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Gene Polymorphisms of Hormonal Regulators of Metabolism in Patients with Schizophrenia with Metabolic Syndrome
Background: Metabolic syndrome (MetS) is a common complication of long-term treatment of persons with schizophrenia taking (atypical) antipsychotics. In this study, we investigated the existence of an association with polymorphisms of genes for four hormones that regulate energy metabolism. Methods:...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141866/ https://www.ncbi.nlm.nih.gov/pubmed/35627229 http://dx.doi.org/10.3390/genes13050844 |
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author | Boiko, Anastasiia S. Pozhidaev, Ivan V. Paderina, Diana Z. Mednova, Irina A. Goncharova, Anastasya A. Fedorenko, Olga Yu. Kornetova, Elena G. Semke, Arkadiy V. Bokhan, Nikolay A. Loonen, Anton J. M. Ivanova, Svetlana A. |
author_facet | Boiko, Anastasiia S. Pozhidaev, Ivan V. Paderina, Diana Z. Mednova, Irina A. Goncharova, Anastasya A. Fedorenko, Olga Yu. Kornetova, Elena G. Semke, Arkadiy V. Bokhan, Nikolay A. Loonen, Anton J. M. Ivanova, Svetlana A. |
author_sort | Boiko, Anastasiia S. |
collection | PubMed |
description | Background: Metabolic syndrome (MetS) is a common complication of long-term treatment of persons with schizophrenia taking (atypical) antipsychotics. In this study, we investigated the existence of an association with polymorphisms of genes for four hormones that regulate energy metabolism. Methods: We recruited 517 clinically admitted white patients (269M/248F) with a verified diagnosis of schizophrenia (ICD-10) and with a stable physical condition. Participants were classified for having or not having MetS and genotyped for 20 single-nucleotide polymorphisms (SNPs) in the genes encoding insulin-induced gene 2 (INSIG2), ghrelin (GHRL), leptin (LEP), and leptin receptor (LEPR). Results: The 139 patients (26.9%) with MetS were significantly more likely to be women, older, and ill longer, and had a larger body mass index (BMI). Four polymorphisms (rs10490624, rs17587100, rs9308762, and rs10490816) did not meet the Hardy–Weinberg equilibrium (HWE) criterion and were excluded. Only genotypes and alleles of the rs3828942 of LEP gene (chi2 = 7.665, p = 0.022; chi2 = 5.136, p = 0.023) and the genotypes of the rs17047718 of INSIG2 gene (chi2 = 7.7, p = 0.021) had a significant association with MetS. Conclusions: The results of our study suggest that the LEP and INSIG2 genes play a certain causal role in the development of MetS in patients with schizophrenia. |
format | Online Article Text |
id | pubmed-9141866 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91418662022-05-28 Gene Polymorphisms of Hormonal Regulators of Metabolism in Patients with Schizophrenia with Metabolic Syndrome Boiko, Anastasiia S. Pozhidaev, Ivan V. Paderina, Diana Z. Mednova, Irina A. Goncharova, Anastasya A. Fedorenko, Olga Yu. Kornetova, Elena G. Semke, Arkadiy V. Bokhan, Nikolay A. Loonen, Anton J. M. Ivanova, Svetlana A. Genes (Basel) Article Background: Metabolic syndrome (MetS) is a common complication of long-term treatment of persons with schizophrenia taking (atypical) antipsychotics. In this study, we investigated the existence of an association with polymorphisms of genes for four hormones that regulate energy metabolism. Methods: We recruited 517 clinically admitted white patients (269M/248F) with a verified diagnosis of schizophrenia (ICD-10) and with a stable physical condition. Participants were classified for having or not having MetS and genotyped for 20 single-nucleotide polymorphisms (SNPs) in the genes encoding insulin-induced gene 2 (INSIG2), ghrelin (GHRL), leptin (LEP), and leptin receptor (LEPR). Results: The 139 patients (26.9%) with MetS were significantly more likely to be women, older, and ill longer, and had a larger body mass index (BMI). Four polymorphisms (rs10490624, rs17587100, rs9308762, and rs10490816) did not meet the Hardy–Weinberg equilibrium (HWE) criterion and were excluded. Only genotypes and alleles of the rs3828942 of LEP gene (chi2 = 7.665, p = 0.022; chi2 = 5.136, p = 0.023) and the genotypes of the rs17047718 of INSIG2 gene (chi2 = 7.7, p = 0.021) had a significant association with MetS. Conclusions: The results of our study suggest that the LEP and INSIG2 genes play a certain causal role in the development of MetS in patients with schizophrenia. MDPI 2022-05-08 /pmc/articles/PMC9141866/ /pubmed/35627229 http://dx.doi.org/10.3390/genes13050844 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Boiko, Anastasiia S. Pozhidaev, Ivan V. Paderina, Diana Z. Mednova, Irina A. Goncharova, Anastasya A. Fedorenko, Olga Yu. Kornetova, Elena G. Semke, Arkadiy V. Bokhan, Nikolay A. Loonen, Anton J. M. Ivanova, Svetlana A. Gene Polymorphisms of Hormonal Regulators of Metabolism in Patients with Schizophrenia with Metabolic Syndrome |
title | Gene Polymorphisms of Hormonal Regulators of Metabolism in Patients with Schizophrenia with Metabolic Syndrome |
title_full | Gene Polymorphisms of Hormonal Regulators of Metabolism in Patients with Schizophrenia with Metabolic Syndrome |
title_fullStr | Gene Polymorphisms of Hormonal Regulators of Metabolism in Patients with Schizophrenia with Metabolic Syndrome |
title_full_unstemmed | Gene Polymorphisms of Hormonal Regulators of Metabolism in Patients with Schizophrenia with Metabolic Syndrome |
title_short | Gene Polymorphisms of Hormonal Regulators of Metabolism in Patients with Schizophrenia with Metabolic Syndrome |
title_sort | gene polymorphisms of hormonal regulators of metabolism in patients with schizophrenia with metabolic syndrome |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141866/ https://www.ncbi.nlm.nih.gov/pubmed/35627229 http://dx.doi.org/10.3390/genes13050844 |
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