Cargando…
Evaluating the Effect of Kaftrio on Perspectives of Health and Wellbeing in Individuals with Cystic Fibrosis
Background: Modulator therapy represents a significant step forward in CF care and is expected to have a significant impact on the health and mortality of many individuals with CF. Studies have predominantly explored the physiological effects of modulator therapy on clinical outcomes, with little co...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141876/ https://www.ncbi.nlm.nih.gov/pubmed/35627651 http://dx.doi.org/10.3390/ijerph19106114 |
_version_ | 1784715450339295232 |
---|---|
author | Aspinall, Sean A. Mackintosh, Kelly A. Hill, Denise M. Cope, Bethany McNarry, Melitta A. |
author_facet | Aspinall, Sean A. Mackintosh, Kelly A. Hill, Denise M. Cope, Bethany McNarry, Melitta A. |
author_sort | Aspinall, Sean A. |
collection | PubMed |
description | Background: Modulator therapy represents a significant step forward in CF care and is expected to have a significant impact on the health and mortality of many individuals with CF. Studies have predominantly explored the physiological effects of modulator therapy on clinical outcomes, with little consideration of the individual lived experience of modulator therapy among adults with Cystic Fibrosis. Methods: To explore this, semi-structured interviews were conducted with 12 individuals currently taking Kaftrio, which were subsequently thematically analysed. Results: Three overarching themes were identified: (i) positive perception of Kaftrio, (ii) negative perception of Kaftrio, and (iii) the relationships with the clinical team. The experience of modulator therapy should be recognised as being unique to the individual, with perceptions of illness, self-identity, and outcomes strongly dictating the lived experience. Conclusions: There is a consensus that, while for many, the quality of life is evidently increased through the use of Kaftrio, this is not without its own challenges. This highlights the need for both individuals with CF and their clinical teams to learn to navigate this new disease landscape. |
format | Online Article Text |
id | pubmed-9141876 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91418762022-05-28 Evaluating the Effect of Kaftrio on Perspectives of Health and Wellbeing in Individuals with Cystic Fibrosis Aspinall, Sean A. Mackintosh, Kelly A. Hill, Denise M. Cope, Bethany McNarry, Melitta A. Int J Environ Res Public Health Article Background: Modulator therapy represents a significant step forward in CF care and is expected to have a significant impact on the health and mortality of many individuals with CF. Studies have predominantly explored the physiological effects of modulator therapy on clinical outcomes, with little consideration of the individual lived experience of modulator therapy among adults with Cystic Fibrosis. Methods: To explore this, semi-structured interviews were conducted with 12 individuals currently taking Kaftrio, which were subsequently thematically analysed. Results: Three overarching themes were identified: (i) positive perception of Kaftrio, (ii) negative perception of Kaftrio, and (iii) the relationships with the clinical team. The experience of modulator therapy should be recognised as being unique to the individual, with perceptions of illness, self-identity, and outcomes strongly dictating the lived experience. Conclusions: There is a consensus that, while for many, the quality of life is evidently increased through the use of Kaftrio, this is not without its own challenges. This highlights the need for both individuals with CF and their clinical teams to learn to navigate this new disease landscape. MDPI 2022-05-17 /pmc/articles/PMC9141876/ /pubmed/35627651 http://dx.doi.org/10.3390/ijerph19106114 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Aspinall, Sean A. Mackintosh, Kelly A. Hill, Denise M. Cope, Bethany McNarry, Melitta A. Evaluating the Effect of Kaftrio on Perspectives of Health and Wellbeing in Individuals with Cystic Fibrosis |
title | Evaluating the Effect of Kaftrio on Perspectives of Health and Wellbeing in Individuals with Cystic Fibrosis |
title_full | Evaluating the Effect of Kaftrio on Perspectives of Health and Wellbeing in Individuals with Cystic Fibrosis |
title_fullStr | Evaluating the Effect of Kaftrio on Perspectives of Health and Wellbeing in Individuals with Cystic Fibrosis |
title_full_unstemmed | Evaluating the Effect of Kaftrio on Perspectives of Health and Wellbeing in Individuals with Cystic Fibrosis |
title_short | Evaluating the Effect of Kaftrio on Perspectives of Health and Wellbeing in Individuals with Cystic Fibrosis |
title_sort | evaluating the effect of kaftrio on perspectives of health and wellbeing in individuals with cystic fibrosis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141876/ https://www.ncbi.nlm.nih.gov/pubmed/35627651 http://dx.doi.org/10.3390/ijerph19106114 |
work_keys_str_mv | AT aspinallseana evaluatingtheeffectofkaftrioonperspectivesofhealthandwellbeinginindividualswithcysticfibrosis AT mackintoshkellya evaluatingtheeffectofkaftrioonperspectivesofhealthandwellbeinginindividualswithcysticfibrosis AT hilldenisem evaluatingtheeffectofkaftrioonperspectivesofhealthandwellbeinginindividualswithcysticfibrosis AT copebethany evaluatingtheeffectofkaftrioonperspectivesofhealthandwellbeinginindividualswithcysticfibrosis AT mcnarrymelittaa evaluatingtheeffectofkaftrioonperspectivesofhealthandwellbeinginindividualswithcysticfibrosis |