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Immunomodulation of Oxidative Stress during Organ Donation Process: Preliminary Results
The objective was to quantify oxidative stress resulting from ischemia during the donation process, using malondialdehyde (MDA) measurement, and its modulation by the administration of melatonin. We designed a triple-blind clinical trial with donors randomized to melatonin or placebo. We collected d...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141959/ https://www.ncbi.nlm.nih.gov/pubmed/35627899 http://dx.doi.org/10.3390/healthcare10050762 |
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author | Palomo-López, Nora Rodríguez-Rodríguez, Ana Martín-Villén, Luis Mendoza-Prieto, María Ruiz de Azúa-López, Zaida Sempere-Bordes, Lluis Boyero-Corral, Laura Daga-Ruiz, Domingo Gordillo-Brenes, Antonio Pacheco-Sánchez, María Perez-Villares, José Miguel Vilches-Arenas, Ángel Egea-Guerrero, Juan José |
author_facet | Palomo-López, Nora Rodríguez-Rodríguez, Ana Martín-Villén, Luis Mendoza-Prieto, María Ruiz de Azúa-López, Zaida Sempere-Bordes, Lluis Boyero-Corral, Laura Daga-Ruiz, Domingo Gordillo-Brenes, Antonio Pacheco-Sánchez, María Perez-Villares, José Miguel Vilches-Arenas, Ángel Egea-Guerrero, Juan José |
author_sort | Palomo-López, Nora |
collection | PubMed |
description | The objective was to quantify oxidative stress resulting from ischemia during the donation process, using malondialdehyde (MDA) measurement, and its modulation by the administration of melatonin. We designed a triple-blind clinical trial with donors randomized to melatonin or placebo. We collected donors by donation after brain death (DBD) and controlled donation after circulatory death (DCD), the latter maintained by normothermic regional perfusion (NRP). Melatonin or placebo was administered prior to donation or following limitation of therapeutic effort (LTE). Demographic variables and medical history were collected. We also collected serial measurements of MDA, at 60 and 90 min after melatonin or placebo administration. A total of 53 donors were included (32 from DBD and 21 from DCD). In the DBD group, 17 donors received melatonin, and 15 placebo. Eight DCD donors were randomized to melatonin and 13 to placebo. Medical history and cause for LTE were similar between groups. Although MDA values did not differ in the DBD group, statistical differences were observed in DCD donors during the 0–60 min interval: −4.296 (−6.752; −2.336) in the melatonin group and −1.612 (−2.886; −0.7445) in controls. Given the antioxidant effect of melatonin, its use could reduce the production of oxidative stress in controlled DCD. |
format | Online Article Text |
id | pubmed-9141959 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91419592022-05-28 Immunomodulation of Oxidative Stress during Organ Donation Process: Preliminary Results Palomo-López, Nora Rodríguez-Rodríguez, Ana Martín-Villén, Luis Mendoza-Prieto, María Ruiz de Azúa-López, Zaida Sempere-Bordes, Lluis Boyero-Corral, Laura Daga-Ruiz, Domingo Gordillo-Brenes, Antonio Pacheco-Sánchez, María Perez-Villares, José Miguel Vilches-Arenas, Ángel Egea-Guerrero, Juan José Healthcare (Basel) Article The objective was to quantify oxidative stress resulting from ischemia during the donation process, using malondialdehyde (MDA) measurement, and its modulation by the administration of melatonin. We designed a triple-blind clinical trial with donors randomized to melatonin or placebo. We collected donors by donation after brain death (DBD) and controlled donation after circulatory death (DCD), the latter maintained by normothermic regional perfusion (NRP). Melatonin or placebo was administered prior to donation or following limitation of therapeutic effort (LTE). Demographic variables and medical history were collected. We also collected serial measurements of MDA, at 60 and 90 min after melatonin or placebo administration. A total of 53 donors were included (32 from DBD and 21 from DCD). In the DBD group, 17 donors received melatonin, and 15 placebo. Eight DCD donors were randomized to melatonin and 13 to placebo. Medical history and cause for LTE were similar between groups. Although MDA values did not differ in the DBD group, statistical differences were observed in DCD donors during the 0–60 min interval: −4.296 (−6.752; −2.336) in the melatonin group and −1.612 (−2.886; −0.7445) in controls. Given the antioxidant effect of melatonin, its use could reduce the production of oxidative stress in controlled DCD. MDPI 2022-04-20 /pmc/articles/PMC9141959/ /pubmed/35627899 http://dx.doi.org/10.3390/healthcare10050762 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Palomo-López, Nora Rodríguez-Rodríguez, Ana Martín-Villén, Luis Mendoza-Prieto, María Ruiz de Azúa-López, Zaida Sempere-Bordes, Lluis Boyero-Corral, Laura Daga-Ruiz, Domingo Gordillo-Brenes, Antonio Pacheco-Sánchez, María Perez-Villares, José Miguel Vilches-Arenas, Ángel Egea-Guerrero, Juan José Immunomodulation of Oxidative Stress during Organ Donation Process: Preliminary Results |
title | Immunomodulation of Oxidative Stress during Organ Donation Process: Preliminary Results |
title_full | Immunomodulation of Oxidative Stress during Organ Donation Process: Preliminary Results |
title_fullStr | Immunomodulation of Oxidative Stress during Organ Donation Process: Preliminary Results |
title_full_unstemmed | Immunomodulation of Oxidative Stress during Organ Donation Process: Preliminary Results |
title_short | Immunomodulation of Oxidative Stress during Organ Donation Process: Preliminary Results |
title_sort | immunomodulation of oxidative stress during organ donation process: preliminary results |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141959/ https://www.ncbi.nlm.nih.gov/pubmed/35627899 http://dx.doi.org/10.3390/healthcare10050762 |
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