoolgayu genepolymorphismsofhormonalregulatorsofmetabolisminpatientswithschizophreniawithmetabolicsyndrome
AT kornetovaelenag genepolymorphismsofhormonalregulatorsofmetabolisminpatientswithschizophreniawithmetabolicsyndrome
AT semkearkadiyv genepolymorphismsofhormonalregulatorsofmetabolisminpatientswithschizophreniawithmetabolicsyndrome
AT bokhannikolaya genepolymorphismsofhormonalregulatorsofmetabolisminpatientswithschizophreniawithmetabolicsyndrome
AT loonenantonjm genepolymorphismsofhormonalregulatorsofmetabolisminpatientswithschizophreniawithmetabolicsyndrome
AT ivanovasvetlanaa genepolymorphismsofhormonalregulatorsofmetabolisminpatientswithschizophreniawithmetabolicsyndrome